Zhen Hao Li

US Patent:

20110129020, Jun 2, 2011

Filed:

Aug 8, 2008

Appl. No.:

12/737662

Inventors:

Zhen Li - Burbank CA, US
Adeel Abbas - Plainsboro NJ, US
Xiaoan Lu - Princeton NJ, US
Cristin Gomila - Princeton NJ, US

International Classification:

H04N 7/12

US Classification:

37524029, 375E0719

Abstract:

A method and apparatus for detecting banding artifacts in digital images and video contents. The method operates to (i) find the locations of the banding artifacts, (ii) determine the strength of the banding artifact per block, and (iii) determine overall banding artifact strength per picture. The banding artifact detection and strength assignment is done by first finding areas that are prone to banding artifact and then considering the local characteristics of the area to reduce the false detection. The banding artifact strength of a picture is determined by considering the size and the strength of the artifact areas in this picture as well as the artifact strength in the neighboring pictures.

US Patent:

20110135012, Jun 9, 2011

Filed:

Aug 8, 2008

Appl. No.:

12/737661

Inventors:

Zhen Li - Burbank CA, US
Adeel Abbas - Plainsboro NJ, US
Xiaoan Lu - Princetyon NJ, US
Cristina Gomila - Princeton NJ, US

International Classification:

H04N 11/02

US Classification:

37524029, 375E07026

Abstract:

The present invention involves detecting dark noise artifacts in coded images and video. Locations of artifacts in compressed pictures are found. A strength of the artifact per block is determined as is an overall dark noise artifact strength for each picture. Artifact detection and strength assignment is performed by analyzing candidate areas that could be prone to this type of artifact. Multiple features such as block variance, color information, luminance levels and location of the artifact could be used in this process. Also, median filtering may be used on the identified areas to eliminate isolated areas. A final artifact parameter for each picture can be assessed based on the total number of blocks that are classified as dark noise and also the strength of each macroblock.

US Patent:

20220305046, Sep 29, 2022

Filed:

Jun 5, 2020

Appl. No.:

17/616292

Inventors:

- Pasadena CA, US
Dawn Christianson - Pasadena CA, US
James C. Hamilton - Arcadia CA, US
Zhen Li - La Jolla CA, US
Rui Zhu - San Diego CA, US
Christine Wooddell - Madison WI, US
Tao Pei - Madison WI, US

Assignee:

Arrowhead Pharmaceuticals, Inc. - Pasadena CA

International Classification:

A61K 31/713
A61K 45/06
A61P 1/16

Abstract:

Described are methods for treating alpha-1 antitrypsin deficiency (AATD) in a human patient in need of treatment, using pharmaceutical compositions that include AAT RNAi agents. The pharmaceutical compositions disclosed herein that include AAT RNAi agents, when administered to a human patient in need thereof, treat liver diseases associated with AAT deficiency such as chronic hepatitis, cirrhosis, increased risk of hepatocellular carcinoma, transaminitis, cholestasis, fibrosis, fulminant hepatic failure, and other liver-related diseases.

US Patent:

20150322433, Nov 12, 2015

Filed:

Dec 18, 2013

Appl. No.:

14/652359

Inventors:

- Cambridge MA, US
Gregory T. Copeland - Claremont CA, US
Zhen LI - Westfield NJ, US
Joseph D. Armstrong - Rahway NJ, US

Assignee:

SIRNA THERAPEUTICS, INC. - Cambridge MA

International Classification:

C12N 15/113

Abstract:

This invention relates to the post-synthetic chemical modifications of RNA at the 2′-position on the ribose rings via orthogonal chemistry involving amidation reactions plus metal catalyzed alkyne-azide cycloaddition (click) reactions.