Zhaolin Z Wang

US Patent:

8008088, Aug 30, 2011

Filed:

Jun 26, 2006

Appl. No.:

11/475784

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Masimo Laboratories, Inc. - Irvine CA

International Classification:

G01N 33/00
A61K 49/00

US Classification:

436 95, 436172, 436164, 436518, 436546, 424 96, 424 91

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

8029765, Oct 4, 2011

Filed:

Dec 23, 2004

Appl. No.:

10/584821

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Masimo Laboratories, Inc. - Irvine CA

International Classification:

A61K 49/00

US Classification:

424 91

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

8466286, Jun 18, 2013

Filed:

Aug 22, 2011

Appl. No.:

13/215061

Inventors:

Emile M. Bellott - Beverly MA, US
Dongsheng Bu - Piscataway NJ, US
James J. Childs - Bolton MA, US
Christopher Lambert - Hudson MA, US
Hubert A. Nienaber - Newburyport MA, US
Shirley J. Shi - Lexington MA, US
Zhaolin Wang - Wellesley MA, US
Jerome J. Workman - Madison WI, US
Alex R. Zelenchuk - Stoughton MA, US

Assignee:

Cercacor Laboratories, Inc. - Irvine CA

International Classification:

C07F 5/02
A61K 49/00
A61B 5/00
A61B 8/00
A61B 10/00
C07D 471/00

US Classification:

546 13, 546 66, 514288, 514 64, 436 95, 436172, 436164, 424 91, 424 96

Abstract:

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

US Patent:

20030096763, May 22, 2003

Filed:

Jul 27, 2001

Appl. No.:

09/917107

Inventors:

Yat Or - Cambridge MA, US
Ly Phan - Malden MA, US
Zhaolin Wang - Wellesley MA, US
Tianying Jian - Boston MA, US

Assignee:

Enanta Pharmaceuticals, Inc.

International Classification:

A61K031/7048
C07H017/08
A61K031/7052

US Classification:

514/028000, 536/007100

Abstract:

There are described novel 4′substituted 16-membered macrolides and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds

US Patent:

20210283212, Sep 16, 2021

Filed:

Jan 7, 2021

Appl. No.:

17/143232

Inventors:

- Cambridge MA, US
Ketki Ashok Dhamnaskar - Foster City CA, US
Daniel Elbaum - Newton MA, US
Kristopher Josephson - San Carlos CA, US
Kelley Cronin Larson - Quincy MA, US
Zhong Ma - Lexington MA, US
Nathan Ezekiel Nims - Winchester MA, US
Alonso Ricardo - Winchester MA, US
Kathleen Seyb - Wakefield MA, US
Guo-Qing Tang - Acton MA, US
Douglas A. Treco - Arlington MA, US
Zhaolin Wang - Wellesley MA, US
Ping Ye - Lexington MA, US
Hong Zheng - New York NY, US
Sarah Jacqueline Perlmutter - Urbana IL, US

International Classification:

A61K 38/10
A61K 39/00
C07K 16/36

Abstract:

The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.

US Patent:

20210246167, Aug 12, 2021

Filed:

Apr 21, 2021

Appl. No.:

17/236247

Inventors:

- Cambridge MA, US
Ketki Ashok Dhamnaskar - Foster City CA, US
Daniel Elbaum - Newton MA, US
Kristopher Josephson - San Carlos CA, US
Kelley Cronin Larson - Quincy MA, US
Zhong Ma - Lexington MA, US
Nathan Ezekiel Nims - Winchester MA, US
Alonso Ricardo - Winchester MA, US
Kathleen Seyb - Wakefield MA, US
Guo-Qing Tang - Acton MA, US
Douglas A. Treco - Arlington MA, US
Zhaolin Wang - Wellesley MA, US
Ping Ye - Lexington MA, US
Hong Zheng - New York NY, US
Sarah Jacqueline Perlmutter - Urbana IL, US
Robert Paul Hammer - Maynard MA, US

International Classification:

C07K 7/08
A61K 47/64
C07K 7/06
C07K 16/00

Abstract:

The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.

US Patent:

20200155639, May 21, 2020

Filed:

Jan 30, 2020

Appl. No.:

16/776551

Inventors:

- Cambridge MA, US
Ketki Ashok Dhamnaskar - Foster City CA, US
Daniel Elbaum - Newton MA, US
Kristopher Josephson - San Carlos CA, US
Kelley Cronin Larson - Quincy MA, US
Zhong Ma - Lexington MA, US
Nathan Ezekiel Nims - Winchester MA, US
Alonso Ricardo - Winchester MA, US
Kathleen Seyb - Wakefield MA, US
Guo-Qing Tang - Acton MA, US
Douglas A. Treco - Arlington MA, US
Zhaolin Wang - Wellesley MA, US
Ping Ye - Lexington MA, US
Hong Zheng - New York NY, US
Sarah Jacqueline Perlmutter - Urbana IL, US

International Classification:

A61K 38/10
C07K 16/36
A61K 39/00

Abstract:

The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.

US Patent:

20200123202, Apr 23, 2020

Filed:

Jan 2, 2020

Appl. No.:

16/732502

Inventors:

- Cambridge MA, US
Ketki Ashok Dhamnaskar - Cambridge MA, US
Daniel Elbaum - Newton MA, US
Kristopher Josephson - San Carlos CA, US
Kelley Cronin Larson - Quincy MA, US
Zhong Ma - Lexington MA, US
Nathan Ezekiel Nims - Winchester MA, US
Alonso Ricardo - Winchester MA, US
Kathleen Seyb - Wakefield MA, US
Guo-Qing Tang - Acton MA, US
Douglas A. Treco - Arlington MA, US
Zhaolin Wang - Wellesley MA, US
Ping Ye - Lexington MA, US
Hong Zheng - New York NY, US
Sarah Jacqueline Perlmutter - Urbana IL, US
Robert Paul Hammer - Maynard MA, US

International Classification:

C07K 7/08
A61K 47/64
C07K 16/00
C07K 7/06

Abstract:

The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.