Yumiko Sakurai

US Patent:

20130149214, Jun 13, 2013

Filed:

Dec 11, 2012

Appl. No.:

13/710707

Inventors:

Emory University - Atlanta GA, US
Children's Healthcare of Atlanta, Inc. - Atlanta GA, US
Georgia Tech Research Corporation - Atlanta GA, US
David R. Myers - Atlanta GA, US
Yumiko Sakurai - Atlanta GA, US
Byungwook Ahn - Atlanta GA, US
Yongzhi Qiu - Atlanta GA, US
Gang Bao - Atlanta GA, US

Assignee:

EMORY UNIVERSITY - Atlanta GA
GEORGIA TECH RESEARCH CORPORATION - Atlanta GA
CHILDREN'S HEALTHCARE OF ATLANTA, INC. - Atlanta GA

International Classification:

B01L 3/00

US Classification:

422502

Abstract:

Microfluidic devices and processes are provided that relate to microvascular-sized systems configured to identify specific pathophysiological characteristics related to the interactions between, for example, blood cells and endothelial cells combined with geometric and flow constraints of microvasculature. The device may include at least one layer, the layer including a plurality of microvascularized-sized fluidic channels, the plurality of microfluidic channels being disposed in a geometric pattern. The layer may be composed of a hydrogel and/or a silicon elastomer. The channels may include subchannels of different lengths.