Bin Bin Zhou

US Patent:

8103435, Jan 24, 2012

Filed:

Jul 28, 2008

Appl. No.:

12/181249

Inventors:

Chaowei Yang - Gaithersburg MD, US
Ying Cao - Fairfax VA, US
Jibo Xie - Fairfax VA, US
Bin Zhou - Fairfax VA, US

Assignee:

George Mason Intellectual Properties, Inc. - Fairfax VA

International Classification:

G06G 7/76

US Classification:

701117

Abstract:

A near real-time physical transportation network routing system comprising: a traffic simulation computing grid and a dynamic traffic routing service computing grid. The traffic simulator produces traffic network travel time predictions for a physical transportation network using a traffic simulation model and common input data. The physical transportation network is divided into a multiple sections. Each section has a primary zone and a buffer zone. The traffic simulation computing grid includes multiple of traffic simulation computing nodes. The common input data includes static network characteristics, an origin-destination data table, dynamic traffic information data and historical traffic data. The dynamic traffic routing service computing grid includes multiple dynamic traffic routing computing nodes and generates traffic route(s) using the traffic network travel time predictions.

US Patent:

20100077403, Mar 25, 2010

Filed:

Sep 23, 2009

Appl. No.:

12/565353

Inventors:

Chaowei Yang - Gaithersburg MD, US
Bin Zhou - Fairfax VA, US

International Classification:

G06F 9/46

US Classification:

718104

Abstract:

A centralized scheduling server for scheduling fine-grained near real-time applications includes network ports, a central managing application, functional library(ies) and service processes. One port communicates with processing nodes over a private computer network. Processing nodes include processing node report processor node status to the server and execute scheduled tasks. The other port communicates with user devices through a public network. The central managing application manages fine-grained near real-time application. The functional library provides middleware core functionality. The service processes include: a resource manager, a submitter to place tasks on a task queue; and a dispatcher to dispatch tasks to processing nodes. A work flow process runs an optimized scheduling algorithm.

US Patent:

20150359872, Dec 17, 2015

Filed:

Aug 28, 2015

Appl. No.:

14/839247

Inventors:

- Gaithersburg MD, US
Yingyun Wu - Gaithersburg MD, US
Michael J. Massage - Mt. Airy MD, US
Ye Liu - Laurel MD, US
Gale Smith - Gaithersburg MD, US
Bin Zhou - Gaithersburg MD, US

International Classification:

A61K 39/155
A61K 9/107
A61K 9/00
C07K 14/005
C12N 7/00

Abstract:

The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.

US Patent:

20150265698, Sep 24, 2015

Filed:

Jun 4, 2015

Appl. No.:

14/730805

Inventors:

- Gaithersburg MD, US
Yingyun Wu - Gaithersburg MD, US
Michael J. Massare - Mt. Airy MD, US
Ye Liu - Laurel MD, US
Gale Smith - Gaithersburg MD, US
Bin Zhou - Gaithersburg MD, US

International Classification:

A61K 39/155
C12N 7/00

Abstract:

The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.

US Patent:

20150266930, Sep 24, 2015

Filed:

Jun 4, 2015

Appl. No.:

14/730809

Inventors:

- Gaithersburg MD, US
Yingyun Wu - Gaithersburg MD, US
Michael J. Massare - Mt. Airy MD, US
Ye Liu - Laurel MD, US
Gale Smith - Gaithersburg MD, US
Bin Zhou - Gaithersburg MD, US

International Classification:

C07K 14/005
A61K 39/155
C12N 7/00
A61K 9/00
A61K 39/39

Abstract:

The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.

US Patent:

20140294879, Oct 2, 2014

Filed:

Mar 21, 2014

Appl. No.:

14/221675

Inventors:

- Gaithersburg MD, US
Yingyun WU - Gaithersburg MD, US
Michael J. MASSARE - Mt. Airy MD, US
Ye LIU - Laurel MD, US
Gale SMITH - Gaithersburg MD, US
Bin ZHOU - Gaithersburg MD, US

Assignee:

NOVAVAX, INC. - Gaithersburg MD

International Classification:

C07K 14/005

US Classification:

4241861, 530350, 536 234, 435348

Abstract:

The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.

US Patent:

20140234372, Aug 21, 2014

Filed:

Apr 14, 2014

Appl. No.:

14/252043

Inventors:

- Gaithersburg MD, US
Peter Pushko - Rockville MD, US
Kutub Mahmood - Rockville MD, US
Bin Zhou - Rockville MD, US

International Classification:

A61K 39/145

US Classification:

4242091

Abstract:

The present invention discloses novel influenza virus-like particles (VLPs) that contain chimeric proteins or influenza membrane proteins. The chimeric proteins are derived from fragments of influenza membrane proteins fused to heterologous proteins. The invention includes antigenic formulations and vaccines comprising VLPs of the invention as well as methods of making and administering VLPs to vertebrates, including methods of inducing immunity to infections, such as influenza.