Alice F Ho

US Patent:

6365726, Apr 2, 2002

Filed:

May 22, 2000

Appl. No.:

09/578458

Inventors:

Dennis G. Ballinger - Menlo CA
John Ford - San Mateo CA
Alice Suk-Yue Ho - Union City CA
Hai Shan Lin - Castro Valley CA
Ann M. Pace - Scotts Valley CA

Assignee:

Hyseq, Inc. - Sunnyvale CA

International Classification:

C07H 2104

US Classification:

536 2352, 536 231, 536 235, 536 2431, 435 691, 435 6952, 4353201

Abstract:

The present invention provides novel nucleic acids encoding IL-1 Hy2, a novel member of the Interleukin-1 Receptor Antagonist family, the novel polypeptides encoded by these nucleic acids and uses of these and related products.

US Patent:

6423500, Jul 23, 2002

Filed:

Nov 15, 1999

Appl. No.:

09/439672

Inventors:

Kevin W. Moore - Palo Alto CA
Ying Liu - Mountain View CA
Alice Suk-Yue Ho - Milpitas CA
Bazan Fernando J. - Menlo Park CA
Jimmy C. Tan - Edison NJ
Chuan-Chu Chou - Westfield NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

G01N 3353

US Classification:

435 71, 435 792, 435 691, 435 695, 530351, 5303882, 5303892

Abstract:

Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.

US Patent:

6497870, Dec 24, 2002

Filed:

May 22, 2000

Appl. No.:

09/576755

Inventors:

John Ford - San Mateo CA
Alice Suk-Yue Ho - Union City CA

Assignee:

Hyseq, Inc. - Sunnyvale CA

International Classification:

A61K 4500

US Classification:

424 852, 514 2, 530351

Abstract:

The present invention provides novel therapeutic methods of administering an amount of IL-1Ra to treat IL-18 related disorders. Specifically, the method involves treating IL-18 related disorders such as liver injury, hepatis, hemophagocytic lymphohistiocytosis, multiple sclerosis, tumors, cytotoxicity resulting from antitumor therapy, or other autoimmune disorders with a therapeutically effective amount of IL-1ra, and optionally measuring IFN- and IL-18 activity from human samples.

US Patent:

6541623, Apr 1, 2003

Filed:

May 22, 2000

Appl. No.:

09/576008

Inventors:

John Ford - San Mateo CA
Alice Suk-Yue Ho - Union City CA
Ann Pace - Scotts Valley CA

Assignee:

Hyseq, Inc. - Sunnyvale CA

International Classification:

C07H 2104

US Classification:

536 243, 4352872, 4352883, 4352884, 536 231

Abstract:

The present invention provides novel nucleic acids, the novel polypeptide sequences encoded by these nucleic acids and uses thereof. These novel polynucleotide and polypeptide sequences were determined to be a novel Interleukin-1 Receptor Antagonist.

US Patent:

20020156009, Oct 24, 2002

Filed:

Nov 2, 2001

Appl. No.:

10/003671

Inventors:

Dennis Ballinger - Menlo Park CA, US
John Ford - San Diego CA, US
Alice Ho - Palo Alto CA, US
Haishan Lin - Castro Valley CA, US
Ann Pace - Scotts Valley CA, US
Nancy Mize - Mountain View CA, US

International Classification:

A61K038/17
C07K014/435

US Classification:

514/012000, 530/350000

Abstract:

The present invention provides machine readable storage media comprising a three-dimensional representation of Interleukin-1 Hy2 (IL-1Hy2), useful for designing and producing modulators of its activity and IL-1 Hy2 variants, and therapeutic uses thereof. The present invention also provides novel nucleic acids encoding IL-1 Hy2, the novel polypeptides encoded by these nucleic acids and uses of these and related products.

US Patent:

20030099650, May 29, 2003

Filed:

Jul 25, 2002

Appl. No.:

10/205821

Inventors:

Alice Ho - Palo Alto CA, US
John Ford - San Diego CA, US
Hai-Shan Lin - Castro Valley CA, US
Fabio Rupp - Sunnyvale CA, US

International Classification:

A61K039/395

US Classification:

424/145100

Abstract:

The present invention provides materials and methods of using compositions comprising the IL-1Hy1 polypeptide or inhibitors of IL-1Hy1 activity for treatment of immune cell disorders.

US Patent:

20050175994, Aug 11, 2005

Filed:

Dec 22, 2000

Appl. No.:

10/311827

Inventors:

Bryan Boyle - San Francisco CA, US
Alice Ho - Palo alto CA, US
PING Zhou - Cupertino CA, US
Nancy Mize - Mountain View CA, US
Chiaoyun Kuo - San Jose CA, US
Matthew Arterburn - San Jose CA, US
Y. Tom Tang - San Jose CA, US
Chenghua Liu - San Jose CA, US
Radoje Drmanac - Palo Alto CA, US

International Classification:

C12Q001/68
C07H021/04
A61K038/48
C12N009/64

US Classification:

435006000, 435069100, 435226000, 435320100, 435325000, 536023200, 424094640, 530388260

Abstract:

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel secreted prothrombinase-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human ovary (Hyseq clone identification numbers 773565 (SEQ ID NO: 1) and 7727065 (SEQ ID NO: 11)). Other aspects of the invention include vectors containing processes for producing novel secreted prothrombinase-like polypeptides, and antibodies specific for such polypeptides.

US Patent:

57891923, Aug 4, 1998

Filed:

Aug 23, 1993

Appl. No.:

8/110683

Inventors:

Kevin W. Moore - Palo Alto CA
Ying Liu - Mountain View CA
Alice Suk-Yue Ho - Milpitas CA
J. Fernando Bazan - Menlo Park CA
Jimmy C. Tan - Edison NJ
Chuan-Chu Chou - Westfield NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C12N 1512

US Classification:

435 691

Abstract:

Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.