Yong Fang Li

US Patent:

59622458, Oct 5, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/475055

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

C12Q 134
C12Q 100
G01N 33566

US Classification:

435 18

Abstract:

The present invention is directed to methods for detecting the presence of advanced glycosylation endproducts using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and lactoferrin, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to diagnostic methods for diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain. The invention further relates to compositions and devices for partitioning AGEs away from a sample.

US Patent:

58558829, Jan 5, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/485948

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

A61K 3847
A61K 3816

US Classification:

424 9461

Abstract:

The present invention is directed to methods for inhibiting the cross-linking of advanced glycosylation endproducts in a subject suspected of having elevated levels of AGEs by using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and particular fragments thereof, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to therapeutic methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain to remove AGEs from biological material. The invention further relates to compositions for inhibiting the cross-linking of AGEs in a subject in need of such therapy.

US Patent:

58612386, Jan 19, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/487058

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

A01N 102
C12N 936
A61K 3803

US Classification:

435 2

Abstract:

The present invention is directed to methods for partitioning advanced glycosylation endproducts out of a biological sample using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and particular fragments thereof, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to therapeutic methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain to remove AGEs from biological material. The invention further relates to compositions and devices for partitioning AGEs away from a sample.

US Patent:

58913416, Apr 6, 1999

Filed:

Apr 5, 1996

Appl. No.:

8/628380

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

B01D 1104
A01N 102

US Classification:

210646

Abstract:

The present invention is directed to compositions and devices based upon the unexpected discovery that certain antibacterial proteins, in particular lysozyme and lactoferrin, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions and devices having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain. The invention further relates to compositions and devices for partitioning AGEs away from a sample.

US Patent:

20140282563, Sep 18, 2014

Filed:

Mar 15, 2013

Appl. No.:

13/842960

Inventors:

INTERNATIONAL BUSINESS MACHINES CORPORATION - Armonk NY, US
Yong Li - Newton MA, US
Shyam R. Mudambi - Wayland MA, US
Xiaoyan Pu - Chelmsford MA, US

Assignee:

INTERNATIONAL BUSINESS MACHINES CORPORATION - Armonk NY

International Classification:

G06F 9/48

US Classification:

718102

Abstract:

System, method, and computer program product to process parallel computing tasks on a distributed computing system, by computing an execution plan for a parallel computing job to be executed on the distributed computing system, the distributed computing system comprising a plurality of compute nodes, generating, based on the execution plan, an ordered set of tasks, the ordered set of tasks comprising: (i) configuration tasks, and (ii) execution tasks for executing the parallel computing job on the distributed computing system, and launching a distributed computing application to assign the tasks of the ordered set of tasks to the plurality of compute nodes to execute the parallel computing job on the distributed computing system.

Address:

7421 44 Ave #3FL, Elmhurst, NY 11373

Phone:

(917)8330692

VIN:

4T3ZK3BB4CU047467

Make:

TOYOTA

Model:

VENZA

Year:

2012

Address:

4831 Bell Blvd, Oakland Gardens, NY 11364

VIN:

5GTEN13E998102683

Make:

HUMMER

Model:

H3

Year:

2009