Robert A Gatenby

US Patent:

20120277245, Nov 1, 2012

Filed:

May 24, 2012

Appl. No.:

13/479638

Inventors:

Robert J. Gillies - Tampa FL, US
David L. Morse - Tampa FL, US
Ariosto Siqueira Silva - Tampa FL, US
Arig A. Ibrahim Hashim - Tampa FL, US
Robert A. Gatenby - Tampa FL, US
Gary Martinez - Temple Terrace FL, US

Assignee:

H. Lee Moffitt Cancer Center and Research Institute, Inc. - Tampa

International Classification:

A61K 31/185
A61K 31/4172
A61P 35/04
A61K 31/14
A61P 35/00
A61K 31/495
A61K 31/198

US Classification:

51425212, 514400, 514578, 514564, 514642

Abstract:

A method of treating cancer or inhibiting metastasis in a subject by increasing intratumoral extracellular pH is presented. The method includes administering to the subject a therapeutically effective amount of a buffer having a pKa greater than 6.1. In an advantageous embodiment the pKa of the buffer is about 7.0. Examples of buffers for increasing extracellular pH include NaHCO, 2-imidazole-1-yl-3-ethoxycarbonylpropionic acid (IEPA), cholamine chloride, N,N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES) and 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES). The method can further include the step of pretreating with one or more chemotherapeutic agents.

US Patent:

49574817, Sep 18, 1990

Filed:

Jul 3, 1989

Appl. No.:

7/374823

Inventors:

Robert A. Gatenby - Wynnewood PA

Assignee:

U.S. Bioscience - Blue Bell PA

International Classification:

A61N 130

US Classification:

604 20

Abstract:

The present invention is directed toward methods for the reduction of the severity of symptoms resulting from tumors, such as pain induced by the pressure exerted on a nerve by the tumor mass. Additionally, methods for the reduction of tumor size are also contemplated.