Yuan M Lu

US Patent:

20140065200, Mar 6, 2014

Filed:

Aug 27, 2013

Appl. No.:

14/011488

Inventors:

Yuan Lu - Chapel Hill NC, US

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

C07F 7/08

US Classification:

424443, 428398, 556424, 556418, 424718

Abstract:

In one aspect, the subject matter disclosed herein is directed to NO-releasing functionalized nanorods having a desirable aspect ratio. The nanorods are also capable of releasing a desirable amount of NO (nitric oxide). In another aspect, the subject matter disclosed herein is directed to a composition comprising the NO-releasing nanorods. In another aspect, the subject matter disclosed herein is directed to methods of preparing NO-releasing nanorods having a specified aspect ratio. In another aspect, the subject matter disclosed herein is directed to a method of combating infection comprising administering to a subject a composition comprising NO-releasing nanorods, wherein the nanorods have a specified aspect ratio and NO-release profile.

US Patent:

20210380755, Dec 9, 2021

Filed:

Oct 29, 2019

Appl. No.:

17/287350

Inventors:

- Romeo MI, US
Michael Czaplicki - Romeo MI, US
Yuan Lu - Romeo MI, US

International Classification:

C08G 59/18
C08G 59/24
C08K 5/18
C08G 85/00

Abstract:

A material comprising an epoxy/elastomer adduct, a polymeric particle, from about 0.05 to about 20 weight percent of an epoxy/diacid adduct, and optionally, an amine reaction product.

US Patent:

20210324227, Oct 21, 2021

Filed:

Sep 19, 2017

Appl. No.:

16/334501

Inventors:

- Romeo MI, US
Michael Czaplicki - Romeo MI, US
Ken Mazich - Romeo MI, US
Yuan LU - Romeo MI, US
Kevin Hicks - Romeo MI, US
Austin O'Connor - Romeo MI, US

International Classification:

C09D 171/00
C04B 41/48

Abstract:

The present teachings contemplate a method for sealing comprising providing a substrate that includes a plurality of pores, locating a polymerizable composition onto a surface of the substrate, the polymerizable composition including a monofunctional, difunctional or multifunctional methylene malonate or a cyanoacrylate, and initiating polymerization of the composition, wherein polymerization is initiated by the use of an initiator or by the presence of a latent activating agent.

US Patent:

20200354480, Nov 12, 2020

Filed:

Jul 23, 2020

Appl. No.:

16/937246

Inventors:

- Chapel Hill NC, US
Yuan Lu - Chapel Hill NC, US

International Classification:

C08B 37/08
C08B 37/00
A61K 47/60
C08L 5/08

Abstract:

The presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides, in particular, polyglucosamines, and their use in biomedical and pharmaceutical applications. More particularly, in some embodiments, the presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides that release nitric oxide in a controlled and targeted manner, thereby prolonging the therapeutic effects of nitric oxide and improving the specificity of nitric oxide delivery to targeted cells and/or tissues.

US Patent:

20190225747, Jul 25, 2019

Filed:

Oct 5, 2017

Appl. No.:

16/339299

Inventors:

- Chapel Hill NC, US
Lei Yang - Carrboro NC, US
Yuan Lu - Troy MI, US

International Classification:

C08G 63/91
C08G 83/00
A61K 47/59
A61K 33/00

Abstract:

The invention generally relates to compositions comprising degradable polymers and methods of making degradable polymers. Specifically, the disclosed degradable polymers comprise a biodegradable polymer backbone, a nitric oxide linker moiety, and a nitric oxide molecule. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

US Patent:

20190203075, Jul 4, 2019

Filed:

Sep 19, 2017

Appl. No.:

16/332818

Inventors:

- Romeo MI, US
Ken Mazich - Romeo MI, US
Yuan Lu - Romeo MI, US
Kevin Hicks - Romeo MI, US
Austin O'Connor - Romeo MI, US
Jason Walker - Romeo MI, US

International Classification:

C09J 5/04
C09J 5/06
C09J 135/02
C09J 135/04
C08J 5/12

Abstract:

The present teachings contemplate a method comprising providing a first and second substrate, locating an initiator onto a surface of the first or second substrate, the initiator including a substance for initiating polymerization of a polymerizable adhesive, locating the polymerizable adhesive onto a surface of the first and second substrate, the adhesive including a monofunctional, difunctional, or multifunctional methylene malonate, or cyanoacrylate, and contacting first and second substrate.

US Patent:

20180162956, Jun 14, 2018

Filed:

Dec 8, 2017

Appl. No.:

15/836121

Inventors:

- Chapel Hill NC, US
Yuan Lu - Chapel Hill NC, US

International Classification:

C08B 37/08
A61K 47/60
C08L 5/08
C08B 37/00

Abstract:

The presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides, in particular, polyglucosamines, and their use in biomedical and pharmaceutical applications. More particularly, in some embodiments, the presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides that release nitric oxide in a controlled and targeted manner, thereby prolonging the therapeutic effects of nitric oxide and improving the specificity of nitric oxide delivery to targeted cells and/or tissues.

US Patent:

20180010014, Jan 11, 2018

Filed:

Jul 11, 2017

Appl. No.:

15/646843

Inventors:

- Romeo MI, US
Michael J. Czaplicki - Rochester MI, US
Kevin Hicks - Harrison Township MI, US
Austin O'Connor - Washington MI, US
Yuan Lu - Troy MI, US

International Classification:

C09J 5/06
B05D 1/28
F16L 9/127
B05D 1/02
B05D 1/18
F16L 13/10
C09J 135/04

Abstract:

The present teachings contemplate a method comprising coating a poly(vinyl chloride) material with a composition including a dicarbonyl compound, a cyanoacrylate compound, or a combination thereof and a viscosity modifying agent so that the composition has a viscosity of from about 50 cps to about 2500 cps; wherein the coated poly(vinyl chloride) material is capable of adhering to a second material without the use of a primer.