Yuk F Cheung

US Patent:

8613776, Dec 24, 2013

Filed:

Dec 29, 2008

Appl. No.:

12/810468

Inventors:

Yuk Kee Cheung - New York NY, US
Samuel K. Sia - New York NY, US
Curtis D. Chin - New York NY, US
Brian Michael Gillette - Bronx NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61F 2/02

US Classification:

623 2372

Abstract:

An extracellular matrix (ECM)-based scaffold suitable for artificial skin as well as other structures can be formed using a bioreactor fabricated with a pattern that introduces desired structural features, on the microscale and/or nanoscale, to ECM-precursors gelled in the bioreactor. The bioreactor can produce a finely patterned scaffold—over clinically relevant size scales—sufficiently robust for routine handling. Preformed ECM-based scaffolds can also have microscale and/or nano-scale structural features introduced into a surface thereof. ECM-based scaffolds may be formed with well-defined structural features via microetching and/or remodeling via ‘contact degradation. ’ A surface-activated pattern can be used to degrade the ECM-based scaffold at contact regions between the pattern and the ECM. The produced ECM-based scaffolds can have structures of dimensions conducive to host tissue ingrowth while preserving the fibrous structure and ligand density of natural ECMs.

US Patent:

20110243790, Oct 6, 2011

Filed:

Jun 30, 2008

Appl. No.:

12/594176

Inventors:

Yuk Kee Cheung - New York NY, US
Samuel K. Sia - New York NY, US
Curtis D. Chin - New York NY, US
Neha Agarwal - Los Altos Hills CA, US

Assignee:

The Trustees of Columbia University - New York NY

International Classification:

G01N 21/76
G01N 33/48
G01N 21/75

US Classification:

422 52, 422 681, 422 8205

Abstract:

A particle counter for analyzing blood has features which provide for automatic operation and preferably, also provide for portable use in a low resource setting. In a preferred embodiment, preferred embodiment, the device is used to obtain CD4 counts for AIDS diagnosis.

US Patent:

20130030354, Jan 31, 2013

Filed:

Jul 27, 2012

Appl. No.:

13/560905

Inventors:

Sau Yin CHIN - Bronx NY, US
Samuel K. Sia - New York NY, US
Olga Ordeig - Brooklyn NY, US
Anne-Celine Kohler - Paris, FR
Yuk Kee Cheung - Cambridge MA, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61M 37/00
A61M 5/168

US Classification:

604 20, 604 22, 604131, 604500

Abstract:

MicroElectroMechanical System (MEMS) devices can be fabricated completely of hydrogel materials. Such hydrogels can include polyethylene glycol with diacrylate functional groups (e.g., PEGDA), which are photopolymerizable in the presence of crosslinkers and photoinitiators. By using PEGDA monomers of different molecular weights and at different percentages, the mechanical properties of the polymerized gels and their respective permeabilities can be tuned. This spatial variation in properties and permeabilities can lead to different functionalities between different portions of the hydrogel MEMS device. Portions of the hydrogel device may be remotely actuated by applying wave energy, for example, a magnetic field, high intensity focused ultrasound, and/or infrared radiation. The remote actuation can allow the device to be actuated in vivo, for example, to allow the device to deliver a drug or other substance at a desired time and/or desired location within a patient.

US Patent:

20130048092, Feb 28, 2013

Filed:

Jan 28, 2011

Appl. No.:

13/575942

Inventors:

Kweku Addae-Mensah - Hackensack NJ, US
Yuk Kee Cheung - New York NY, US
Samuel K. Sia - New York NY, US

Assignee:

The Trustee of Columbia University in the City of New York - New York NY

International Classification:

F17D 3/00
H05K 13/00
B01L 3/00

US Classification:

137 2, 422505, 295921

Abstract:

Microfabricated microvalves may be used with liquid-filled control channels and actuated using compact and battery-powered components, without the need for heavier or fixed infrastructure. The disclosed embodiments include microvalves with on-off fluid control with relatively fast response times, coordinated switching of multiple valves, and operation of a biological (enzyme-substrate) assay in a handheld configuration.

US Patent:

20140031750, Jan 30, 2014

Filed:

Jul 29, 2013

Appl. No.:

13/953700

Inventors:

SAMUEL K. SIA - New York NY, US
SAU YIN CHIN - Bronx NY, US
ANNE-CELINE KOHLER - Paris, FR
YUK KEE CHEUNG POH - Cambridge MA, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61M 5/168

US Classification:

604131

Abstract:

MicroElectroMechanical System (MEMS) devices can be fabricated completely of hydrogel materials. Such hydrogels can include polyethylene glycol with diacrylate functional groups (e.g., PEGDA), which are photopolymerizable in the presence of crosslinkers and photoinitiators. By using PEGDA monomers of different molecular weights and at different percentages, the mechanical properties of the polymerized gels and their respective permeabilities can be tuned. This spatial variation in properties and permeabilities can lead to different functionalities between different portions of the hydrogel MEMS device. Portions of the hydrogel device may be remotely actuated by applying wave energy, for example, a magnetic field, high intensity focused ultrasound, and/or infrared radiation. The remote actuation can allow the device to be actuated in vivo, for example, to allow the device to deliver a drug or other substance at a desired time and/or desired location within a patient.

US Patent:

20180256816, Sep 13, 2018

Filed:

Jan 16, 2018

Appl. No.:

15/872649

Inventors:

- New York NY, US
Sau Yin CHIN - Bronx NY, US
Anne-Celine KOHLER - Paris, FR
Yuk Kee Cheung POH - Cambridge MA, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61M 5/168
A61M 5/142
A61K 9/00
B82Y 5/00

Abstract:

MicroElectroMechanical System (MEMS) devices can be fabricated completely of hydrogel materials. Such hydrogels can include polyethylene glycol with diacrylate functional groups (e.g., PEGDA), which are photopolymerizable in the presence of crosslinkers and photoinitiators. By using PEGDA monomers of different molecular weights and at different percentages, the mechanical properties of the polymerized gels and their respective permeabilities can be tuned. This spatial variation in properties and permeabilities can lead to different functionalities between different portions of the hydrogel MEMS device. Portions of the hydrogel device may be remotely actuated by applying wave energy, for example, a magnetic field, high intensity focused ultrasound, and/or infrared radiation. The remote actuation can allow the device to be actuated in vivo, for example, to allow the device to deliver a drug or other substance at a desired time and/or desired location within a patient.

US Patent:

20140333453, Nov 13, 2014

Filed:

Jul 23, 2014

Appl. No.:

14/339069

Inventors:

- New York NY, US
Mario Matteo MODENA - Cirie, IT
Paolo CADINU - Nuoro, IT
Keith YEAGER - Jersey City NJ, US
Yuk Kee Cheung POH - Cambridge MA, US
Robert HOUGHTALING - Kennett Square PA, US
Curtis D. CHIN - San Diego CA, US

International Classification:

G06F 19/00

US Classification:

34087007

Abstract:

A portable unitary device handheld diagnostic device can be operated with minimal power requirement and provides ease of operation as well as low cost communication of diagnostic data from remote locations. The device can provide nucleic-acid based diagnostics with minimal training, little to no sample preparation, and generates diagnostic data in about 45 minutes. A system can enable point of care transmission from any location globally using a low cost satellite-based data link technique, for example, Short Burst Data (SBD), combined with data encoding.