Cheuk Yui Leung

US Patent:

20210284736, Sep 16, 2021

Filed:

May 20, 2021

Appl. No.:

17/325268

Inventors:

- Brighton MA, US
Rachel Rennard - Stoneham MA, US
Amanda Frank Oliphant - Boston MA, US
Cheuk Lun Leung - Quincy MA, US
Benjamin Jacob Wolf - Seattle WA, US
Ugur Eskiocak - Somerville MA, US
Pearl Bakhru - Ashland MA, US
Diana I. Albu - Windham NH, US

International Classification:

C07K 16/28
A61P 35/00

Abstract:

The present disclosure relates to compositions and methods for inhibiting tumor evasion by reducing immune checkpoint suppression. In some embodiments, provided herein are compositions that block the interaction between PD-1 and its ligand (e.g., PD-1 and/or PD-L2) while promoting the interaction of the cells on which PD-1 and its ligand are expressed. Also provided are methods of using such compositions.

US Patent:

20200181266, Jun 11, 2020

Filed:

Nov 13, 2019

Appl. No.:

16/682756

Inventors:

- Cambridge MA, US
Rachel Rennard - Cambridge MA, US
Amanda Frank Oliphant - Cambridge MA, US
Cheuk Lun Leung - Cambridge MA, US
Benjamin Jacob Wolf - Cambridge MA, US
Ugur Eskiocak - Cambridge MA, US
Pearl Bakhru - Cambridge MA, US
Diana I. Albu - Cambridge MA, US

International Classification:

C07K 16/28
A61P 35/00

Abstract:

The present disclosure relates to compositions and methods for inhibiting tumor evasion by reducing immune checkpoint suppression. In some embodiments, provided herein are compositions that block the interaction between PD-1 and its ligand (e.g., PD-1 and/or PD-L2) while promoting the interaction of the cells on which PD-1 and its ligand are expressed. Also provided are methods of using such compositions.