Abstract:
Compounds of formula (1) are provided: wherein R and R are H, OH, F, Cl, Br, I, 1 to 6 carbon alkyl or alkenyl, 1 to 6 carbon alkoxy, aryl, OR , nitro, amino, CF or R and R are taken together to form a fused ring at the 2,3- or 3,4-positions providing a fused phenyl group or a benzodioxane group, or a 4- or 7-substituted indole group, or a 5- or 8-substituted quinoline group; R represents a group selected from hydrogen, a 1 to 6 carbon alkyl, a 1 to 4 carbon alkoxy or a halogen; R represents a group selected from hydrogen, 1 to 6 carbon alkyl or R ; R5 is CH Ph in which the phenyl ring can be optionally substituted by a group selected from OMe, halogen, CF ; X is selected from a group represented by C, CR , [[CHR ]] and CHCH ; A is selected from a group represented by N, NH, CH and CH ; B is selected from a group represented by O, S, H and H2; or A and B may be concatenated together to form indole, benzimidazole, indolone or indoline moieties; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods of treating central nervous system disorders utilizing these compounds.