Yu Gui Li

US Patent:

6639666, Oct 28, 2003

Filed:

Nov 8, 2001

Appl. No.:

10/005712

Inventors:

Yu Li - Newton MA

Assignee:

Axsun Technologies, Inc. - Billerica MA

International Classification:

G01J 300

US Classification:

356300

Abstract:

A system and method for fast peak finding in an optical spectrum prioritizes the information it first generates and how the information is then forwarded from the system to a host computer, for example. A spectrum detection subsystem generates a spectrum of an optical signal. An analog-to-digital converter converts the spectrum into sample data. Finally, a data processing subsystem first detects the spectral locations of peaks in the spectrum using the sample data and then uploads the peak information to a host computer before performing processing to determine the shapes of the peaks and/or noise information for the optical signal, for example. The system is thus able to quickly find some information, such as whether or not channels or carriers are present, at what frequency the carriers are operating, and the carriers power level, and send this information to the host computer. In contrast, information concerning spectral shape or the noise floor is sent later in time.

US Patent:

7072041, Jul 4, 2006

Filed:

Jun 15, 2004

Appl. No.:

10/868319

Inventors:

Yu Li - Newton MA, US
Peter S. Whitney - Lexington MA, US
Jeffrey A. Korn - Lexington MA, US

Assignee:

Axsun Technologies, Inc. - Billerica MA

International Classification:

G01N 21/25

US Classification:

356416

Abstract:

A system and method for fast peak finding in an optical spectrum prioritizes the information it first generates and how the information is then forwarded from the system to a host computer, for example. A spectrum detection subsystem generates a spectrum of an optical signal. An analog-to-digital converter converts the spectrum into sample data. Finally, a data processing subsystem first detects the spectral locations of peaks in the spectrum using the sample data and then uploads the peak information to a host computer before performing processing to determine the shapes of the peaks and/or noise information for the optical signal, for example. The system is thus able to quickly find some information, such as whether or not channels or carriers are present, at what frequency the carriers are operating, and the carriers' power level, and send this information to the host computer. In contrast, information concerning spectral shape or the noise floor sent later in time.

US Patent:

7731964, Jun 8, 2010

Filed:

Oct 28, 2003

Appl. No.:

10/694874

Inventors:

Roberto Polakiewicz - Lexington MA, US
Jiong Wu - Reading MA, US
Yu Li - Andover MA, US

Assignee:

Cell Signaling Technology, Inc. - Danvers MA

International Classification:

A61K 39/00
A61K 39/395
C07K 16/00

US Classification:

4241391, 4241411, 5303879

Abstract:

The invention discloses newly-discovered phosphorylation sites in human IRS-1 and IRS-2, serine 1101 (Ser1101) and serine 1149 (Ser1149) respectively, and provides antibodies, both polyclonal and monoclonal, that selectively bind to IRS-1 and/or IRS-2 when phosphorylated at these respective sites, but do not bind to IRS-1 and/or IRS-2 when not phosphorylated at these respective sites. The sites are relevant to insulin-resistance in type 2 diabetes. Also provided are methods for determining the phosphorylation of IRS-1/2 or activity of PKC theta in a biological sample, by using a detectable reagent, such as the disclosed antibodies, that binds to IRS-1/2 only when phosphorylated at Ser1101/Ser1149. Kits comprising the phosphor-IRS-1/2 (Ser1101/1149) antibodies of the invention are also provided.

US Patent:

7807789, Oct 5, 2010

Filed:

Jun 21, 2007

Appl. No.:

11/821130

Inventors:

Ailan Guo - Burlington MA, US
Kimberly Lee - Seattle WA, US
Klarisa Rikova - Reading MA, US
Charles Farnsworth - Concord MA, US
Albrecht Moritz - Salem MA, US
Yu Li - Andover MA, US
Robert Polakiewicz - Lexington MA, US

Assignee:

Cell Signaling Technology, Inc. - Danvers MA

International Classification:

C12P 21/08
C07K 16/28

US Classification:

5303871, 5303881, 53038822, 5303891, 5303911, 5303913, 4241301, 4241411, 4241431, 4241781

Abstract:

The invention discloses 168 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of, and including, EGFR kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Calcium-Binding Proteins, Cell Cycle Regulation proteins, Cytoskeletal proteins, DNA Binding and Replication Proteins, GTPase Activating proteins, Guanine Nucleotide Exchange Factor proteins, Lipid Kinases, Receptor Tyrosine Kinases, Receptor Tyrosine Kinase ligands, Protein Kinases, Receptor and Protein Phosphatases, Transcription Factor proteins, Tumor Suppressor proteins, and Vesicle proteins.

US Patent:

7838645, Nov 23, 2010

Filed:

May 2, 2005

Appl. No.:

11/119569

Inventors:

Eric H. Baehrecke - University Park MD, US
Ajjai Alva - Baltimore MD, US
Michael J. Lenardo - Potomac MD, US
Yu Li - Rockville MD, US

Assignee:

University of Maryland College Park - College Park MD
National Institutes of Health - Bethesda MD

International Classification:

C07H 21/02
C07K 16/00

US Classification:

536 231, 5303871

Abstract:

The present invention relates to a new molecular pathway in which activation of the receptor-interacting protein (RIP, a serine-threonine kinase) and Jun N-terminal kinase induce cell death with the morphology of autophagy. Further, autophagic death is induced by caspase 8 inhibition and expression of the mammalian genes ATG7 and beclin.

US Patent:

8054466, Nov 8, 2011

Filed:

May 23, 2006

Appl. No.:

11/419993

Inventors:

Dale C. Flanders - Lexington MA, US
Yu Nathan Li - Lexington MA, US
Mark E. Kuznetsov - Lexington MA, US
Walid A. Atia - Lexington MA, US

Assignee:

Axsun Technologies, Inc. - Billerica MA

International Classification:

G01B 9/02

US Classification:

356451

Abstract:

A spectroscopy wavelength and amplitude referencing system comprises an optical bench receiving a tunable optical signal from a tunable signal source, a wavelength reference detector on the bench for determining a wavelength of the tunable optical signal, an amplitude reference detector on the bench for determining an amplitude of the tunable optical signal and an output optical signal fiber for transmitting the tunable optical signal to a sample. Also, spectroscopy system controller determines a spectral response of the sample to the tunable optical signal by determining an instantaneous wavelength of the tunable optical signal by reference to the wavelength reference detector.

US Patent:

20040042005, Mar 4, 2004

Filed:

Aug 20, 2003

Appl. No.:

10/644498

Inventors:

Yu Li - Newton MA, US

Assignee:

Axsun Technologies, Inc. - Billerica MA

International Classification:

G01J003/00

US Classification:

356/300000

Abstract:

A system and method for fast peak finding in an optical spectrum prioritizes the information it first generates and how the information is then forwarded from the system to a host computer, for example. A spectrum detection subsystem generates a spectrum of an optical signal. An analog-to-digital converter converts the spectrum into sample data. Finally, a data processing subsystem first detects the spectral locations of peaks in the spectrum using the sample data and then uploads the peak information to a host computer before performing processing to determine the shapes of the peaks and/or noise information for the optical signal, for example. The system is thus able to quickly find some information, such as whether or not channels or carriers are present, at what frequency the carriers are operating, and the carriers' power level, and send this information to the host computer. In contrast, information concerning spectral shape or the noise floor sent later in time.

US Patent:

20090061459, Mar 5, 2009

Filed:

Feb 29, 2008

Appl. No.:

12/074228

Inventors:

Roberto Polakiewicz - Lexington MA, US
Ailan Guo - Burlington MA, US
Albrecht Moritz - Salem MA, US
Klarisa Rikova - Reading MA, US
Kimberly Lee - Seattle WA, US
Erik Spek - Cambridge MA, US
Yu Li - Andover MA, US
Charles Farnsworth - Concord MA, US

International Classification:

G01N 33/53
C07K 16/18
C07K 14/00
C12N 5/18

US Classification:

435 78, 436536, 5303877, 530402, 435346

Abstract:

The invention discloses nearly 443 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Protein kinases (including Serine/Threonine dual specificity, and Tyrosine kinases), Adaptor/Scaffold proteins, Transcription factors, Phospoatases, Tumor supressors, Ubiquitin conjugating system proteins, Translation initiation complex proteins, RNA binding proteins, Apoptosis proteins, Adhesion proteins, G protein regulators/GTPase activating protein/Guanine nucleotide exchange factor proteins, and DNA binding/replication/repair proteins, as well as other protein types.