Yong Ming Zhang

US Patent:

20200270353, Aug 27, 2020

Filed:

Mar 30, 2020

Appl. No.:

16/835171

Inventors:

- La Jolla CA, US
Yong ZHANG - Temple City CA, US
Yan LIU - San Diego CA, US
Peter G. SCHULTZ - La Jolla CA, US

International Classification:

C07K 16/28
C07K 14/81
C07K 14/64
C07K 14/605
C07K 14/47
C07K 16/32
C07K 14/61
C07K 14/435
C07K 14/575
C07K 14/535
C07K 14/505
A61K 47/68
A61K 47/65
C07K 14/705
C07K 16/10
A61K 39/395

Abstract:

Disclosed herein are immunoglobulin fusion proteins comprising a first antibody region, a first therapeutic agent, and a first connecting peptide; wherein the first therapeutic agent is attached to the first antibody region by the connecting peptide; and wherein the connecting peptide does not comprise a region having beta strand secondary structure. The connecting peptide may comprise an extender peptide. The extender peptide may have an alpha helical secondary structure. The connecting peptide may comprise a linker peptide. The linker peptide may not comprise any secondary structure. Also disclosed herein are compositions comprising the immunoglobulin fusion proteins and methods for using the immunoglobulin fusion proteins for the treatment or prevention of a disease or condition in a subject.

US Patent:

20150376264, Dec 31, 2015

Filed:

Jan 10, 2014

Appl. No.:

14/760115

Inventors:

- La Jolla CA, US
Yong ZHANG - Temple City CA, US
Peter G. SCHULTZ - La Jolla CA, US

International Classification:

C07K 16/00
C07K 7/08
C07K 14/64
C07K 14/81
C07K 14/575
C07K 14/61

Abstract:

Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into the CDR3H. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a stalk domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said stalk domain of the CDR3H. Also described herein are methods and compositions comprising the immunoglobulin constructs described herein for treatment and prevention of a disease or condition in a subject.