Angela C Huang

US Patent:

20190112597, Apr 18, 2019

Filed:

Apr 10, 2018

Appl. No.:

15/949694

Inventors:

- San Fransisco CA, US
Angela Huang - San Mateo CA, US

International Classification:

C12N 15/10
C12N 15/52
C12N 5/074
C12N 5/0735
C12N 5/077
C12N 5/0789
C12N 15/85

Abstract:

This invention provides biosensors, cell models, and methods of their use for monitoring chloride ion, where the biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest, including as detectors of chloride ions, as TempoChloro™ accomplishes.

US Patent:

20180299470, Oct 18, 2018

Filed:

Apr 10, 2018

Appl. No.:

15/949709

Inventors:

- San Francisco CA, US
Angela Huang - San Mateo CA, US

International Classification:

G01N 33/84
C12N 15/79
G01N 33/68
C12N 5/079
G01N 33/50
G01N 33/566
C07K 19/00

Abstract:

This invention provides biosensors, cell models, and methods of their use for monitoring osmolarity. Biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest. Model cells expressing the biosensors can be contacted with putative bioactive agents to determine possible activities, including as detectors of which is pH changes, as TempoOsmo™ accomplishes.

US Patent:

20170146457, May 25, 2017

Filed:

Nov 26, 2016

Appl. No.:

15/361379

Inventors:

- San Fransisco CA, US
ANGELA HUANG - San Mateo CA, US

International Classification:

G01N 21/64
C07K 14/00
G01N 33/58
G01N 33/68
G01N 33/72

Abstract:

This invention provides biosensors, cell models, and methods of their use for monitoring heme and oxygen. Biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest. Model cells expressing the biosensors can be contacted with putative bioactive agents to determine possible activities.

US Patent:

20170016912, Jan 19, 2017

Filed:

Sep 12, 2016

Appl. No.:

15/263182

Inventors:

- San Fransisco CA, US
Angela Huang - San Mateo CA, US

International Classification:

G01N 33/68
C07K 14/705
G01N 33/58
C12N 15/85

Abstract:

This invention provides biosensors, cell models, and methods of their use for monitoring heme, oxygen or ATP. Biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest. Model cells expressing the biosensors can be contacted with putative bioactive agents to determine possible activities.

US Patent:

20170010257, Jan 12, 2017

Filed:

Sep 8, 2016

Appl. No.:

15/259971

Inventors:

- SAN FRANSISCO CA, US
ANGELA HUANG - SAN MATEO CA, US

International Classification:

G01N 33/53
G01N 33/58
C07K 14/47
G01N 33/68
C07K 14/705

Abstract:

This invention provides biosensors, cell models, and methods of their use for monitoring heme, oxygen or ATP. Biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest. Model cells expressing the biosensors can be contacted with putative bioactive agents to determine possible activities.

US Patent:

20160178635, Jun 23, 2016

Filed:

Feb 26, 2016

Appl. No.:

15/055202

Inventors:

- San Fransisco CA, US
Angela Huang - San Mateo CA, US

International Classification:

G01N 33/58
G01N 33/53
G01N 33/72
G01N 33/50
C07K 14/00

Abstract:

This invention provides biosensors, cell models, and methods of their use for monitoring heme, oxygen or ATP. Biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest. Model cells expressing the biosensors can be contacted with putative bioactive agents to determine possible activities.

US Patent:

20150080262, Mar 19, 2015

Filed:

Aug 26, 2014

Appl. No.:

14/469218

Inventors:

- San Francisco CA, US
Angela L. Huang - San Mateo CA, US

International Classification:

G01N 33/50
C07K 14/00

US Classification:

506 10, 530350, 536 231, 435366, 435372, 435455, 435 29

Abstract:

This invention provides biosensors, cell models, and methods of their use for monitoring ionic or voltage responses to contact with bioactive agents. Biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest. Model cells expressing the biosensors can be contacted with putative bioactive agents to determine possible activities.