Yuan Xiao Y Lu

US Patent:

20140065200, Mar 6, 2014

Filed:

Aug 27, 2013

Appl. No.:

14/011488

Inventors:

Yuan Lu - Chapel Hill NC, US

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

C07F 7/08

US Classification:

424443, 428398, 556424, 556418, 424718

Abstract:

In one aspect, the subject matter disclosed herein is directed to NO-releasing functionalized nanorods having a desirable aspect ratio. The nanorods are also capable of releasing a desirable amount of NO (nitric oxide). In another aspect, the subject matter disclosed herein is directed to a composition comprising the NO-releasing nanorods. In another aspect, the subject matter disclosed herein is directed to methods of preparing NO-releasing nanorods having a specified aspect ratio. In another aspect, the subject matter disclosed herein is directed to a method of combating infection comprising administering to a subject a composition comprising NO-releasing nanorods, wherein the nanorods have a specified aspect ratio and NO-release profile.

US Patent:

20200354480, Nov 12, 2020

Filed:

Jul 23, 2020

Appl. No.:

16/937246

Inventors:

- Chapel Hill NC, US
Yuan Lu - Chapel Hill NC, US

International Classification:

C08B 37/08
C08B 37/00
A61K 47/60
C08L 5/08

Abstract:

The presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides, in particular, polyglucosamines, and their use in biomedical and pharmaceutical applications. More particularly, in some embodiments, the presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides that release nitric oxide in a controlled and targeted manner, thereby prolonging the therapeutic effects of nitric oxide and improving the specificity of nitric oxide delivery to targeted cells and/or tissues.

US Patent:

20190225747, Jul 25, 2019

Filed:

Oct 5, 2017

Appl. No.:

16/339299

Inventors:

- Chapel Hill NC, US
Lei Yang - Carrboro NC, US
Yuan Lu - Troy MI, US

International Classification:

C08G 63/91
C08G 83/00
A61K 47/59
A61K 33/00

Abstract:

The invention generally relates to compositions comprising degradable polymers and methods of making degradable polymers. Specifically, the disclosed degradable polymers comprise a biodegradable polymer backbone, a nitric oxide linker moiety, and a nitric oxide molecule. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

US Patent:

20180162956, Jun 14, 2018

Filed:

Dec 8, 2017

Appl. No.:

15/836121

Inventors:

- Chapel Hill NC, US
Yuan Lu - Chapel Hill NC, US

International Classification:

C08B 37/08
A61K 47/60
C08L 5/08
C08B 37/00

Abstract:

The presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides, in particular, polyglucosamines, and their use in biomedical and pharmaceutical applications. More particularly, in some embodiments, the presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides that release nitric oxide in a controlled and targeted manner, thereby prolonging the therapeutic effects of nitric oxide and improving the specificity of nitric oxide delivery to targeted cells and/or tissues.

US Patent:

20150225488, Aug 13, 2015

Filed:

Aug 16, 2013

Appl. No.:

14/421525

Inventors:

- Chapel Hill NC, US
Yuan Lu - Chapel Hill NC, US

International Classification:

C08B 37/08
A61K 47/48

Abstract:

The presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides, in particular, polyglucosamines, and their use in biomedical and pharmaceutical applications. More particularly, in some embodiments, the presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides that release nitric oxide in a controlled and targeted manner, thereby prolonging the therapeutic effects of nitric oxide and improving the specificity of nitric oxide delivery to targeted cells and/or tissues.