Yong Q Li

US Patent:

59622458, Oct 5, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/475055

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

C12Q 134
C12Q 100
G01N 33566

US Classification:

435 18

Abstract:

The present invention is directed to methods for detecting the presence of advanced glycosylation endproducts using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and lactoferrin, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to diagnostic methods for diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain. The invention further relates to compositions and devices for partitioning AGEs away from a sample.

US Patent:

58558829, Jan 5, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/485948

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

A61K 3847
A61K 3816

US Classification:

424 9461

Abstract:

The present invention is directed to methods for inhibiting the cross-linking of advanced glycosylation endproducts in a subject suspected of having elevated levels of AGEs by using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and particular fragments thereof, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to therapeutic methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain to remove AGEs from biological material. The invention further relates to compositions for inhibiting the cross-linking of AGEs in a subject in need of such therapy.

US Patent:

58612386, Jan 19, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/487058

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

A01N 102
C12N 936
A61K 3803

US Classification:

435 2

Abstract:

The present invention is directed to methods for partitioning advanced glycosylation endproducts out of a biological sample using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and particular fragments thereof, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to therapeutic methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain to remove AGEs from biological material. The invention further relates to compositions and devices for partitioning AGEs away from a sample.

US Patent:

58913416, Apr 6, 1999

Filed:

Apr 5, 1996

Appl. No.:

8/628380

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

B01D 1104
A01N 102

US Classification:

210646

Abstract:

The present invention is directed to compositions and devices based upon the unexpected discovery that certain antibacterial proteins, in particular lysozyme and lactoferrin, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions and devices having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain. The invention further relates to compositions and devices for partitioning AGEs away from a sample.

US Patent:

20170185662, Jun 29, 2017

Filed:

Mar 1, 2016

Appl. No.:

15/057194

Inventors:

- Armonk NY, US
XIN JIN - WEST WINDSOR NJ, US
JEFF J. LI - PARKLAND FL, US
YONG LI - NEWTON MA, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 17/30

Abstract:

A data system can include a JavaScript Object Notation (JSON) data source, a cluster computing system, and a hierarchical JSON handler. The schema of the JSON data source can include a hierarchically-structured element having a nested array. The cluster computing system can store datasets across multiple nodes for parallel manipulation. The datasets can have a flat structure and can be queried using a Structured Query Language (SQL). The cluster computing system can lack the ability to directly import the hierarchically-structured element of the JSON data source into a dataset. The hierarchical JSON handler can be configured to extract and flatten the hierarchically-structured element of the JSON data source and import the extracted and flattened JSON data into one or more target datasets of the cluster computing system. The cluster computing system can then able to perform operations upon the target datasets.

Address:

91 Henry St, New York, NY 10002

Phone:

(212)2218018

VIN:

5TDKK3DC7BS091258

Make:

TOYOTA

Model:

SIENNA

Year:

2011