Yuri Francis Mckee

US Patent:

20110129516, Jun 2, 2011

Filed:

Oct 29, 2010

Appl. No.:

12/916398

Inventors:

Jean Theresa JACOB - New Orleans LA, US
Kevin John Halloran - Somerset NJ, US
Yuri McKee - Atlanta GA, US

International Classification:

A61K 9/00
A61K 38/14
A61K 38/13
A61K 31/216
A61K 31/138
A61K 31/7036
A61P 27/02
A61P 27/04
A61P 31/00
A61P 31/04
B05D 3/10

US Classification:

424427, 514 208, 514 205, 514530, 514652, 514 40, 427 215

Abstract:

A method of forming an ocular delivery device includes exposing a solid, shaped cellulose polymer to a solution including an active pharmaceutical ingredient (API) and a solvent capable of solubilizing the API, wherein the polymer absorbs at least a portion of the solution, including the API and solvent. The method may further include removing at least a portion of the absorbed solvent from the polymer by allowing the absorbed solvent to evaporate from the polymer or by drying the polymer. A variety of cellulose polymers may be used, including hydroxypropyl cellulose. A variety of APIs may be used, including Cyclosporine, Tobramycin and Vancomycin. Ocular delivery devices prepared by the methods may be used to treat a variety of eye disorders.

US Patent:

20140187497, Jul 3, 2014

Filed:

Nov 22, 2013

Appl. No.:

14/087864

Inventors:

- Baton Rouge LA, US
- Hamilton, BM
Yuri MCKEE - Atlanta GA, US

Assignee:

Louisiana State University Agricultural and Mechanical College - Baton Rouge LA
ATON PHARMA, INC. - Hamilton

International Classification:

A61K 9/00
A61K 31/7036
A61K 31/216
A61K 31/133
A61K 38/12
A61K 38/13

US Classification:

514 205, 514 208, 514530, 514646, 514 40, 427 221

Abstract:

A method of forming an ocular delivery device includes exposing a solid, shaped cellulose polymer to a solution including an active pharmaceutical ingredient (API) and a solvent capable of solubilizing the API, wherein the polymer absorbs at least a portion of the solution, including the API and solvent. The method may further include removing at least a portion of the absorbed solvent from the polymer by allowing the absorbed solvent to evaporate from the polymer or by drying the polymer. A variety of cellulose polymers may be used, including hydroxypropyl cellulose. A variety of APIs may be used, including Cyclosporine, Tobramycin and Vancomycin. Ocular delivery devices prepared by the methods may be used to treat a variety of eye disorders.