Yong Ji Li

US Patent:

20220233529, Jul 28, 2022

Filed:

Dec 29, 2021

Appl. No.:

17/564549

Inventors:

- Wilmington DE, US
Juan Carlos Almagro - Cambridge MA, US
Rebecca A. Buonpane - Wilmington DE, US
Peter Niels Carlsen - Claymont DE, US
Taisheng Huang - Wilmington DE, US
Yong Li - Newark DE, US
Horacio G. Nastri - West Chester PA, US
Chao Qi - Newark DE, US
Shaun M. Stewart - Chadds Ford PA, US
Xiaozhao Wang - Mt. Laurel NJ, US
Liangxing Wu - Wilmington DE, US
Wenqing Yao - Chadds Ford PA, US
Jing Zhou - Boxborough MA, US
Wenyu Zhu - Media PA, US

International Classification:

A61K 31/501
A61P 35/00
A61K 39/395
C07K 16/28

Abstract:

Disclosed are combination therapies comprising administration of a CD73 inhibitor, an adenosine A2A or A2B receptor inhibitor, and a PD-1/PD-L1 inhibitor. The disclosed combination therapies are useful in the treatment of diseases related to the activity of adenosine receptors and/or CD73 and/or PD-1/PD-L1 including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases. Anti-CD73 antibodies, PD-1/PD-L1 inhibitors, and A2A/A2B inhibitors are also disclosed.

US Patent:

20210205311, Jul 8, 2021

Filed:

Dec 30, 2020

Appl. No.:

17/138485

Inventors:

- Wilmington DE, US
Juan Carlos Almagro - Cambridge MA, US
Rebecca A. Buonpane - Wilmington DE, US
Peter Niels Carlsen - Claymont DE, US
Taisheng Huang - Wilmington DE, US
Yong Li - Newark DE, US
Luping Lin - Garnet Valley PA, US
Horacio G. Nastri - West Chester PA, US
Chao Qi - Newark DE, US
Shaun M. Stewart - Chadds Ford PA, US
Pramod Unnikrishnan Thekkat - Chadds Ford PA, US
Xiaozhao Wang - Mt. Laurel NJ, US
Liangxing Wu - Wilmington DE, US
Wenqing Yao - Chadds Ford PA, US
Jing Zhou - Boxborough MA, US
Wenyu Zhu - Media PA, US

International Classification:

A61K 31/519
A61K 39/395
A61P 35/00
A61K 31/501
A61K 31/506
A61K 31/4985
A61K 31/444

Abstract:

The present application provides methods of treating cancer using a combination of an inhibitor of A2A and/or A2B and an inhibitor of PD-1 and/or PD-L1.

US Patent:

20200175027, Jun 4, 2020

Filed:

Dec 4, 2018

Appl. No.:

16/209325

Inventors:

- Armonk NY, US
Xiaoyan PU - Chelmsford MA, US
Yong LI - Newton MA, US
Ryan PHAM - San Jose CA, US

International Classification:

G06F 16/25
G06F 16/26
G06F 17/24

Abstract:

Mining data transformation flows in spreadsheets includes identifying operations defined in a spreadsheet, identifying source data, in the spreadsheet, on which the operations operate, automatically creating an extract, transform, load (ETL) data transformation flow, and executing the created ETL data transformation flow. Creating the ETL data transformation flow includes selecting, in the ETL system, source data endpoint(s) for data extraction, selecting target data endpoint(s) for data loading, mapping at least one of the identified operations to ETL operation(s) for data transformation, and building the ETL data transformation flow, which defines extraction from the selected source data endpoint(s), transformation based on the ETL operation(s), and loading to the selected target data endpoint(s).

US Patent:

20190368344, Dec 5, 2019

Filed:

Jul 15, 2019

Appl. No.:

16/511221

Inventors:

- Johnston RI, US
Xiaobo Nie - Burlington MA, US
Raoyang Zhang - Burlington MA, US
Yong Li - Burlington MA, US
Hiroshi Otomo - Burlington MA, US
Hudong Chen - Burlington MA, US
Andrew Fager - Burlington MA, US

International Classification:

E21B 49/00
G01V 99/00

Abstract:

This description relates to computer simulation of physical processes, such as computer simulation of multi-species flow through porous media including the determination/estimation of relative permeabilities for the multi-species flow through the porous media.

US Patent:

20190318123, Oct 17, 2019

Filed:

Jun 26, 2019

Appl. No.:

16/453908

Inventors:

- Armonk NY, US
Yong Li - Newton MA, US
Ryan Pham - San Jose CA, US
Xiaoyan Pu - Chelmsford MA, US
Yeh-Heng Sheng - Cupertino CA, US

International Classification:

G06F 21/62
G06F 16/182
G06F 9/50
G06F 9/48
H04L 29/08

Abstract:

A hybrid cluster environment with a public cloud cluster having nodes storing data and a plurality of private clusters is provided, wherein each of the plurality of private clusters has nodes storing data. Registration data that indicates a customer identifier, a new private cluster, and a file transfer server is received. The new private cluster is added to the plurality of private clusters in the hybrid cluster environment. Input to design a job to process data in the hybrid cluster environment is received. It is determined that the job is to be deployed to the new private cluster. The job is deployed to the new private cluster using the file transfer server, wherein the job is executed at the new private cluster. Job status information and one or more job logs are received with the file transfer server.

US Patent:

20190278938, Sep 12, 2019

Filed:

Mar 8, 2018

Appl. No.:

15/915428

Inventors:

- Armonk NY, US
Yong Li - Newton MA, US
Ryan Pham - San Jose CA, US
Xiaoyan Pu - Chelmsford MA, US
Yeh-Heng Sheng - Cupertino CA, US

International Classification:

G06F 21/62
G06F 9/48
G06F 9/50
G06F 17/30
H04L 29/08

Abstract:

A hybrid cluster environment with a public cloud cluster having nodes storing data and a plurality of private clusters is provided, wherein each of the plurality of private clusters has nodes storing data. Registration data that indicates a customer identifier, a new private cluster, and a file transfer server is received. The new private cluster is added to the plurality of private clusters in the hybrid cluster environment. Input to design a job to process data in the hybrid cluster environment is received. It is determined that the job is to be deployed to the new private cluster. The job is deployed to the new private cluster using the file transfer server, wherein the job is executed at the new private cluster. Job status information and one or more job logs are received with the file transfer server.

US Patent:

20170310564, Oct 26, 2017

Filed:

Jul 12, 2017

Appl. No.:

15/648368

Inventors:

- Armonk NY, US
Eric A. Jacobson - Arlington MA, US
Yong Li - Newton MA, US
Xiaoyan Pu - Chelmsford MA, US

International Classification:

H04L 12/24
G06F 9/50
G06F 9/44
H04L 29/08
G06F 9/48
H04L 12/24
G06F 9/445

Abstract:

Provided are a computer program product, system, and method for allocating physical nodes for processes in an execution plan. An execution plan is generated indicating a plurality of processes. A resource requirement is generated indicating requested physical nodes and an assignment of the processes to execute on the requested physical nodes. A determination is made from the resource requirement of a resource allocation of physical nodes for the requested physical nodes and the processes. The execution plan is updated to generate an updated execution plan indicating the physical nodes on which the processes will execute according to the received resource allocation.

US Patent:

20170075964, Mar 16, 2017

Filed:

Sep 11, 2015

Appl. No.:

14/851061

Inventors:

- Armonk NY, US
Yong Li - Newton MA, US
Xiaoyan Pu - Chelmsford MA, US
Yeh-Heng Sheng - Cupertino CA, US

International Classification:

G06F 17/30

Abstract:

A system includes at least one processor and processes an ETL job. The system analyzes a specification of the ETL job including one or more functional expressions to load data from one or more source data stores, process the data in memory, and store the processed data to one or more target data stores. One or more data flows are produced from the specification based on the one or more functional expressions. The one or more data flows utilize in-memory distributed data sets generated to accommodate parallel processing for loading and processing the data. The one or more data flows are optimized to assign operations to be performed on the one or more source data stores. The optimized data flows are executed to load the data to the one or more target data stores in accordance with the specification. Present invention embodiments further include methods and computer program products.