Zhen L Lin

US Patent:

6455571, Sep 24, 2002

Filed:

Oct 19, 1999

Appl. No.:

09/421787

Inventors:

Clarence J. Maring - Palatine IL
Yu Gui Gu - Grayslake IL
Hui-Ju Chen - Grayslake IL
Yuanwei Chen - North Haven CT
David A. Degoey - Kenosha WI
William J. Flosi - Des Plaines IL
Vincent L. Giranda - Gurnee IL
David J. Grampovnik - Waukegan IL
Warren M. Kati - Gurnee IL
Dale J. Kempf - Libertyville IL
April Kennedy - Grayslake IL
Larry L. Klein - Lake Forest IL
Allan C. Krueger - Gurnee IL
Zhen Lin - Gurnee IL
Darold L. Madigan - Elk Grove Village IL
Keith F. McDaniel - Grayslake IL
Steven W. Muchmore - Libertyville IL
Hing L. Sham - Mundelein IL
Kent D. Stewart - Gurnee IL
Vincent S. Stoll - Libertyville IL
Minghua Sun - Libertyville IL
Noah P. Tu - Gurnee IL
Frank L. Wagenaar - Gurnee IL
Gary T. Wang - Niles IL
Sheldon Wang - Grayslake IL
Paul E. Wiedeman - Deerfield IL
Yibo Xu - Ridgefield CT
Ming C. Yeung - Grayslake IL
Chen Zhao - Libertyville IL
Stephen Hanessian - Beaconsfield, CA
Malken Bayrakdarian - Verdun, CA
Xuehong Luo - Montreal, CA

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3140

US Classification:

514423, 514422, 514397, 514365, 514374, 548532, 548533, 548518, 5483147, 548205, 548236, 548237

Abstract:

Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

US Patent:

6518305, Feb 11, 2003

Filed:

Oct 19, 1999

Appl. No.:

09/422093

Inventors:

Clarence J. Maring - Palatine IL
Yuanwei Chen - North Haven CT
David A. Degoey - Kenosha WI
Vincent L. Giranda - Gurnee IL
David J. Grampovnik - Waukegan IL
Yu Gui Gu - Grayslake IL
Warren M. Kati - Gurnee IL
Dale J. Kempf - Libertyville IL
April Kennedy - Grayslake CO
Allan C. Krueger - Gurnee IL
Zhen Lin - Gurnee IL
Darold L. Madigan - Elk Grove Village IL
Steven W. Muchmore - Libertyville IL
Hing L. Sham - Mundelein IL
Kent D. Stewart - Gurnee IL
Vincent S. Stoll - Libertyville IL
Minghua Sun - Libertyville IL
Gary T. Wang - Niles IL
Sheldon Wang - Grayslake IL
Ming C. Yeung - Grayslake IL
Chen Zhao - Libertyville IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31195

US Classification:

514530, 514573, 548236, 548315, 5483451, 560122, 562504

Abstract:

Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

US Patent:

6831096, Dec 14, 2004

Filed:

Sep 24, 2002

Appl. No.:

10/253152

Inventors:

Clarence J. Maring - Palatine IL
Yu Gui Gu - Grayslake IL
Hui-Ju Chen - Grayslake IL
Yuanwei Chen - North Haven CT
David A. Degoey - Kenosha WI
William J. Flosi - Des Plaines IL
Vincent L. Giranda - Gurnee IL
David J. Grampovnik - Waukegan IL
Warren M. Kati - Gurnee IL
Dale J. Kempf - Libertyville IL
April Kennedy - Boulder CO
Larry L. Klein - Lake Forest IL
Allan C. Krueger - Gurnee IL
Zhen Lin - Gurnee IL
Darold L. Madigan - Elk Grove Village IL
Keith F. McDaniel - Wauconda IL
Steven W. Muchmore - Libertyville IL
Hing L. Sham - Mundelein IL
Kent D. Stewart - Gurnee IL
Vincent S. Stoll - Libertyville IL
Minghua Sun - Libertyville IL
Noah P. Tu - Gurnee IL
Frank L. Wagenaar - Gurnee IL
Gary T. Wang - Niles IL
Sheldon Wang - Grayslake IL
Paul E. Wiedeman - Deerfield IL
Yibo Xu - New Milford CT
Ming C. Yeung - Grayslake IL
Chen Zhao - Libertyville IL
Stephen Hanessian - Beaconsfield, CA
Malken Bayrakdarian - Verdun, CA
Xuehong Luo - Montreal, CA

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3140

US Classification:

514423

Abstract:

Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

US Patent:

20050181037, Aug 18, 2005

Filed:

Nov 23, 2004

Appl. No.:

10/996536

Inventors:

Moghis Ahmad - Wadsworth IL, US
Zhen Lin - Gurnee IL, US
Shoukath Ali - Lake Bluff IL, US
Imran Ahmad - Wadsworth IL, US

Assignee:

NEOPHARM, INC. - Lake Forest IL

International Classification:

A61K048/00
A61K038/16
C07H021/04
C07K014/47
A61K009/127
A61K031/675

US Classification:

424450000, 514044000, 514007000, 514025000, 514079000, 514124000, 530324000, 536023100, 554079000, 435458000

Abstract:

The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation. The reaction schemes can be used to generate new forms of cardiolipin, including cardiolipin variants. The cardiolipin prepared by the present methods can conveniently be incorporated into liposomes and other lipid formulations that can also include active agents such as hydrophobic or hydrophilic drugs. Such formulations can be used to treat diseases or in diagnostic and/or analytical assays. Liposomes also can include ligands, e.g., for targeting them to a cell type or specific tissue.

US Patent:

20200209250, Jul 2, 2020

Filed:

Dec 27, 2019

Appl. No.:

16/729067

Inventors:

- Abbott Park IL, US
Patrick J. Macdonald - Abbott Park IL, US
Kerry M. Swift - Abbott Park US, US
Sergey Y. Tetin - Abbott Park IL, US
Brenda Calfin - Abbott Park IL, US
Zhen Lin - Abbott Park IL, US
Richard Haack - Abbott Park IL, US
Mark R. Pope - Abbott Park IL, US
John Prostko - Abbott Park IL, US
Xiaoxing Qiu - Abbott Park IL, US
Felicia Bogdan - Abbott Park IL, US

International Classification:

G01N 33/58
G01N 15/14
G01N 33/543

Abstract:

The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a cross-linked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.