Cu C Nguyen

US Patent:

20190125753, May 2, 2019

Filed:

Apr 20, 2017

Appl. No.:

16/095290

Inventors:

- Los Angeles CA, US
Michael McMillan - Alhambra CA, US
Yusuke Higuchi - Los Angeles CA, US
Michael Kahn - Altadena CA, US
Cu D. Nguyen - Azusa CA, US

International Classification:

A61K 31/53
A61K 31/519
A61P 7/06

Abstract:

Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein Ris hydrogen or C-Calkyl; ring A is cyclohexyl or phenyl, optionally substituted; ring B is aryl or a nitrogen-containing heteroaryl, optionally substituted; ring C is phenyl substituted with hydroxyl; each L, Land Lis independently C-Calkyl, —CONR— or —CONR—X—C-Calkyl-, each optionally substituted; Ris hydrogen or C-Calkyl; and X is a bond or a 5-6 membered heterocycle containing up to 3 ring heteroatoms; and methods of use such as a method for increasing hematopoiesis, for enhancing expansion of a hematopoietic stem cell (HSC), or for inhibiting an interaction between a β-, and/or γ-catenin protein in a cell or a subject by administering a compound of Formula (I) to the subject.