Alicia J Minor

US Patent:

20230020862, Jan 19, 2023

Filed:

Jul 12, 2022

Appl. No.:

17/862962

Inventors:

- Providence RI, US
Stephanie ROSER - Florham Park NJ, US
Fabiola MUNARIN - Smithfield RI, US
Alicia MINOR - Providence RI, US

International Classification:

A61K 9/06
A61K 47/42
A61K 47/36
A61K 38/18
A61K 38/30

Abstract:

The invention provides a highly versatile system to promote vascularization in ischemic tissue. The system is composed of a fully defined, customizable hydrogel loaded with a potent cocktail of proangiogenic growth factors. The hydrogel's mechanical, degradation, and factor release behavior can be tailored to the specifications of any given target tissue or ischemic disease state. The growth factor cocktail can be optimized for maximal vessel density or size to meet the perfusion specifications required by the tissue. The embodiments of the disclosure concern methods and compositions of the system, with examples of preparation for both injectable and implantable delivery modes.