Anthony A Gatenby

US Patent:

6358716, Mar 19, 2002

Filed:

May 11, 1999

Appl. No.:

09/297928

Inventors:

Ben A. Bulthuis - Leiden, NL
Anthony Arthur Gatenby - Wilmington DE
Sharon Loretta Haynie - Philadelphia PA
Amy Kuang-Hua Hsu - Redwood City CA
Richard D. Lareau - Mountain View CA

Assignee:

E. I. du Ponte de Nemours and Company - Wilmington DE

International Classification:

C12P 720

US Classification:

435159

Abstract:

Recombinant organisms are provided comprising genes encoding a glycerol-3-phosphate dehydrogenase and/or a glycerol-3-phosphatase activity useful for the production of glycerol from a variety of carbon substrates.

US Patent:

6368837, Apr 9, 2002

Filed:

Jul 27, 2000

Appl. No.:

09/627216

Inventors:

Anthony A. Gatenby - Wilmington DE
Sima Sariaslani - Newark DE
Xiao-Song Tang - Hockessin DE
Wei Wei Qi - Drexel Hill PA
Todd Vannelli - Ithaca NY

Assignee:

E. I. du Pont Nemours and Company - Wilmington DE

International Classification:

C12P 742

US Classification:

435146, 435232

Abstract:

The present invention provides several methods for biological production of para-hydroxycinnamic acid (PHCA). The invention is also directed to the discovery of new fungi and bacteria that possess the ability to convert cinnamate to PHCA. The invention relates to developing of a new biocatalyst for conversion of glucose to PHCA by incorporation of the wild type PAL from the yeast into underlining the ability of the wildtype PAL to convert tyrosine to PHCA. The invention is also directed to developing a new biocatalyst for conversion of glucose to PHCA by incorporation of the wildtype PAL from the yeast plus the plant cytochrome P-450 and the cytochrome P-450 reductase into. In yet another embodiment, the present invention provides for the developing of a new biocatalyst through mutagenesis of the wild type yeast PAL which possesses enhanced tyrosine ammonia-lyase (TAL) activity.

US Patent:

6432686, Aug 13, 2002

Filed:

May 10, 1999

Appl. No.:

09/307973

Inventors:

Ben A. Bulthuis - Hoofddorp, NL
Gregory M. Whited - Belmont CA
Donald E. Trimbur - Redwood City CA
Anthony A. Gatenby - Wilmington DE

Assignee:

E. I. du Pont de Nemours and Company - Wilmington DE
Genencor International - Palo Alto CA

International Classification:

C12P 718

US Classification:

435158, 4352523, 4353201

Abstract:

Recombinant organisms are provided comprising genes encoding genes encoding glycerol dehydratase, 1,3-propanediol oxidoreductase, a gene encoding vitamin B receptor precursor(BtuB), a gene encoding vitamin B transport system permease protein(BtuC) and a gene encoding vitamin B transport ATP-binding protein (BtuD). The recombinant microorganism is contacted with a carbon substrate and 1,3-propanediol is isolated from the growth media.

US Patent:

6586229, Jul 1, 2003

Filed:

Jun 1, 2000

Appl. No.:

09/585174

Inventors:

Arie Ben-Bassat - Newark DE
Monica Cattermole - Newark DE
Anthony A. Gatenby - Wilmington DE
Katharine J. Gibson - Wilmington DE
M. Isabel Ramos-Gonzalez - Granada, ES
Juan Ramos - Granada, ES
Sima Sariaslani - Newark DE

Assignee:

North Carolina State University - Raleigh NC

International Classification:

C12N 120

US Classification:

4352523, 4353201, 435 691, 435132, 4352533, 43525234, 435 6, 536 232

Abstract:

Bacterial strains transformed with the pcu genes are useful for the production of para-hydroxybenzoate (PHBA). Applicant has provided the p-cresol utilizing (pcu) and tmoX gene sequences from KR-1, the proteins encoded by these sequences, recombinant plasmids containing such sequences, and bacterial host cells containing such plasmids or integrated sequences. Method for the use of these materials to produce PHBA are also disclosed.

US Patent:

7074608, Jul 11, 2006

Filed:

May 11, 1999

Appl. No.:

09/310001

Inventors:

Nigel S. Dunn-Coleman - Los Gatos CA, US
Anthony A. Gatenby - Wilmington DE, US
Fernando Valle - Burlingame CA, US

Assignee:

E. I. du Pont de Nemours and Company - Wilmington DE
Genencor International, Inc. - Palo Alto CA

International Classification:

C12N 1/20

US Classification:

43525233, 43525411, 4352523, 435419, 435325

Abstract:

Recombinant organisms are provided comprising genes encoding aquacobalamin reductase, cob(II)alamin reductase, cob(I)alamin adenosyltransferase, glycerol dehydratase and 1,3-propanediol oxidoreductase activities useful for the production of 1,3-propanediol from a variety of carbon substrates. More specifically the following nucleotide sequences are provided: btuR, encoding the cob(I)alamin adenosyltransferase enzyme; cobA, encoding the cob(I)alamin adenosyltransferase enzyme; cobO, encoding the cob(I)alamin adenosyltransferase enzyme; dhaB1, encoding the α subunit of the glycerol dehydratase enzyme; dhaB2, encoding the β subunit of the glycerol dehydratase enzyme; dhaB3, encoding the γ subunit of the glycerol dehydratase enzyme; dhaT, encoding oxidoreductase enzyme; the yciK gene isolated from ; the glucose isomerase promoter sequence from ; and the N-terminal amino acid sequence for cob(II)alamin reductase from.

US Patent:

7083953, Aug 1, 2006

Filed:

Jun 19, 2003

Appl. No.:

10/464952

Inventors:

Arie Ben-Bassat - Newark DE, US
Monica Cattermole - Newark DE, US
Anthony A. Gatenby - Wilmington DE, US
Katharine J. Gibson - Wilmington DE, US
M. Isabel Ramos-Gonzalez - Granada, ES
Juan L. Ramos - Granada, ES
Sima Sariaslani - Newark DE, US

Assignee:

North Carolina State University - Raleigh NC

International Classification:

C12P 17/14
C12P 7/00
C12N 15/00
C12N 5/00
C12N 9/00

US Classification:

435120, 435132, 4353201, 4352523, 43525234, 435 691, 435195, 435183

Abstract:

Bacterial strains transformed with the pcu genes are useful for the production of para-hydroxybenzoate (PHBA). Applicant has provided the p-cresol utilizing (pcu) and tmoX gene sequences from KR-1, the proteins encoded by these sequences, recombinant plasmids containing such sequences, and bacterial host cells containing such plasmids or integrated sequences. Method for the use of these materials to produce PHBA are also disclosed.

US Patent:

7195898, Mar 27, 2007

Filed:

Jul 11, 2006

Appl. No.:

11/484129

Inventors:

Arie Ben-Bassat - Newark DE, US
Monica Cattermole - Newark DE, US
Anthony A. Gatenby - Wilmington DE, US
Katharine J. Gibson - Wilmington DE, US
M. Isabel Ramos-Gonzalez - Granada, ES
Juan Ramos - Granada, ES
Sima Sariaslani - Newark DE, US

Assignee:

North Carolina State University - Raleigh NC

International Classification:

C12P 17/14
C12P 7/00
C12N 15/00
C12N 9/00

US Classification:

435120, 435132, 4353201, 43525234, 435 691, 435195, 435183

Abstract:

Bacterial strains transformed with the pcu genes are useful for the production of para-hydroxybenzoate (PHBA). Applicant has provided the p-cresol utilizing (pcu) and tmoX gene sequences from KR-1, the proteins encoded by these sequences, recombinant plasmids containing such sequences, and bacterial host cells containing such plasmids or integrated sequences. Method for the use of these materials to produce PHBA are also disclosed.

US Patent:

7582457, Sep 1, 2009

Filed:

Jun 29, 2006

Appl. No.:

11/479194

Inventors:

Nigel S. Dunn-Coleman - Los Gatos CA, US
Anthony Gatenby - Wilmington DE, US
Fernando Valle - Burlingame CA, US

Assignee:

E.I. du Pont de Nemours and Company - Wilmington DE
Genencor International - Palo Alto CA

International Classification:

C12P 7/18

US Classification:

435158, 43525233, 4352542, 435325, 435189, 435193, 435419, 536 232

Abstract:

Recombinant organisms are provided comprising genes encoding cob(II)alamin reductase, cob(I)alamin adenosyltransferase, glycerol dehydratase and 1,3-propanediol oxidoreductase activities useful for the production of 1,3-propanediol from a variety of carbon substrates.