Bin Q Jiang

US Patent:

7132432, Nov 7, 2006

Filed:

Jun 2, 2004

Appl. No.:

10/858978

Inventors:

Jingwu Duan - Yardley PA, US
James Sheppeck - Newtown PA, US
Bin Jiang - Norristown PA, US
Lihua Chen - Boothwyn PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/147
C07D 453/02

US Classification:

514314, 546135

Abstract:

The present invention provides compounds of Formula (I):.

US Patent:

7294624, Nov 13, 2007

Filed:

Dec 17, 2002

Appl. No.:

10/321144

Inventors:

Jingwu Duan - Yardley PA, US
Bin Jiang - Norristown PA, US
Lihua Chen - Boothwyn PA, US
Zhonghui Lu - Wilmington DE, US
Joseph Barbosa - Lambertville NJ, US
William J. Pitts - Newtown PA, US

Assignee:

Bristol Myers Squibb Company - Princeton NJ

International Classification:

A01N 43/58
A61K 31/50
C07D 237/00
C07D 239/02

US Classification:

514247, 514256, 544224, 544242, 544299

Abstract:

The present application describes novel barbituric acid derivatives of formula I:.

US Patent:

7569689, Aug 4, 2009

Filed:

Jan 13, 2005

Appl. No.:

11/034652

Inventors:

Jingwu Duan - Yardley PA, US
Bin Jiang - Norristown PA, US
James Sheppeck - Newtown PA, US
John L. Gilmore - Yardley PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/498
C07D 417/14

US Classification:

544343, 514250

Abstract:

A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I).

US Patent:

7592461, Sep 22, 2009

Filed:

Dec 20, 2006

Appl. No.:

11/642508

Inventors:

Jingwu Duan - Yardley PA, US
Bin Jiang - Norristown PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/426
A61K 31/433
C07D 277/46
C07D 285/135

US Classification:

548195, 514363, 514371, 548139

Abstract:

Novel non-steroidal compounds are provided that are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases having the structure of formula (I):.

US Patent:

7595317, Sep 29, 2009

Filed:

Apr 5, 2007

Appl. No.:

11/696847

Inventors:

Jingwu Duan - Yardley PA, US
Bin Jiang - Norristown PA, US
Lihua Chen - Boothwyn PA, US
Zhonghui Lu - King of Prussia PA, US
Joseph Barbosa - Lambertville NJ, US
William J. Pitts - Newtown PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A01N 43/58
A61K 31/50
C07D 237/00
C07D 239/02

US Classification:

514247, 514256, 544224, 544242, 544299

Abstract:

The present application describes novel barbituric acid derivatives of formula I:.

US Patent:

7625921, Dec 1, 2009

Filed:

Jan 13, 2005

Appl. No.:

11/034822

Inventors:

Jingwu Duan - Yardley PA, US
James Sheppeck - Newtown PA, US
Bin Jiang - Norristown PA, US
John L. Gilmore - Yardley PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/4748
C07D 401/14
C07D 417/12

US Classification:

514289, 546 74, 546 63, 514286

Abstract:

A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I).

US Patent:

7888381, Feb 15, 2011

Filed:

Jun 13, 2006

Appl. No.:

11/451660

Inventors:

Jingwu Duan - Yardley PA, US
Zhonghui Lu - King of Prussia PA, US
David S. Weinstein - East Windsor NJ, US
Bin Jiang - Norristown PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 231/56
A01N 43/56

US Classification:

514406, 5483601

Abstract:

Non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I).

US Patent:

8304539, Nov 6, 2012

Filed:

Feb 5, 2009

Appl. No.:

12/866270

Inventors:

Jingwu Duan - Yardley PA, US
David S. Weinstein - East Windsor NJ, US
Bin Jiang - Norristown PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 491/147
C07D 413/00

US Classification:

544126, 546 83

Abstract:

Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including metabolic and inflammatory and immune diseases or disorders, having the structure of formula (I): an enantiomer, diastereomer, or taυtomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; •A is a S- to 8-membered carbocyclic ring or a S- to 8-membered heterocyclic ring; Band Brings are pyridyl rings, wherein the Band Brings are each fused to the A ring and the Bring is optionally substituted by one to three groups which are the same or different and are independently selected from R, R, and R, and the Bring is optionally substituted by one to three groups which are the same or different and are independently selected from R, R, and RJ, J, and Jare at each occurrence the same or different and are independently -AQA-; Q is a bond, O, S, S(O), or S(O); Aand Aare the same or different and are at each occurrence independently selected from a bond, Calkylene, substituted Calkylene, Calkenylene, and substituted Calkenylene, provided that Aand Aare chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; Rto Rare as defined herein.