Yuan Cheng

US Patent:

6384244, May 7, 2002

Filed:

May 11, 2001

Appl. No.:

09/853796

Inventors:

Ian Davies - Princeton NJ
Karl Hansen - Atlantic Highlands NJ
Paul N. Devine - Lincroft NJ
Louis Matty, Jr. - Hillsborough NJ
Yuan Cheng - Edison NJ
Philippe M. Rabbat - Baie dUrfe, CA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D31104

US Classification:

549399

Abstract:

cis-aminochromanols are obtained in high yield and with high selectivity over their trans counterparts by hydrogenating the corresponding oximes in the presence of a catalyst and an acid selected from HBr, HCl, and organic sulfonic acid. The cis-aminochromanols can be employed as intermediates in the production of HIV protease inhibitors which are useful for treating HIV infection and AIDS.

US Patent:

6642237, Nov 4, 2003

Filed:

Nov 21, 2000

Appl. No.:

09/718223

Inventors:

James R. Tata - Westfield NJ
Kevin T. Chapman - Scotch Plains NJ
Joseph Leslie Duffy - Cranford NJ
Nancy J. Kevin - East Brunswick NJ
Yuan Cheng - Edison NJ
Thomas A. Rano - Somerville NJ
Fengqi Zhang - Edison NJ
Tracy Huening - Madison NJ
Brian Anthony Kirk - Basking Ridge NJ
Zhijian Lu - Clinton NJ
Subharekha Raghavan - Teaneck NJ
Fred J. Fleitz - Franklin Park NJ
Daniel E. Petrillo - Hoboken NJ
Richard J. Varsolona - Scotch Plains NJ
David Askin - Warren NJ
R. Scott Hoerrner - Westfield NJ
Robert Purick - Edison NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D491048

US Classification:

51425202, 544362, 544376, 544364, 544295, 51425304, 51425311, 51425301, 514252

Abstract:

-Hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamide compounds are inhibitors of HIV protease and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. These compounds are effective against HIV viral mutants which are resistant to HIV protease inhibitors currently used for treating AIDS and HIV infection.

US Patent:

6993185, Jan 31, 2006

Filed:

Aug 30, 2002

Appl. No.:

10/231670

Inventors:

Jinhong Katherine Guo - West Windsor NJ, US
Yuan Cheng - Piscataway NJ, US

Assignee:

Matsushita Electric Industrial Co., Ltd. - Osaka

International Classification:

G06K 9/34
G06K 9/00

US Classification:

382176, 382164

Abstract:

A method for segmenting a color document into regions of text and halftone discriminates between text and halftone by examining the texture of the document. A color document is digitized, and a color space transform is preferably applied to the digitized document. The texture of the document is identified and a noise reduction step is preferably applied. Bounding boxes (blocks) within the document are identified and then the areas within the bounding boxes are classified as either text or halftone. Two alternative methods are described for examining the document texture. In the first method, a windowing operation is applied to either an intensity image or a color difference image. In the second method, a wavelet transform step combined with Fuzzy K-Mean clustering is applied. Bounding boxes are classified as either text or halftone based upon the relative periodicity of a horizontal or vertical (or both) histogram of each bounding box.

US Patent:

7125865, Oct 24, 2006

Filed:

Jul 21, 2003

Appl. No.:

10/522114

Inventors:

A. Brian Jones - Walden, GB
Alan D. Adams - Cranford NJ, US
Ahren I. Green - Green Brook NJ, US
Shaei Y. Huang - Jeffersonville PA, US
Bruno Tse - Philadelphia PA, US
Clare E. Gutteridge - Annapolis MD, US
Yuan Cheng - Newbury Park CA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 277/04
C07D 277/12
C07D 261/20
C07D 421/00
C07D 241/00

US Classification:

51421208, 5142308, 514241, 51425402, 51425505, 514256, 514269, 514274, 514338, 514369, 514379, 540524, 544137, 544220, 544310, 544331, 544368, 544405, 5462721, 548183, 548241

Abstract:

The present invention relates to novel LXR ligands of Formula I and the pharmaceutically acceptable salts, esters and tautomers thereof, which are useful in the treatment of dyslipidemic conditions, particularly depressed levels of HDL cholesterol.

US Patent:

7435823, Oct 14, 2008

Filed:

Jan 24, 2005

Appl. No.:

11/042634

Inventors:

Michele Potashman - Cambridge MA, US
Steven Bellon - Wellesley MA, US
Shon Booker - Thousand Oaks CA, US
Yuan Cheng - Newbury Park CA, US
Joseph L. Kim - Wayland MA, US
Andrew Tasker - Simi Valley CA, US
Ning Xi - Thousand Oaks CA, US
Shimin Xu - Ventura CA, US
Jean-Christophe Harmange - Andover MA, US
George Borg - Cambridge MA, US
Matthew Weiss - Boston MA, US
Brian L. Hodous - Cambridge MA, US
Russell Graceffa - Hampton NH, US
William H. Buckner - Arlington MA, US
Craig E. Masse - Cambridge MA, US
Deborah Choquette - Medford MA, US
Matthew W. Martin - Cambridge MA, US
Julie Germain - Medford MA, US
Lucian V. DiPietro - Gloucester MA, US
Stuart C. Chaffee - Cambridge MA, US
Joseph J. Nunes - Andover MA, US
John L. Buchanan - Brookline MA, US
Gregory J. Habgood - Merrimac MA, US
David C. McGowan - Woluwe St. Pierre, BE
Douglas A. Whittington - Waltham MA, US
Daniel La - Brookline MA, US
Vinod F. Patel - Acton MA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 215/38
C07D 265/34

US Classification:

546153, 546 15, 544 99, 544105

Abstract:

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

7626030, Dec 1, 2009

Filed:

Jan 24, 2005

Appl. No.:

11/042398

Inventors:

Jean-Christophe Harmange - Andover MA, US
David Bauer - Sudbury MA, US
Shon Booker - Thousand Oaks CA, US
Yuan Cheng - Newbury Park CA, US
Shimin Xu - Santa Barbara CA, US
Ning Xi - Thousand Oaks CA, US
Joseph L. Kim - Wayland MA, US
Andrew Tasker - Simi Valley CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 215/38

US Classification:

546157, 546153

Abstract:

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

7652009, Jan 26, 2010

Filed:

Nov 29, 2005

Appl. No.:

11/289659

Inventors:

Steven Bellon - Wellesley MA, US
Shon Booker - Thousand Oaks CA, US
Noel D'Angelo - Thousand Oaks CA, US
Celia Dominguez - Los Angeles CA, US
Ingrid Fellows - Fresno CA, US
Matthew Lee - Calabasas CA, US
Longbin Liu - Thousand Oaks CA, US
Elizabeth Rainbeau - Port Hueneme CA, US
Aaron C. Siegmund - Ventura CA, US
Andrew Tasker - Simi Valley CA, US
Ning Xi - Thousand Oaks CA, US
Yuan Cheng - Newbury Park CA, US

Assignee:

Amgem Inc. - Thousand Oaks CA

International Classification:

A61K 31/506
C07D 401/02
C07D 239/22

US Classification:

51425204, 514269, 544238, 544242, 544298, 544319

Abstract:

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

7765295, Jul 27, 2010

Filed:

Oct 24, 2007

Appl. No.:

11/877804

Inventors:

Paul Anastas - Needham MA, US
William Ryan Breen - Melrose MA, US
Yuan Cheng - Needham MA, US
Allen Lieberman - Natick MA, US
Imad Mouline - Braintree MA, US

Assignee:

Compuware Corporation - Detroit MI

International Classification:

G06F 15/173
G06F 15/177
G06F 9/44
G06F 9/46
G06F 15/16
G06F 3/00
G06F 13/00

US Classification:

709224, 715736, 715745

Abstract:

A system monitors browser operation on a web page to identify objects referenced by the web page. For objects referenced by the web page, the system tracks a performance metric associated with each object. The system performs post-processing on the performance metrics of objects referenced by the web page to create a performance record for that web page, and transfers the performance record to a remote server for analysis of performance of web page operation in the browser.