Yong F Li

US Patent:

59622458, Oct 5, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/475055

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

C12Q 134
C12Q 100
G01N 33566

US Classification:

435 18

Abstract:

The present invention is directed to methods for detecting the presence of advanced glycosylation endproducts using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and lactoferrin, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to diagnostic methods for diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain. The invention further relates to compositions and devices for partitioning AGEs away from a sample.

US Patent:

58558829, Jan 5, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/485948

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

A61K 3847
A61K 3816

US Classification:

424 9461

Abstract:

The present invention is directed to methods for inhibiting the cross-linking of advanced glycosylation endproducts in a subject suspected of having elevated levels of AGEs by using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and particular fragments thereof, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to therapeutic methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain to remove AGEs from biological material. The invention further relates to compositions for inhibiting the cross-linking of AGEs in a subject in need of such therapy.

US Patent:

58612386, Jan 19, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/487058

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

A01N 102
C12N 936
A61K 3803

US Classification:

435 2

Abstract:

The present invention is directed to methods for partitioning advanced glycosylation endproducts out of a biological sample using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and particular fragments thereof, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to therapeutic methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain to remove AGEs from biological material. The invention further relates to compositions and devices for partitioning AGEs away from a sample.

US Patent:

58913416, Apr 6, 1999

Filed:

Apr 5, 1996

Appl. No.:

8/628380

Inventors:

Yong Ming Li - Fresh Meadows NY
Helen Vlassara - Shelter Island NY
Anthony Cerami - Shelter Island NY

Assignee:

The Picower Institute for Medical Research - Manhasset NY

International Classification:

B01D 1104
A01N 102

US Classification:

210646

Abstract:

The present invention is directed to compositions and devices based upon the unexpected discovery that certain antibacterial proteins, in particular lysozyme and lactoferrin, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions and devices having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain. The invention further relates to compositions and devices for partitioning AGEs away from a sample.

US Patent:

20200336190, Oct 22, 2020

Filed:

Jun 22, 2020

Appl. No.:

16/908561

Inventors:

- San Diego CA, US
Juergen CEZANNE - Ocean Township NJ, US
Junyi LI - Chester NJ, US
Sundar SUBRAMANIAN - San Diego CA, US
Tao LUO - San Diego CA, US
Raghu Narayan CHALLA - San Diego CA, US
Ruhua HE - San Diego CA, US
Yong LI - San Diego CA, US
Jun ZHU - San Diego CA, US
Tianyang BAI - Bridgewater NJ, US

International Classification:

H04B 7/06
H04B 17/327
H04W 72/08
H04W 72/04
H04W 24/10

Abstract:

Aspects of the disclosure relate to a method of operating a scheduled entity for wireless communication. In some aspects, the scheduled entity detects a fluctuation in a beam strength of at least one transmit beam from a scheduling entity. The scheduled entity transmits a first message to the scheduling entity, the first message indicating at least the fluctuation in the beam strength of the at least one transmit beam from the scheduling entity.

US Patent:

20190245605, Aug 8, 2019

Filed:

Feb 4, 2019

Appl. No.:

16/267303

Inventors:

- San Diego CA, US
Juergen CEZANNE - Ocean Township NJ, US
Junyi LI - Chester NJ, US
Sundar SUBRAMANIAN - San Diego CA, US
Tao LUO - San Diego CA, US
Raghu CHALLA - San Diego CA, US
Ruhua HE - San Diego CA, US
Yong LI - San Diego CA, US
Jun ZHU - San Diego CA, US
Tianyang BAI - Bridgewater NJ, US

International Classification:

H04B 7/06
H04B 17/327
H04W 24/10
H04W 72/04
H04W 72/08

Abstract:

Aspects of the disclosure relate to a method of operating a scheduled entity for wireless communication. In some aspects, the scheduled entity detects a fluctuation in a beam strength of at least one transmit beam from a scheduling entity. The scheduled entity transmits a first message to the scheduling entity, the first message indicating at least the fluctuation in the beam strength of the at least one transmit beam from the scheduling entity.

US Patent:

20170185662, Jun 29, 2017

Filed:

Mar 1, 2016

Appl. No.:

15/057194

Inventors:

- Armonk NY, US
XIN JIN - WEST WINDSOR NJ, US
JEFF J. LI - PARKLAND FL, US
YONG LI - NEWTON MA, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 17/30

Abstract:

A data system can include a JavaScript Object Notation (JSON) data source, a cluster computing system, and a hierarchical JSON handler. The schema of the JSON data source can include a hierarchically-structured element having a nested array. The cluster computing system can store datasets across multiple nodes for parallel manipulation. The datasets can have a flat structure and can be queried using a Structured Query Language (SQL). The cluster computing system can lack the ability to directly import the hierarchically-structured element of the JSON data source into a dataset. The hierarchical JSON handler can be configured to extract and flatten the hierarchically-structured element of the JSON data source and import the extracted and flattened JSON data into one or more target datasets of the cluster computing system. The cluster computing system can then able to perform operations upon the target datasets.

US Patent:

20140282563, Sep 18, 2014

Filed:

Mar 15, 2013

Appl. No.:

13/842960

Inventors:

INTERNATIONAL BUSINESS MACHINES CORPORATION - Armonk NY, US
Yong Li - Newton MA, US
Shyam R. Mudambi - Wayland MA, US
Xiaoyan Pu - Chelmsford MA, US

Assignee:

INTERNATIONAL BUSINESS MACHINES CORPORATION - Armonk NY

International Classification:

G06F 9/48

US Classification:

718102

Abstract:

System, method, and computer program product to process parallel computing tasks on a distributed computing system, by computing an execution plan for a parallel computing job to be executed on the distributed computing system, the distributed computing system comprising a plurality of compute nodes, generating, based on the execution plan, an ordered set of tasks, the ordered set of tasks comprising: (i) configuration tasks, and (ii) execution tasks for executing the parallel computing job on the distributed computing system, and launching a distributed computing application to assign the tasks of the ordered set of tasks to the plurality of compute nodes to execute the parallel computing job on the distributed computing system.