Zheng David Wang

US Patent:

6800764, Oct 5, 2004

Filed:

Nov 26, 2002

Appl. No.:

10/304322

Inventors:

Anthony Frank Kreft - Langhorne PA
Madelene Miyoko Antane - West Windsor NJ
Derek Cecil Cole - New City NY
Dennis Martin Kubrak - Philadelphia PA
Lynn Resnick - Edison NJ
Joseph Raymond Stock - Monroe NY
Zheng Wang - East Brunswick NJ

Assignee:

Wyeth - Madison NJ

International Classification:

C07D33332

US Classification:

549 65, 564302, 564487, 564489

Abstract:

A process is provided for preparing chirally pure S-enantiomers of -amino acids comprising the steps of: a) preparing an organometallic reagent from an alkyl halide of the formula (R) CH(CH ) CH X; b) adding the organometallic reagent to carbon dioxide to afford a carboxylic acid; c) activating the carboxylic acid with an acid chloride, phosphorus trichloride, acid anhydride, or thionyl chloride in the presence of a tertiary amine base; d) reacting the product of step c) with an alkali metal salt of S-4-benzyl-2-oxazolidinone; e) treating the product of step d) with a strong non-nucleophilic base to form an enolate anion; f) trapping the enolate anion with 2,4,6-triisopropylbenzenesulfonyl azide to afford an oxazolidinone azide; g) hydrolyzing the oxazolidinone azide with an aqueous base to afford an -azido acid; h) reducing the -azido acid to the -amino acid; and i) recrystallizing the -amino acid to the chirally pure -amino acid. A process is also provided for preparing chirally pure S-enantiomers of -amino alcohols further comprising the steps of reducing the crude -amino acid to the -amino alcohol and recrystallizing the -amino alcohol to the chirally pure -amino alcohol. A process is further provided for preparing chirally pure S enantiomers of N-sulfonyl -amino alcohols further comprising the steps of sulfonylating the -amino alcohol with 5-chloro-thiophene-2-sulfonyl halide; and recrystallizing to afford the chirally pure N-sulfonyl -amino alcohols.

US Patent:

20080114096, May 15, 2008

Filed:

Nov 9, 2006

Appl. No.:

11/598223

Inventors:

Xin Qu - Hefei, CN
Tom Schottman - Flemington NJ, US
Rainer Gruening - Basking Ridge NJ, US
Paul N. Chen - Canandaigua NY, US
Joseph Conte - Monroe Twsp. NJ, US
Zheng Wang - Bridgewater NJ, US
Paaquale P. Vicario - North Plainfield NJ, US
Zichun Lu - Newton PA, US
Karen Meritt - Avon-By-The-Sea NJ, US
Dave Buongiovanni - Manville NJ, US

International Classification:

A61K 8/73
C08L 1/00

US Classification:

524 18, 427294, 4274274, 427457, 524 27, 524 35, 524 47, 524 56, 524 58

Abstract:

The invention provides a network composition comprising a plurality of associated saccharide chains wherein a chain comprises at least one saccharide component; and at least one first monomer, at least one second monomer, or combinations of both; wherein the first monomer is linked to the saccharide component by ester linkages; ether linkages; amide linkages; ketone linkages; or combinations thereof; wherein the second monomer is linked to the saccharide component by ester linkages; ether linkages; amide linkages; ketone linkages; urea linkages; carbamate linkages, aluminum oxide linkages; siloxane linkages; or combinations thereof; wherein first monomers are linked to each other by ester linkages; ether linkages; amide linkages; ketone linkages; or combinations thereof; wherein the first monomer is linked to the second monomer by ester linkages; ether linkages; amide linkages; ketone linkages; urea linkages; carbamate linkages; aluminum oxide linkages; siloxane linkages or combinations thereof; wherein the second monomers are linked to each other by ester linkages; ether linkages; amide linkages; ketone linkages; polyvinyl linkages, polyolefin linkages, urea linkages; carbamate linkages, aluminum oxide linkages, siloxane linkages or combinations thereof; and wherein the saccharide components are linked to each other by ester linkages; ether linkages; amide linkages; ketone linkages; or combinations thereof; wherein the network is capable of adhering to a substrate.

US Patent:

62359444, May 22, 2001

Filed:

Jan 21, 1999

Appl. No.:

9/234572

Inventors:

Thomas V. John - Yardley PA
Chitoor S. Subramaniam - East Brunswick NJ
Zheng Wang - East Brunswick NJ
Richard J. Kucera - Hasbrouck Heights NJ

Assignee:

Creanova Inc. - Somerset NJ

International Classification:

C07C 4128

US Classification:

568667

Abstract:

The present invention relates to a general synthesis for producing secondaryalkoxy-1-alkenes in commercial quantities in good yields by reacting cyclic and acyclic ketones and the corresponding alcohol with a secondary alkyl orthoformate ester in the presence of an acid catalyst, a Lewis acid, ferric chloride being preferred, and recovering the produce as a liquid of high purity.