Yong Anthony Yu

US Patent:

6984374, Jan 10, 2006

Filed:

Jan 30, 2003

Appl. No.:

10/356245

Inventors:

Aladar A. Szalay - Highland CA, US
Shahrokh Shabahang - Redlands CA, US
Yong Yu - Loma Linda CA, US

Assignee:

Loma Linda University - Loma Linda CA

International Classification:

A61K 49/00
A61B 5/055
A61B 10/00
A61B 5/00
A61B 8/00

US Classification:

424 91, 424 9341, 424 9351, 424 96, 435 4, 435 72, 435 732, 435 795, 435 29, 435 31, 435 32, 435 34, 4351731, 435243, 4353201, 436164, 436171, 436172

Abstract:

A method for the evaluation of a material to determine whether the material is susceptible to bacterial contamination or colonization comprising providing bacteria which are modified to produce a first detectable signal, exposing the material being evaluated to the bacteria and determining whether the first signal is present determining whether the first signal is present on the material or within the material.

US Patent:

7588767, Sep 15, 2009

Filed:

Jun 18, 2004

Appl. No.:

10/872156

Inventors:

Aladar A. Szalay - Highland CA, US
Tatyana Timiryasova - San Diego CA, US
Yong A. Yu - San Diego CA, US
Qian Zhang - San Diego CA, US

Assignee:

Genelux Corporation - San Diego CA

International Classification:

A01N 63/00
A61K 39/12
A61K 39/275
A61K 39/00
G01N 33/574
A61K 39/145

US Classification:

4241991, 4242321, 4242051, 424 933, 4242771, 435 723

Abstract:

Therapeutic methods and microorganisms therefore are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proliferating tissues, particularly tumors, to produce selected proteins and other products. Methods for making tumor specific antibodies and also methods of making gene products encoded by the microorganism as well as antibodies reactive therewith are provided.

US Patent:

7588771, Sep 15, 2009

Filed:

Sep 27, 2005

Appl. No.:

11/238025

Inventors:

Aladar A. Szalay - Highland CA, US
Tatyana Timiryasova - Scotrun PA, US
Yong A. Yu - San Diego CA, US
Qian Zhang - San Diego CA, US

Assignee:

Genelux Corporation - San Diego CA

International Classification:

A61K 39/285
A61K 39/385
A61K 39/12
A61K 39/20

US Classification:

4242321, 42419611, 4241991, 424 931

Abstract:

Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.

US Patent:

7662398, Feb 16, 2010

Filed:

Sep 27, 2006

Appl. No.:

11/529662

Inventors:

Aladar A. Szalay - Highland CA, US
Tatyana Timiryasova - Scotrun PA, US
Yong A. Yu - San Diego CA, US
Qian Zhang - San Diego CA, US

Assignee:

Genelux Corporation - San Diego CA

International Classification:

A61K 39/285
A61K 39/385
A61K 39/12
A01N 65/00
A61K 39/20

US Classification:

4242321, 42419611, 4241991, 424 931

Abstract:

Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.

US Patent:

7754221, Jul 13, 2010

Filed:

Jul 28, 2009

Appl. No.:

12/462074

Inventors:

Aladar A. Szalay - Highland CA, US
Tatyana Timiryasova - Scotrun PA, US
Yong A. Yu - San Diego CA, US
Qian Zhang - San Diego CA, US

Assignee:

Genelux Corporation - San Diego CA

International Classification:

A01N 63/00
A61K 39/12
A61K 39/275
A61K 39/00
G01N 33/574
A61K 39/145

US Classification:

4241991, 4242321, 4242051, 424 933, 4242771, 435 723

Abstract:

Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.

US Patent:

7763420, Jul 27, 2010

Filed:

Jul 11, 2007

Appl. No.:

11/827518

Inventors:

Jochen Harald Stritzker - Kissing, DE
Phil Hill - West Bridgford, GB
Aladar A. Szalay - Highland CA, US
Yong A. Yu - San Diego CA, US

Assignee:

Genelux Corporation - San Diego CA

International Classification:

C12Q 1/00
C12Q 1/66
A61K 39/108

US Classification:

435 4, 424 91, 424 92, 4242341, 4242411, 435 8, 435 29

Abstract:

Described herein are methods for detecting a microorganism or cell in a subject and methods for detecting, imaging or diagnosing a site, disease, disorder or condition in a subject using microorganisms or cells. Also described are methods which use microorganisms or cells for treating a disease, disorder or condition. Such sites, diseases and disorders include sites of cell proliferation, proliferative conditions, neoplasms, tumors, neoplastic disease, wounds and inflammation. Further described are microorganisms and cells for use in the methods and compositions, combinations and kits, including diagnostic and pharmaceutical compositions, containing a microorganism or cell. Microorganisms and cells described herein include those that bind, sequester or accumulate metal, such as those that provide for metal acquisition, transport, storage and/or metabolism. Additional imaging and therapy agents are also described.

US Patent:

7820184, Oct 26, 2010

Filed:

Jan 11, 2008

Appl. No.:

12/008659

Inventors:

Jochen Harald Stritzker - Kissing, DE
Phil Hill - West Bridgford, GB
Aladar A. Szalay - Highland CA, US
Yong A. Yu - San Diego CA, US

Assignee:

Genelux Corporation - San Diego CA

International Classification:

A61K 39/108
A61K 49/00
C12Q 1/00

US Classification:

4242411, 424 91, 424 92, 4242341, 435 4, 435 8, 435 29

Abstract:

Methods for detecting a microorganism or cell in a subject and methods for detecting, imaging or diagnosing a site, disease, disorder or condition in a subject using microorganisms or cells and methods that microorganisms or cells for treating a disease, disorder or condition are provided. Sites, diseases and disorders include sites of cell proliferation, proliferative conditions, neoplasms, tumors, neoplastic disease, wounds and inflammation. Also provided are microorganisms and cells for use in the methods and compositions, combinations and kits, including diagnostic and pharmaceutical compositions, containing a microorganism or cell.

US Patent:

8021662, Sep 20, 2011

Filed:

Apr 25, 2007

Appl. No.:

11/796027

Inventors:

Aladar A. Szalay - Highland CA, US
Tatyana Timiryasova - San Diego CA, US
Yong A. Yu - San Diego CA, US
Qian Zhang - San Diego CA, US

Assignee:

Genelux Corporation - San Diego CA

International Classification:

A61K 39/395
A61K 39/12
A61K 39/275
C12P 21/00
C12Q 1/66
A61K 39/285

US Classification:

4241381, 4241401, 4242041, 4242321, 4241991, 800 6, 435 8

Abstract:

Methods for production of tumor-specific antibodies are provided. The methods employ microorganisms that are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proliferating tissues, particularly tumors, to produce selected proteins and other products.