Yong S Li

US Patent:

20130174140, Jul 4, 2013

Filed:

Jan 3, 2012

Appl. No.:

13/342567

Inventors:

Rand K. Barthel - Mendon MA, US
Yong Li - Newton MA, US
Eduardo N. Spring - Round Rock TX, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 9/445

US Classification:

717174

Abstract:

Timing parameters that influence an install time interval for installing a product on computing machines in a test environment in accordance with an installation configuration option are identified. A test value of the timing parameter and a test value of the install time are determined for each of the computing machines. The test values of the timing parameter and the install time determined for the sample computing machines are analyzed to determine an install time calculation expression for the installation configuration option. For installation in accordance with the installation configuration option in a normal operating environment, a current value of each of the timing parameters of the predetermined install time calculation expression for the installation configuration option. The install time interval in the normal operating environment is estimated based on the current value of the timing parameters and the install time calculation expression.

US Patent:

59622458, Oct 5, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/475055

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

C12Q 134
C12Q 100
G01N 33566

US Classification:

435 18

Abstract:

The present invention is directed to methods for detecting the presence of advanced glycosylation endproducts using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and lactoferrin, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to diagnostic methods for diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain. The invention further relates to compositions and devices for partitioning AGEs away from a sample.

US Patent:

58558829, Jan 5, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/485948

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

A61K 3847
A61K 3816

US Classification:

424 9461

Abstract:

The present invention is directed to methods for inhibiting the cross-linking of advanced glycosylation endproducts in a subject suspected of having elevated levels of AGEs by using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and particular fragments thereof, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to therapeutic methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain to remove AGEs from biological material. The invention further relates to compositions for inhibiting the cross-linking of AGEs in a subject in need of such therapy.

US Patent:

58612386, Jan 19, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/487058

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

A01N 102
C12N 936
A61K 3803

US Classification:

435 2

Abstract:

The present invention is directed to methods for partitioning advanced glycosylation endproducts out of a biological sample using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and particular fragments thereof, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to therapeutic methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain to remove AGEs from biological material. The invention further relates to compositions and devices for partitioning AGEs away from a sample.

US Patent:

58913416, Apr 6, 1999

Filed:

Apr 5, 1996

Appl. No.:

8/628380

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

B01D 1104
A01N 102

US Classification:

210646

Abstract:

The present invention is directed to compositions and devices based upon the unexpected discovery that certain antibacterial proteins, in particular lysozyme and lactoferrin, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions and devices having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain. The invention further relates to compositions and devices for partitioning AGEs away from a sample.

US Patent:

20220233529, Jul 28, 2022

Filed:

Dec 29, 2021

Appl. No.:

17/564549

Inventors:

- Wilmington DE, US
Juan Carlos Almagro - Cambridge MA, US
Rebecca A. Buonpane - Wilmington DE, US
Peter Niels Carlsen - Claymont DE, US
Taisheng Huang - Wilmington DE, US
Yong Li - Newark DE, US
Horacio G. Nastri - West Chester PA, US
Chao Qi - Newark DE, US
Shaun M. Stewart - Chadds Ford PA, US
Xiaozhao Wang - Mt. Laurel NJ, US
Liangxing Wu - Wilmington DE, US
Wenqing Yao - Chadds Ford PA, US
Jing Zhou - Boxborough MA, US
Wenyu Zhu - Media PA, US

International Classification:

A61K 31/501
A61P 35/00
A61K 39/395
C07K 16/28

Abstract:

Disclosed are combination therapies comprising administration of a CD73 inhibitor, an adenosine A2A or A2B receptor inhibitor, and a PD-1/PD-L1 inhibitor. The disclosed combination therapies are useful in the treatment of diseases related to the activity of adenosine receptors and/or CD73 and/or PD-1/PD-L1 including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases. Anti-CD73 antibodies, PD-1/PD-L1 inhibitors, and A2A/A2B inhibitors are also disclosed.

US Patent:

20210205311, Jul 8, 2021

Filed:

Dec 30, 2020

Appl. No.:

17/138485

Inventors:

- Wilmington DE, US
Juan Carlos Almagro - Cambridge MA, US
Rebecca A. Buonpane - Wilmington DE, US
Peter Niels Carlsen - Claymont DE, US
Taisheng Huang - Wilmington DE, US
Yong Li - Newark DE, US
Luping Lin - Garnet Valley PA, US
Horacio G. Nastri - West Chester PA, US
Chao Qi - Newark DE, US
Shaun M. Stewart - Chadds Ford PA, US
Pramod Unnikrishnan Thekkat - Chadds Ford PA, US
Xiaozhao Wang - Mt. Laurel NJ, US
Liangxing Wu - Wilmington DE, US
Wenqing Yao - Chadds Ford PA, US
Jing Zhou - Boxborough MA, US
Wenyu Zhu - Media PA, US

International Classification:

A61K 31/519
A61K 39/395
A61P 35/00
A61K 31/501
A61K 31/506
A61K 31/4985
A61K 31/444

Abstract:

The present application provides methods of treating cancer using a combination of an inhibitor of A2A and/or A2B and an inhibitor of PD-1 and/or PD-L1.

US Patent:

20200175027, Jun 4, 2020

Filed:

Dec 4, 2018

Appl. No.:

16/209325

Inventors:

- Armonk NY, US
Xiaoyan PU - Chelmsford MA, US
Yong LI - Newton MA, US
Ryan PHAM - San Jose CA, US

International Classification:

G06F 16/25
G06F 16/26
G06F 17/24

Abstract:

Mining data transformation flows in spreadsheets includes identifying operations defined in a spreadsheet, identifying source data, in the spreadsheet, on which the operations operate, automatically creating an extract, transform, load (ETL) data transformation flow, and executing the created ETL data transformation flow. Creating the ETL data transformation flow includes selecting, in the ETL system, source data endpoint(s) for data extraction, selecting target data endpoint(s) for data loading, mapping at least one of the identified operations to ETL operation(s) for data transformation, and building the ETL data transformation flow, which defines extraction from the selected source data endpoint(s), transformation based on the ETL operation(s), and loading to the selected target data endpoint(s).