Yoon Jung Lee

US Patent:

8524697, Sep 3, 2013

Filed:

Dec 18, 2008

Appl. No.:

12/736063

Inventors:

John C. Anthes - Cranford NJ, US
Kevin D. McCormick - Basking Ridge NJ, US
John A. Hey - Edmond OK, US
Robert G. Aslanian - Rockaway NJ, US
Purakkattle J. Biju - Piscataway NJ, US
Michael Y. Berlin - Flemington NJ, US
Hongwu Yang - Westfield NJ, US
Yeon-Hee Lim - Woodbridge NJ, US
Yoon Joo Lee - Scotch Plains NJ, US
Rema Danielle Bitar - Clifton NJ, US
Phillippa H. Solomon - Edison NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A01N 43/00
A61K 31/33
C07D 215/00
C07D 277/62

US Classification:

514183, 546157, 548160

Abstract:

The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, or isomers of said compounds), having the general structure:.

US Patent:

20110262368, Oct 27, 2011

Filed:

Dec 18, 2008

Appl. No.:

12/736064

Inventors:

John C. Anthes - Cranford NJ, US
Kevin D. McCormick - Basking Ridge NJ, US
John A. Hey - Edmond OK, US
Robert G. Aslanian - Rickaway NJ, US
Purakkattle J. Biju - Piscataway NJ, US
Michael Y. Berlin - Flemington NJ, US
Daniel M. Solomon - Edison NJ, US
Philippa H. Solomon - Edison NJ, US
Hongwu Yang - Westfield NJ, US
Yeon-Hee Lim - Woodbridge NJ, US
Yoon Joo Lee - Scotch Plains NJ, US
Rema Danielle Bitar - Clifton NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/58
C07J 31/00
A61K 31/573
A61P 25/00
A61P 27/02
A61P 27/14
A61P 29/00
A61P 11/06
A61P 11/00
A61P 17/00
A61P 17/06
A61P 17/04
A61P 31/12
A61P 31/00
A61P 11/02
A61P 37/06
A61P 37/08
A61P 11/10
C07J 43/00

US Classification:

424 43, 540108, 540111, 540 63, 552581, 514176, 514174, 514179

Abstract:

The present invention provides compounds of Formula (VII) and 11-keto analogs thereof, and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, and isomers of said compounds and said 11-keto analogs, having the general structure formula (VII): wherein L, R, R, R, R, and Rare selected independently of each other and as defined herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions. The novel compounds of the present invention possess useful pharmacological activity while having unexpectedly low systemic activity. Thus, the compounds of the invention represent a safer alternative to those known glucocorticoids which have poor side-effect profiles.

US Patent:

20120171126, Jul 5, 2012

Filed:

Jun 15, 2010

Appl. No.:

13/378893

Inventors:

Michael Y. Berlin - Kenilworth NJ, US
Yeon-Hee Lim - Kenilworth NJ, US
Rema D. Bitar - Kenilworth NJ, US
Kevin D. McCormick - Kenilworth NJ, US
Robert G. Aslanian - Kenilworth NJ, US
Yoon Joo Lee - Kenilworth NJ, US
Junying Zheng - Kenilworth NJ, US
Ying Huang - Kenilworth NJ, US
Walter Won - Kenilworth NJ, US

International Classification:

A61K 31/58
A61K 9/12
A61P 37/00
A61P 29/00
A61P 17/00
A61P 17/06
A61P 17/04
A61P 11/06
A61P 11/02
A61P 11/08
A61P 11/00
A61P 1/00
A61P 1/04
A61P 25/00
A61P 27/02
C07J 71/00

US Classification:

424 45, 540 53, 514176, 514171

Abstract:

The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, or isomers of said compounds), having the general structure: Formula (I) wherein L, R, R, R, R, R, and Rare selected independently of each other and as defined herein. The present invention also provides compounds (and salts, solvates, esters, prodrugs, tautomers, and isomers) of Formulas (H-A), (II-A1), (II-A2), (II-A2.1), (ll-A-2.2), (ll-A-2.3), (II-A4), (H-B), (H-C), (III), (IV), (V), (VI), as described herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions.