Yu Chen

US Patent:

6406861, Jun 18, 2002

Filed:

Oct 6, 1999

Appl. No.:

09/413044

Inventors:

Daniel R. Henderson - Palo Alto CA
Yu Chen - Sunnyvale CA
De Chao Yu - Foster City CA

Assignee:

Cell Genesys, Inc. - Foster City CA

International Classification:

G01N 3353

US Classification:

435 71, 4241401, 4242331, 4241311, 4241591, 4242781, 424 931, 530351, 514885

Abstract:

Methods of reducing pre-existing humoral immunity to a viral immunogenic therapeutic agent such as adenovirus, using immunoapheresis are disclosed. Antibodies specific for the viral immunogenic therapeutic agent are selectively removed from the blood of an individual prior to administration of the viral immunogenic therapeutic agent by reaction extracorporeally with an immunosorbent which specifically binds the antibody. After the antibody is selectively removed from the blood, the blood is reinfused into the patient and the viral immunogenic therapeutic agent is administered. The invention also provides kits and compositions for selective removal of anti-viral antibody.

US Patent:

6884327, Apr 26, 2005

Filed:

Mar 16, 2002

Appl. No.:

10/101492

Inventors:

Tao Pan - San Jose CA, US
Richard E. Demaray - Portola Valley CA, US
Yu Chen - San Jose CA, US
Yong Jin Xie - Cupertino CA, US
Rajiv Pethe - San Jose CA, US

International Classification:

C23C014/34

US Classification:

20419212, 4272481, 427259, 427282

Abstract:

A process for forming a mode size converter with an out-of-plane taper formed during deposition with a shadow mask is disclosed. Mode-size converters according to the present invention can have any number of configurations. Measured coupling efficiencies for waveguides with mode size converters according to the present invention show marked improvement.

US Patent:

6911200, Jun 28, 2005

Filed:

Mar 21, 2001

Appl. No.:

09/814357

Inventors:

Yu Chen - Cupertino CA, US
Daniel R. Henderson - Palo Alto CA, US

Assignee:

Cell Genesys, Inc. - Foster City CA

International Classification:

A01N063/00
A61K048/00
C12N015/861

US Classification:

424 932, 435455, 435456, 4353201

Abstract:

The invention provides methods of treating neoplasia using combinations of target cell-specific replication competent adenoviral vectors and chemotherapy, radiation therapy or combinations thereof. The adenoviral vectors are target cell-specific for the particular type of neoplasia for which treatment is necessary and the combination with the chemotherapy and/or radiation leads to synergistic treatment over existing adenoviral therapy or traditional chemotherapy and radiation therapy.

US Patent:

7276233, Oct 2, 2007

Filed:

Jun 27, 2005

Appl. No.:

11/166234

Inventors:

Yu Chen - Cupertino CA, US
Daniel R. Henderson - Palo Alto CA, US

Assignee:

Cell Genesys, Inc. - South San Francisco CA

International Classification:

A01N 63/00
A61K 48/00

US Classification:

424 932

Abstract:

The invention provides methods of treating neoplasia using combinations of target cell-specific replication competent adenoviral vectors and chemotherapy, radiation therapy or combinations thereof. The adenoviral vectors are target cell-specific for the particular type of neoplasia for which treatment is necessary and the combination with the chemotherapy and/or radiation leads to synergistic treatment over existing adenoviral therapy or traditional chemotherapy and radiation therapy.

US Patent:

7673143, Mar 2, 2010

Filed:

Feb 24, 2004

Appl. No.:

10/786345

Inventors:

William J. Yeager - Menlo Park CA, US
Yu Chen - San Jose CA, US
Brian K. Raymor - Arlington VA, US
Jackson Wong - Menlo Park CA, US

Assignee:

Sun Microsystems, Inc. - Menlo Park CA

International Classification:

H04L 9/32

US Classification:

713175, 713153, 713168

Abstract:

A method for securing a communication between a peer node and an intermediary peer node in a peer-to-peer network comprises the peer node generating a secured communication request to the intermediary peer node. The intermediary peer node authenticates the peer node in response to the secured communication request. The intermediary peer node issues a signed certificate of authority upon successful authentication.

US Patent:

7977240, Jul 12, 2011

Filed:

Feb 13, 2009

Appl. No.:

12/371239

Inventors:

Joerg Rockenberger - San Jose CA, US
Yu Chen - Pearland TX, US
Fabio Zürcher - Brisbane CA, US
Scott Haubrich - Albuquerque NM, US

Assignee:

Kovio, Inc. - Milpitas CA

International Classification:

H01L 21/44
H01L 21/4763

US Classification:

438674, 438622, 438637, 257E21273

Abstract:

Metal ink compositions, methods of forming such compositions, and methods of forming conductive layers are disclosed. The ink composition includes a bulk metal, a transition metal source, and an organic solvent. The transition metal source may be a transition metal capable of forming a silicide, in an amount providing from 0. 01 to 50 at. % of the transition metal relative to the bulk metal. Conductive structures may be made using such ink compositions by forming a silicon-containing layer on a substrate, printing a metal ink composition on the silicon-containing layer, and curing the composition. The metal inks of the present invention have high conductivity and form low resistivity contacts with silicon, and reduce the number of inks and printing steps needed to fabricate integrated circuits.

US Patent:

8495085, Jul 23, 2013

Filed:

Sep 27, 2010

Appl. No.:

12/891146

Inventors:

Mengchu Cai - San Jose CA, US
Yu Chen - San Jose CA, US
Eric Naoto Katayama - San Jose CA, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 17/30

US Classification:

707769, 707770

Abstract:

Methods and apparatus, including computer program products, implementing and using techniques for performing a partial update of a hierarchically structured document referencing one or more records stored in a database. An expression specifying one or more updates to be applied to the document is received. The document is searched to find update target position(s). Based on the received expression, a pending update list is built. When an update target position is found, a row of a document column in a base table is updated with the new version number for the document. New database records for insertion into the new document version are generated from the pending update list. Old database records to be replaced are identified. A database table for the document is updated to mark the old database records as obsolete and to add new database records to be referenced in the new version of the document.

US Patent:

8609864, Dec 17, 2013

Filed:

Jan 7, 2010

Appl. No.:

13/143155

Inventors:

Yu Chen - San Jose CA, US
Yi Chen - San Jose CA, US

Assignee:

Purdue Pharmaceutical Products, L.P. - Stamford CT

International Classification:

A61K 31/4184
C07D 235/16

US Classification:

5483097, 544311, 544317, 546 12, 556137, 556 40, 558 48, 558 81, 514394, 514110, 514507, 514517, 514 43, 536 2851, 562621, 562 43

Abstract:

The disclosure includes hydroxamic compounds of Formula I: (I) wherein P, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compounds.