Young Kyung Ko

US Patent:

20080213350, Sep 4, 2008

Filed:

Feb 20, 2008

Appl. No.:

12/070602

Inventors:

Young Tag Ko - Boston MA, US
Ulrich Bickel - Amarillo TX, US

Assignee:

Texas Tech University System - Lubbock TX

International Classification:

A61K 9/127

US Classification:

424450

Abstract:

Complexes of nucleic acid and cationic polymer, which are encapsulated in liposomes for the purpose of delivering nucleic acid and methods for producing encapsulated complexes.

US Patent:

20100285111, Nov 11, 2010

Filed:

Nov 10, 2008

Appl. No.:

12/741778

Inventors:

Young Tag Ko - Brighton MA, US
Amit Kale - Waltham MA, US
Vladimir Torchilin - Charlestown MA, US

Assignee:

Northeastern University - Boston MA

International Classification:

A61K 31/7088
A61K 9/14
C12N 15/63
C12N 15/64
C08G 73/00
A61K 9/127
A61P 35/00

US Classification:

424450, 514 44 R, 424497, 4353201, 435440, 525451, 525 542

Abstract:

Nanoparticles containing nucleic acid and suitable for use as in vivo delivery agents for nucleic acids are provided. The nanoparticles use a covalent conjugate of a polycation such as polyethylenimine and phospholipids. The final DNA-containing nanoparticle has a vesicular structure with a polyplex core surrounded by a mixed lipid/PEG-lipid monolayer envelope and offers simple preparation, high loading capacity, and in vivo stability. The nanoparticles have good in vivo stability and a prolonged blood circulation time and can effectively deliver a gene to a biological target such as a tumor.

US Patent:

20220191185, Jun 16, 2022

Filed:

Dec 16, 2020

Appl. No.:

17/123622

Inventors:

- REDMOND WA, US
JOSEPH ISENHOUR - REDMOND WA, US
AAKASHI KAPOOR - SEATTLE WA, US
YOUNG MOON KO - SAMMAMISH WA, US
SAGAR BHOLANATH SAHA - RENTON WA, US
STEVEN SYFUHS - SEATTLE WA, US

International Classification:

H04L 29/06

Abstract:

An identity provider of a cloud computing service provides authentication for on-premise applications that is subject to a legacy authentication protocol that differs from the cloud-based network authentication protocol used by the identity provider. The identity provider generates a security ticket for use to gain access to the on-premise application. The security ticket is embedded in a security token associated with a cloud-based network authentication protocol. A client application seeking access to the on-premise application extracts the embedded security ticket from the security token which is then used to access the on-premise application via a legacy authentication protocol.