Bin Zhou

US Patent:

8103435, Jan 24, 2012

Filed:

Jul 28, 2008

Appl. No.:

12/181249

Inventors:

Chaowei Yang - Gaithersburg MD, US
Ying Cao - Fairfax VA, US
Jibo Xie - Fairfax VA, US
Bin Zhou - Fairfax VA, US

Assignee:

George Mason Intellectual Properties, Inc. - Fairfax VA

International Classification:

G06G 7/76

US Classification:

701117

Abstract:

A near real-time physical transportation network routing system comprising: a traffic simulation computing grid and a dynamic traffic routing service computing grid. The traffic simulator produces traffic network travel time predictions for a physical transportation network using a traffic simulation model and common input data. The physical transportation network is divided into a multiple sections. Each section has a primary zone and a buffer zone. The traffic simulation computing grid includes multiple of traffic simulation computing nodes. The common input data includes static network characteristics, an origin-destination data table, dynamic traffic information data and historical traffic data. The dynamic traffic routing service computing grid includes multiple dynamic traffic routing computing nodes and generates traffic route(s) using the traffic network travel time predictions.

US Patent:

20060184452, Aug 17, 2006

Filed:

Oct 14, 2003

Appl. No.:

10/685302

Inventors:

John Barnes - Leesburg VA, US
Sai Alluru - Ashburn VA, US
Derek Benner - McLean VA, US
Naja Buddharaju - Ashburn VA, US
Taj Chadha - Ashburn VA, US
Bonnie Kidwell - Bealeton VA, US
Josh Nan - Fairfax VA, US
Todd Safford - Bethesda MD, US
Xan Schmickel - Vienna VA, US
Jack Sponsler - Ashburn VA, US
Kimberly Weaver - Fairfax VA, US
Bin Zhou - Oak Hill VA, US
Peter Davies - Ashburn VA, US
Lei Zhang - , US

International Classification:

G06Q 99/00
H04L 9/00
H04K 1/00

US Classification:

705050000

Abstract:

An electronic document management system. The system includes a document entry module; a document management module; and a real time digital certificate generator for effecting electronic signatures. In the preferred embodiment, the system further includes a document repository module for storing documents and for accessing documents.

US Patent:

20100077403, Mar 25, 2010

Filed:

Sep 23, 2009

Appl. No.:

12/565353

Inventors:

Chaowei Yang - Gaithersburg MD, US
Bin Zhou - Fairfax VA, US

International Classification:

G06F 9/46

US Classification:

718104

Abstract:

A centralized scheduling server for scheduling fine-grained near real-time applications includes network ports, a central managing application, functional library(ies) and service processes. One port communicates with processing nodes over a private computer network. Processing nodes include processing node report processor node status to the server and execute scheduled tasks. The other port communicates with user devices through a public network. The central managing application manages fine-grained near real-time application. The functional library provides middleware core functionality. The service processes include: a resource manager, a submitter to place tasks on a task queue; and a dispatcher to dispatch tasks to processing nodes. A work flow process runs an optimized scheduling algorithm.

US Patent:

20100239617, Sep 23, 2010

Filed:

Dec 9, 2009

Appl. No.:

12/633995

Inventors:

Peter PUSHKO - Frederick MD, US
Yingyun Wu - Gaithersburg MD, US
Michael Massare - Mt. Airy MD, US
Ye Liu - Laurel MD, US
Gale Smith - Gaithersburg MD, US
Bin Zhou - Gaithersburg MD, US

International Classification:

A61K 39/155
C07K 14/135
C07H 21/02
C12N 5/10
C12N 7/00
A61K 9/00
A61P 31/14

US Classification:

424400, 530350, 536 234, 435348, 4241861, 4352351

Abstract:

The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.

US Patent:

20220354944, Nov 10, 2022

Filed:

May 4, 2022

Appl. No.:

17/736452

Inventors:

- Gaithersburg MD, US
Bin ZHOU - Clarksburg MD, US
Jing-Hui TIAN - Germantown MD, US
Alyse D. PORTNOFF - Gaithersburg MD, US
Michael J. MASSARE - Mt. Airy MD, US
Vivek SHINDE - Gaithersburg MD, US
Louis FRIES - Ellicott City MD, US
Gale SMITH - Germantown MD, US

International Classification:

A61K 39/145
A61K 39/215
A61P 31/16
A61K 9/51

Abstract:

Disclosed herein are compositions and methods for inducing immune responses against both influenza and coronaviruses. Provided herein are compositions and methods of using the same, wherein the compositions comprise: (a) a coronavirus S (CoV S) glycoprotein in the form of a detergent-core nanoparticle, wherein the detergent is a non-ionic detergent; (b) at least three hemagglutinin (HA) glycoproteins, wherein each HA glycoprotein is from a different influenza strain; and (c) a pharmaceutically acceptable buffer.

US Patent:

20200030436, Jan 30, 2020

Filed:

Oct 11, 2019

Appl. No.:

16/599568

Inventors:

- Gaithersburg MD, US
Yingyun WU - Clarksburg MD, US
Michael J. MASSARE - Mt. Airy MD, US
Ye LIU - Clarksville MD, US
Gale SMITH - Germantown MD, US
Bin ZHOU - Clarksburg MD, US

International Classification:

A61K 39/155
A61K 39/12
C07K 14/005
C12N 7/00
A61K 9/00
A61K 39/39
A61K 9/107

Abstract:

The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.

US Patent:

20150359872, Dec 17, 2015

Filed:

Aug 28, 2015

Appl. No.:

14/839247

Inventors:

- Gaithersburg MD, US
Yingyun Wu - Gaithersburg MD, US
Michael J. Massage - Mt. Airy MD, US
Ye Liu - Laurel MD, US
Gale Smith - Gaithersburg MD, US
Bin Zhou - Gaithersburg MD, US

International Classification:

A61K 39/155
A61K 9/107
A61K 9/00
C07K 14/005
C12N 7/00

Abstract:

The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.

US Patent:

20150265698, Sep 24, 2015

Filed:

Jun 4, 2015

Appl. No.:

14/730805

Inventors:

- Gaithersburg MD, US
Yingyun Wu - Gaithersburg MD, US
Michael J. Massare - Mt. Airy MD, US
Ye Liu - Laurel MD, US
Gale Smith - Gaithersburg MD, US
Bin Zhou - Gaithersburg MD, US

International Classification:

A61K 39/155
C12N 7/00

Abstract:

The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.