Young D Kwon

US Patent:

8318156, Nov 27, 2012

Filed:

Jul 10, 2007

Appl. No.:

12/373510

Inventors:

Donald W Landry - New York NY, US
Joanne MacDonald - New York NY, US
Daquan Gao - Louisville KY, US
James H. Woods - Ann Arbor MI, US
Roger K. Sunahara - Ann Arbor MI, US
Diwahar L. Narasimhan - Ann Arbor MI, US
Victor Yang - Ann Arbor MI, US
Mei-Chuan Holden Ko - Ann Arbor MI, US
John J. Tesmer - Ann Arbor MI, US
Tien-Yi Lee - Ann Arbor MI, US
Young Min Kwon - Ann Arbor MI, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY
The Regents of the University of Michigan - Ann Arbor MI
University of Kentucky Research Foundation - Lexington KY

International Classification:

A61K 38/46
A61K 38/43
C12N 9/16
C12N 9/14
C12P 21/06
C12P 19/34
C07H 21/04

US Classification:

424 946, 424 941, 435196, 435195, 435 691, 435 911, 536 231, 536 232, 530350

Abstract:

Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

US Patent:

20130136728, May 30, 2013

Filed:

Nov 14, 2012

Appl. No.:

13/676324

Inventors:

The Trustees of Columbia University in the City of - New York NY, US
James H. Woods - Ann Arbor MI, US
Roger Sunahara - Ann Arbor MI, US
Diwahar L. Narasimhan - Ann Arbor MI, US
Joanne MacDonald - New York NY, US
Victor Yang - Ann Arbor MI, US
Mei-Chuan Holden Ko - Ann Arbor MI, US
John J. Tesmer - Ann Arbor MI, US
Tien-Yi Lee - Ann Arbor MI, US
Young Min Kwon - Ann Arbor MI, US
Daquan Gao - Louisville KY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12N 9/18

US Classification:

424 946, 536 232, 435197

Abstract:

Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

US Patent:

41505670, Apr 24, 1979

Filed:

Jun 29, 1978

Appl. No.:

5/920591

Inventors:

Dusan C. Prevorsek - Morristown NJ
Young D. Kwon - Morristown NJ
Raj K. Sharma - Morristown NJ

Assignee:

Allied Chemical Corporation - Morris Township, Morris County NJ

International Classification:

G01M 1702

US Classification:

73146

Abstract:

By wheel testing two tires having different construction parameters, e. g. different tire cords and measuring the temperatures at a few points within each tire body; and by measurement with a high strain dynamic viscoelastometer, the heat generation rate and dynamic tensile moduli (at various temperatures, strain frequencies and tensions) of the cords and rubber used in each tire are determined, where the values of the exponents "X" in the general equation relating cyclic strain amplitude, S, in the tire cord and in the rubber of each tire vs. the dynamic tensile moduli, E, for cords and rubber, at given temperature can be determined in the form: S. sub. A /S. sub. B=( E. sub. B /E. sub. A). sup. X.

US Patent:

54807069, Jan 2, 1996

Filed:

Jun 16, 1994

Appl. No.:

8/260661

Inventors:

Hsin L. Li - Parsippany NJ
Young D. Kwon - Mendham NJ
Dusan C. Prevorsek - Morristown NJ

Assignee:

AlliedSignal Inc. - Morris Township NJ

International Classification:

B32B 512
B32B 700
B27N 900

US Classification:

428113

Abstract:

This invention relates to a fire resistant multilayer complex ballistic resistant article comprising at least one first layer comprised a plurality of flammable fibers a first matrix and at least one second layer which is adjacent to said first layer which comprises a plurality of fire resistant fibers in a second matrix, wherein the second matrix comprises a fire retardant material and is different from the first matrix material.

US Patent:

52601226, Nov 9, 1993

Filed:

Sep 5, 1991

Appl. No.:

7/755249

Inventors:

Dusan C. Prevorsek - Morristown NJ
Young D. Kwon - Mendham NJ
Hong B. Chin - Parsippany NJ

Assignee:

Allied-Signal Inc. - Morris Township, Morris County NJ

International Classification:

D03D 300

US Classification:

428225

Abstract:

This invention is related to a woven fibrous article which exhibits relatively low reductions in energy-to-break and tenacity on repeated impacts.

US Patent:

40569730, Nov 8, 1977

Filed:

Dec 13, 1976

Appl. No.:

5/750039

Inventors:

Dusan C. Prevorsek - Morristown NJ
Young D. Kwon - Morristown NJ
Raj K. Sharma - Morristown NJ

Assignee:

Allied Chemical Corporation - Morris Township NJ

International Classification:

G01N 334

US Classification:

73 91

Abstract:

An apparatus and method for testing viscoelastic solids, such as tire cord. The apparatus includes: holding means, pretension means, first and second displacement generators, and mechanical-electrical transforming means. The holding means holds the material in a predetermined position. The pretension means applies tension during testing. The first displacement generator has an eccentric means for applying cyclic displacement. The second displacement generator applies cyclic displacement to the material co-directional with that applied by the first displacement generator, but of smaller amplitude and higher frequency. The mechanical-electrical transforming means transforms mechanical motion into electrical signals, such as a stress signal, a strain signal and a differentiated strain signal. The apparatus may also include means for differential testing of duplicate material samples wherein one sample is subjected to cyclic displacement of both the first and second displacement generators, and the other sample is subjected to cyclic displacement of the first displacement generator only. The apparatus may further include integrating means for integration of a stress-strain hysteresis loop.

US Patent:

44407114, Apr 3, 1984

Filed:

Sep 30, 1982

Appl. No.:

6/432044

Inventors:

Young D. Kwon - Morristown NJ
Sheldon Kavesh - Whippany NJ
Dusan C. Prevorsek - Morristown NJ

Assignee:

Allied Corporation - Morris Township, Morris County NJ

International Classification:

D01F 614

US Classification:

264185

Abstract:

Polyvinyl alcohol of molecular weight over 500,000 (i. e. 1,500,000 to 2,500,000) is spun as a dilute solution (2-15%) in a relatively non-volatile solvent such as glycerin. The resultant gel fiber is extracted with a volatile solvent such as methanol and dried. Upon stretching at one or more stages during the process, fibers of tenacity above 10 g/denier and modulus above 200 g/denier (e. g. 18 and 450, respectively) are produced.

US Patent:

50063901, Apr 9, 1991

Filed:

Jun 19, 1989

Appl. No.:

7/367642

Inventors:

Sheldon Kavesh - Whippany NJ
Kwang Kim - Seoul, KR
Young D. Kwon - Morristown NJ
Dusan C. Prevorsek - Morristown NJ

Assignee:

Allied-Signal - Morris Township, Morris County NJ

International Classification:

B32B 508,12
B32B 2702

US Classification:

428105

Abstract:

The present invention relates to high strength, high modulus polyethylene filaments which form composites having improved shear strength and composites formed from said filaments.