Yong Shun Li

US Patent:

7582611, Sep 1, 2009

Filed:

May 2, 2006

Appl. No.:

11/416519

Inventors:

Yaoquan Liu - Castro Valley CA, US
Christopher Carreras - Belmont CA, US
David C. Myles - Kensington CA, US
Yong Li - Palo Alto CA, US
Simon James Shaw - San Francisco CA, US
Hong Fu - Union City CA, US
Yue Chen - Hayward CA, US
Hao Zheng - Hayward CA, US
Yandong Li - San Jose CA, US
Mark A. Burlingame - Oakland CA, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

A61K 31/70
C07H 17/08

US Classification:

514 29, 536 72, 536 73, 536 74

Abstract:

Compounds having a structure according to formula (I).

US Patent:

7955824, Jun 7, 2011

Filed:

May 9, 2008

Appl. No.:

12/118432

Inventors:

John R. Carney - Hayward CA, US
Yong Li - Hayward CA, US
Hugo Menzella - Hayward CA, US
Ralph C. Reid - Hayward CA, US

Assignee:

Kosan Biosciences Incorporated - Princeton NJ

International Classification:

C12P 17/06

US Classification:

435125, 549292, 549417, 558250, 558254

Abstract:

The invention provides novel compounds that may be used as intermediates in the preparation of epothilones, epothilone analogs and derivative, as well as new synthetic methods for producing the intermediates and products.

US Patent:

8030503, Oct 4, 2011

Filed:

May 9, 2008

Appl. No.:

12/117876

Inventors:

Yue Chen - Hayward CA, US
Yong Li - Palo Alto CA, US

Assignee:

Kosan Biosciences Incorporated - Princeton NJ

International Classification:

C07D 309/30

US Classification:

549292

Abstract:

Intermediates in the preparation of epothilones and epothilone analogs are provided along with synthetic methods useful in the synthesis of epothilone compounds.

US Patent:

20020128213, Sep 12, 2002

Filed:

Sep 24, 2001

Appl. No.:

09/969177

Inventors:

Leonard Katz - Oakland CA, US
Gary Ashley - Alameda CA, US
Mark Burlingame - San Francisco CA, US
Steven Dong - San Francisco CA, US
Hong Fu - Union City CA, US
Yong Li - Palo Alto CA, US
David Myles - Kensington CA, US

International Classification:

A61K031/7048
C07H017/08

US Classification:

514/030000, 536/007100

Abstract:

The present invention provides novel sixteen-membered macrolide compounds that are useful as anti-infective agents or as intermediates thereto. The present invention also provides methods for the preparation of these compounds, and methods and formulations for their use. In one aspect of the present invention, sixteen-membered macrolide possessing a side chain Z are provided where Z is aliphatic, aryl, alkylaryl, halide, NOR, NNHR, or —W—Rwhere W is O, S, NC( O)R, NC( O)OR, NC( O)NHRor NRwhere Rand Rare each independently hydrogen, aliphatic, aryl or alkylaryl. In another aspect of the present invention, bicyclic compounds are provided where one of the cyclic-components is a sixteen-membered macrolide and the other is a cyclic moiety whose cyclic structure is formed by between 3 and 10 atoms. In another aspect of the present invention, sixteen-membered macrolide compounds that bind to the domain II region of the 23S RNA are provided.