Zhiqiang A Yang from 2 Rutledge Ct, Plainsboro, NJ 08536, age 60, Phone: (609)2755656

Us Patents

4-Fluoro-Piperidine T-Type Calcium Channel Antagonists
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US Patent:

8501773, Aug 6, 2013
Filed:

Jun 28, 2006
Appl. No.:

11/922399
Inventors:

James C. Barrow - Harleysville PA, US
Craig W. Lindsley - Brentwood TN, US
William D. Shipe - Chalfont PA, US
Zhiqiang Yang - Schwenksville PA, US
David Wisnoski - Quakertown PA, US
Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:

A01N 43/42
A01N 43/40
A61K 31/47
A61K 31/445
C07D 211/00
C07D 295/00
C07D 211/08
C07D 401/00
C07D 405/00
C07D 409/00
C07D 411/00
C07D 413/00
C07D 417/00
C07D 419/00
C07D 421/00
US Classification:

514314, 514317, 546184, 546192
Abstract:

The present invention is directed to 4-fluoro-piperidine compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

Quinazolinone T-Type Calcium Channel Antagonists
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US Patent:

20080167329, Jul 10, 2008
Filed:

Mar 8, 2006
Appl. No.:

11/886053
Inventors:

James C. Barrow - Harleysville PA, US
Rowena V. Cube - Harleysville PA, US
Phung Le Ngo - Lansdale PA, US
Kenneth E. Rittle - Green Lane PA, US
Zhiqiang Yang - Schwenksville PA, US
Steven D. Young - Lansdale PA, US
International Classification:

A61K 31/517
C07D 239/80
A61P 43/00
A61P 25/08
A61P 25/02
A61P 25/16
A61P 25/00
A61P 25/18
A61P 25/20
US Classification:

51426631, 544286
Abstract:

The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

Quinazolinone T-Type Calcium Channel Antagonists
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US Patent:

20100261741, Oct 14, 2010
Filed:

Jun 28, 2010
Appl. No.:

12/824702
Inventors:

James C. Barrow - Harleysville PA, US
Rowena V. Cube - Harleysville PA, US
Phung Le Ngo - Lansdale PA, US
Kenneth E. Rittle - Green Lane PA, US
Zhiqiang Yang - Harleysville PA, US
Steven D. Young - Harleysville PA, US
Assignee:

Merck - Rahway NJ
International Classification:

A61K 31/517
C07D 239/82
A61P 25/08
A61P 25/16
A61P 25/18
A61P 25/22
A61P 25/24
A61P 25/30
C07D 239/80
US Classification:

51426631, 544286, 5142663
Abstract:

The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

Oxazole Derivatives Useful As Modulators Of Faah
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US Patent:

20130018048, Jan 17, 2013
Filed:

Apr 4, 2011
Appl. No.:

13/635303
Inventors:

ZhiQiang Yang - Schwenksville PA, US
Philippe G. Nantermet - Lansdale PA, US
Constantine Kreatsoulas - Elkins Park PA, US
Keith P. Moore - Bensalem PA, US
Evan Foster Shalen - Mill Valley CA, US
Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:

C07D 263/46
A61P 19/02
A61P 29/00
A61P 25/00
A61P 25/06
A61P 25/20
A61P 25/28
A61P 25/16
C07D 413/14
C07D 471/04
C07D 491/08
C07D 417/14
C07D 487/04
C07D 413/04
A61K 31/444
A61K 31/4545
A61K 31/506
A61K 31/4439
A61K 31/5377
A61K 31/496
A61K 31/437
A61K 31/422
A61K 31/541
A61K 31/433
A61K 31/4245
A61K 31/427
A61K 31/421
US Classification:

5142278, 548228, 514376, 546256, 546194, 544316, 5462714, 544131, 544364, 546113, 546119, 544331, 544369, 544137, 544 582, 548138, 548143, 548200, 514333, 514318, 514274, 514340, 5142368, 5142531, 514300, 514303, 514275, 51425402, 514363, 514364, 514365
Abstract:

The present invention is directed to certain Oxazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.

Carbamate And Urea Compounds As Multikinase Inhibitors
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US Patent:

20210163445, Jun 3, 2021
Filed:

Dec 10, 2018
Appl. No.:

16/770697
Inventors:

- North Brunswick NJ, US
Zhiqiang Yang - Westfield NJ, US
Francis Lee - Yardley PA, US
John Qiang Tan - North Brunswick NJ, US
International Classification:

C07D 401/12
C07D 215/22
C07D 487/04
C07D 487/08
C07D 403/12
Abstract:

The present disclosure describes carbamate and urea compounds as novel multikinase inhibitors and methods for preparing them. The pharmaceutical compositions comprising such multikinase inhibitors and methods of using them for treating cancer, infectious diseases, and other disorders associated with kinases are also described.

Macrocyclic Compounds As Trk Kinase Inhibitors And Uses Thereof
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US Patent:

20200385386, Dec 10, 2020
Filed:

Oct 11, 2018
Appl. No.:

16/760790
Inventors:

- North Brunswick NJ, US
Zhiqiang Yang - Westfield NJ, US
Francis Lee - Yardley PA, US
John Qiang Tan - North Brunswick NJ, US
International Classification:

C07D 471/22
C07D 487/22
C07D 498/22
Abstract:

The present disclosure describes novel TRK kinase inhibitors and methods for preparing them. The pharmaceutical compositions comprising such TRK kinase inhibitors and methods of using them for treating cancer, infectious diseases, and other disorders are also described.

Heterocyclic Compounds As Prmt5 Inhibitors
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US Patent:

20200369667, Nov 26, 2020
Filed:

Nov 1, 2018
Appl. No.:

16/767077
Inventors:

- North Brunswick NJ, US
Zhiqiang Yang - Westfield NJ, US
Francis Lee - Yardley PA, US
John Qiang Tan - North Brunswick NJ, US
International Classification:

C07D 487/04
C07D 519/00
C07H 19/14
Abstract:

The present disclosure describes novel PRMT5 inhibitors and methods for preparing them. The pharmaceutical compositions comprising such PRMTS inhibitors and methods of using them for treating cancer, infectious diseases, and other PRMTS associated disorders are also described.

Cyclic Compounds As Immunomodulating Agents
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US Patent:

20200239464, Jul 30, 2020
Filed:

Sep 5, 2018
Appl. No.:

16/648213
Inventors:

- North Brunswick NJ, US
Zhiqiang Yang - Westfield NJ, US
Francis Lee - Yardley PA, US
John Qiang Tan - North Brunswick NJ, US
International Classification:

C07D 471/04
C07D 215/14
C07D 401/08
C07D 401/12
C07D 401/04
Abstract:

The present disclosure describes novel IDO inhibitors and methods for preparing them. The pharmaceutical compositions comprising such IDO inhibitors and methods of using them for treating cancer, infectious diseases, and other disorders are also described