Yu Ming Li

US Patent:

7838645, Nov 23, 2010

Filed:

May 2, 2005

Appl. No.:

11/119569

Inventors:

Eric H. Baehrecke - University Park MD, US
Ajjai Alva - Baltimore MD, US
Michael J. Lenardo - Potomac MD, US
Yu Li - Rockville MD, US

Assignee:

University of Maryland College Park - College Park MD
National Institutes of Health - Bethesda MD

International Classification:

C07H 21/02
C07K 16/00

US Classification:

536 231, 5303871

Abstract:

The present invention relates to a new molecular pathway in which activation of the receptor-interacting protein (RIP, a serine-threonine kinase) and Jun N-terminal kinase induce cell death with the morphology of autophagy. Further, autophagic death is induced by caspase 8 inhibition and expression of the mammalian genes ATG7 and beclin.

US Patent:

20120214155, Aug 23, 2012

Filed:

Nov 2, 2010

Appl. No.:

13/505719

Inventors:

Yu Li - Duluth GA, US
Inger K. Damon - Decatur GA, US
Hui Zhao - Lilburn GA, US

International Classification:

C12Q 1/70
C07H 21/04

US Classification:

435 5, 536 2432

Abstract:

This disclosure relates to compositions and methods of their use in detection and identification of a chordopoxvirus in a sample, such as diagnosis of an infection in a subject. The compositions and methods allow for detection and identification of all non-avian low-GC content chordopoxviruses, identification of most known high-GC content chordopoxvirus, and species-specific detection of Canarypox virus, Fowlpox virus, and Sealpox virus.