Asha A Oroskar

US Patent:

8471030, Jun 25, 2013

Filed:

Dec 6, 2010

Appl. No.:

12/928198

Inventors:

Arun Kanti Mandal - Mumbai, IN
Kamlesh Jayantilal Ranbhan - Thane, IN
Ganesh Gurpur Pai - Thane, IN
Abhilesh Agarwal - Chicago IL, US
Rakesh Vikraman Nair Rema - Lisle IL, US
Asha Oroskar - Oak Brook IL, US

Assignee:

Orochem Technologies Inc. - Naperville IL

International Classification:

C07D 215/38

US Classification:

546159

Abstract:

This invention concerns generally with a process for purifying crude pharmaceutical compositions, wherein the crude pharmaceutical composition comprises a sodium salt of Montelukast.

US Patent:

8471052, Jun 25, 2013

Filed:

Nov 20, 2009

Appl. No.:

12/622782

Inventors:

Anil Oroskar - Oak Brook IL, US
Paul Roman Kurek - Barrington IL, US
Asha Oroskar - Oak Brook IL, US

Assignee:

Orochem Technologies Inc. - Naperville IL

International Classification:

C07C 253/00

US Classification:

558313, 558311

Abstract:

A process is disclosed for producing organic nitriles such as Acetonitrile or Hydrogen Cyanide, in which yields may exceed 90%, undesirable by-products are not produced, and handling of ammonia gas is avoided. In one aspect, a process includes preparing a feed including ammonium salts and water; introducing the feed into a reactor containing a catalyst; and heating the feed in the presence of the catalyst. The catalyst may advantageously include molybdenum on a silica or silica alumina support. The feed may be ammonium acetate in water with about 50 wt % ammonium acetate and the balance water or ammonium formate in water. In another aspect, a process includes preparing a feed including ammonium hydroxide and acetic acid; introducing the feed into a reactor containing a catalyst; and heating the feed in the presence of the catalyst.

US Patent:

20070068873, Mar 29, 2007

Filed:

Sep 26, 2005

Appl. No.:

11/234798

Inventors:

Anil Oroskar - Oak Brook IL, US
Saurabh Parikh - Villa Park IL, US
Asha Oroskar - Oak Brook IL, US
Kenneth Johnson - Stoughton WI, US
Anthony Escarcega - Madison WI, US

International Classification:

B01D 15/08

US Classification:

210659000, 210198300, 210424000, 137625400

Abstract:

A unique valve assembly for simulated bed moving chromatography employs a combination of pressure compatible sealable materials that permit minimal frictional interaction between moving parts, ensures alignment of parts, and provides a method for conducting SMB countercurrent chromatography on a small scale, in which purity and separation efficiency are enhanced. Machine designs are disclosed which embody the SMB concepts. Finally, a quick disconnect connector and adaptor is provided for mounting chromatographic columns in an SMB device. Demonstration of this system in a fructose-glucose isomer separation with purity-recovery trade-off for this device is also presented.

US Patent:

20130065771, Mar 14, 2013

Filed:

Sep 9, 2011

Appl. No.:

13/199811

Inventors:

Asha A. Oroskar - Oak Brook IL, US
Anil R. Oroskar - Oak Brook IL, US
John P. LaCava - New York NY, US
Michael P. Rout - New York NY, US

Assignee:

The Rockefeller University - New York NY
Orochem Technologies Inc. - Lombard IL

International Classification:

C40B 30/04
C40B 60/12
G01N 30/02
C40B 60/08

US Classification:

506 9, 506 37, 506 39, 422 70

Abstract:

This invention relates to a kit and a method for the collection and analysis of complex protein mixtures. More particularly, the invention relates to a kit comprising a single barrel filtration well or a multi-well filtration plate wherein each well comprises an upper filtration zone; a lower filtration zone; a conical flow director zone; and, an elution tip, wherein the upper filtration zone and the lower filtration zone are separated by a retainer ring disposed within the lower filtration zone. The upper filtration zone comprises an upper collection zone, a sponge zone, and a deep bed filtration zone; and, the lower filtration zone comprises the retainer ring, a supported hydrophilic membrane and a lower bed filtration media. When used with an array of selected buffer solutions, the multi-well filtration plate can provide accurate, automated, high-throughput protein analysis by affinity chromatography.

US Patent:

20130277303, Oct 24, 2013

Filed:

Jan 31, 2013

Appl. No.:

13/756078

Inventors:

Asha A. Oroskar - Oak Brook IL, US

Assignee:

OROCHEM TECHNOLOGIES, INC. - LOMBARD IL

International Classification:

B01J 20/28
B01D 15/26

US Classification:

210635, 2101982, 428402

Abstract:

The present invention relates to a porous sub-2 chiral stationary phase agent that provides stability and increased productivity for chiral separation using HPLC and UHPLC methods. It was surprisingly discovered that highly stable and backpressure resistant coated and at least partially covalently bonded chiral stationary phase agents having an average particle diameter less than 2 microns can be obtained by maintaining a pore ratio of from 0.0042 to about 0.010.

US Patent:

20130277304, Oct 24, 2013

Filed:

Feb 27, 2013

Appl. No.:

13/779292

Inventors:

Asha A. Oroskar - Oak Brook IL, US

Assignee:

OROCHEM TECHNOLOGIES, INC. - Lombard IL

International Classification:

B01J 20/28

US Classification:

210635, 2101982

Abstract:

The present invention relates to chiral separation column for use with supercritical fluid chromatography (SFC) containing a porous sub-2 chiral stationary phase agent that offered significant savings in run times and solvent use over the more conventional chiral columns using SFC methods. It was surprisingly discovered that SFC columns containing highly stable and backpressure resistant sub-2 micron stationary phase agents which were either coated or at least partially covalently bonded with polysaccharide or derivatized polysaccharide and which have an average particle diameter less than 2 microns can be obtained by maintaining a pore ratio of from 0.0042 to about 0.010 provide improved efficiency.

US Patent:

20130317261, Nov 28, 2013

Filed:

Mar 15, 2013

Appl. No.:

13/837355

Inventors:

Rahul K. Keswani - Lisle IL, US
Wahab Mahmood - Niles IL, US
Asha A. Oroskar - Oak Brook IL, US

Assignee:

OROCHEM TECHNOLOGIES, INC. - Lombard IL

International Classification:

C07C 29/76

US Classification:

568917

Abstract:

Disclosed is an improved SMB process incorporating novel regeneration steps for the separation of ethanol associated oxygenates such as butanediol from a dilute mixture of ethanol and associated oxygenates in water in the presence of organic compounds derived from a biofermentation process. Applicant discovered that increasing the number of raffinate streams alone or in combination with a hot regeneration zone within the SMB cycle can significantly reduce the capital and operating costs associated with the incorporation of the SMB process in a complex for the production of ethanol and butanediol from biofermentation effluent. The process is useful for removing water from dilute aqueous mixtures of organic compounds comprising ethanol in dilute concentration in water and produced by fermentation, biomass extraction, biocatalytic and enzymatic processes which are not economically recoverable by conventional distillation methods.

US Patent:

20210379508, Dec 9, 2021

Filed:

Aug 24, 2021

Appl. No.:

17/410735

Inventors:

- Naperville IL, US
Anil R. Oroskar - Oak Brook IL, US
Asha A. Oroskar - Oak Brook IL, US

Assignee:

Orochem Technologies Inc. - Naperville IL

International Classification:

B01D 15/18
C07H 15/24
B01D 15/36
B01D 61/02
B01D 61/14
A23L 27/30
A23L 5/20
B01D 61/58
B01D 15/32
B01D 61/04
C07H 1/08

Abstract:

Disclosed is a continuous process for the purification of steviol glycosides such as Rebaudioside D and/or Rebaudioside M extracted from the dried stevia leaves or extracted from a fermentation broth using continuous simulated moving bed processes and nanofiltration without the addition of organic solvents to obtain a purified steviol product comprising sweet steviol glycosides. The sweet steviol glycosides can be used as substitutes for caloric sweeteners in beverages and in other food items.