Ana Martin Miller

age ~51

from Beverly Hills, CA

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Hepatocyte Bioreactor System For Long Term Culture Of Functional Hepatocyte Spheroids
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US Patent:

7575859, Aug 18, 2009
Filed:

Jul 21, 2008
Appl. No.:

12/177017
Inventors:

Paul M. Silber - Ellicott City MD, US
Nancy L. Cowger - Catonsville MD, US
Ana P. Miller - Crofton MD, US
Lanika A. Brown - Gaithersburg MD, US
Albert P. Li - Columbia MD, US
International Classification:

C12N 5/08
US Classification:

435 5, 435325, 435370, 435375, 435383
Abstract:

A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible.

Hepatocyte Bioreactor System For Long Term Culture Of Functional Hepatocyte Spheroids
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US Patent:

7575911, Aug 18, 2009
Filed:

Mar 31, 2008
Appl. No.:

12/059683
Inventors:

Paul M. Silber - Ellicott City MD, US
Nancy L. Cowger - Catonsville MD, US
Ana P. Miller - Crofton MD, US
Lanika A. Brown - Gaithersburg MD, US
Albert P. Li - Columbia MD, US
International Classification:

C12N 5/08
US Classification:

4352351, 435239, 435383, 435370, 435375, 424 937
Abstract:

A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate-metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible.

Hepatocyte Bioreactor System For Long Term Culture Of Functional Hepatocyte Spheroids
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US Patent:

7939248, May 10, 2011
Filed:

Aug 17, 2009
Appl. No.:

12/542505
Inventors:

Paul M. Silber - Ellicott City MD, US
Nancy L. Cowger - Catonsville MD, US
Ana P. Miller - Crofton MD, US
Lanika A. Brown - Gaithersburg MD, US
Albert P. Li - Columbia MD, US
Assignee:

Celsis In Vitro, Inc. - Baltimore MD
International Classification:

C12N 5/00
US Classification:

435 5, 435325, 435370, 435378, 435383
Abstract:

A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible.