Cu Van Nguyen

US Patent:

7232822, Jun 19, 2007

Filed:

Mar 17, 2004

Appl. No.:

10/803179

Inventors:

Sung Hwan Moon - Kyunggi-do, KR
Jae Uk Chung - Kyunggi-do, KR
Sung Chan Lee - Kyunggi-do, KR
Masakatsu Eguchi - Bellevue WA, US
Michael Kahn - Kirkland WA, US
Kwang Won Jeong - Seoul, KR
Cu Nguyen - Arlington WA, US

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

C07D 487/04
A61K 31/53

US Classification:

514243, 544184

Abstract:

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

US Patent:

7566711, Jul 28, 2009

Filed:

Apr 15, 2005

Appl. No.:

11/108164

Inventors:

Sung Hwan Moon - Suwon-shi, KR
Jae Uk Chung - Suwon-shi, KR
Sung Chan Lee - Suwon-shi, KR
Masakatsu Eguchi - Bellevue WA, US
Michael Kahn - Kirkland WA, US
Kwang Won Jeong - Seoul, KR
Cu Nguyen - Arlington WA, US
Soo Jin Lee - Suwon-shi, KR

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

C07D 487/04
A61K 31/53
A61P 35/00

US Classification:

514243, 544184

Abstract:

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

US Patent:

7576084, Aug 18, 2009

Filed:

Apr 16, 2004

Appl. No.:

10/826972

Inventors:

Sung Hwan Moon - Kyunggi-do, KR
Jae Uk Chung - Kyunggi-do, KR
Sung Chan Lee - Kyunggi-do, KR
Masakatsu Eguchi - Bellevue WA, US
Michael Kahn - Kirkland WA, US
Kwang Won Jeong - Seoul, KR
Cu Nguyen - Arlington WA, US

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

C07D 487/04
A61K 31/53
A61P 35/00

US Classification:

514243, 544184

Abstract:

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

US Patent:

7585862, Sep 8, 2009

Filed:

Oct 4, 2005

Appl. No.:

11/242653

Inventors:

Sung Hwan Moon - Suwon-shi, KR
Jae Uk Chung - Suwon-shi, KR
Sung Chan Lee - Suwon-shi, KR
Masakatsu Eguchi - Bellevue WA, US
Michael Kahn - Kirkland WA, US
Kwang Won Jeong - Seoul, KR
Cu Nguyen - Arlington WA, US

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

C07D 487/04
A61K 31/53

US Classification:

514249, 544350

Abstract:

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

US Patent:

7671054, Mar 2, 2010

Filed:

Oct 15, 2007

Appl. No.:

11/974941

Inventors:

Sung Hwan Moon - Suwon-shi, KR
Jae Uk Chung - Suwon-shi, KR
Sung Chan Lee - Suwon-shi, KR
Masakatsu Eguchi - Bellevue WA, US
Michael Kahn - Kirkland WA, US
Kwang Won Jeong - Seoul, KR
Cu Nguyen - Pasadena CA, US
Soo Jin Lee - Suwon-shi, KR

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

C07D 487/04
A61K 31/53
A61P 19/02
A61P 35/00

US Classification:

514243, 544184

Abstract:

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins as well as their prodrugs are disclosed. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds and prodrugs for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

US Patent:

7932384, Apr 26, 2011

Filed:

Jul 27, 2009

Appl. No.:

12/510107

Inventors:

Sung Hwan Moon - Suwon-shi, KR
Jae Uk Chung - Suwon-shi, KR
Sung Chan Lee - Suwon-shi, KR
Masakatsu Eguchi - Bellevue WA, US
Michael Kahn - Los Angeles CA, US
Kwang Won Jeong - Seoul, KR
Cu Nguyen - Pasadena CA, US
Soo Jin Lee - Suwon-shi, KR

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

C07D 487/04
A61K 31/53
A61P 19/02
A61P 35/00

US Classification:

544184, 514243

Abstract:

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

US Patent:

8101751, Jan 24, 2012

Filed:

Aug 14, 2009

Appl. No.:

12/541388

Inventors:

Sung Hwan Moon - Suwon-shi, KR
Jae Uk Chung - Suwon-shi, KR
Sung Chan Lee - Suwon-shi, KR
Masakatsu Eguchi - Bellevue WA, US
Michael Kahn - Los Angeles CA, US
Kwang Won Jeong - Seoul, KR
Cu Nguyen - Pasadena CA, US

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

C07D 487/04
A61K 31/53
A61P 19/02
A61P 35/00

US Classification:

544184, 514243

Abstract:

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

US Patent:

8106049, Jan 31, 2012

Filed:

Sep 3, 2009

Appl. No.:

12/553858

Inventors:

Sung Hwan Moon - Suwon-shi, KR
Jae Uk Chung - Suwon-shi, KR
Sung Chan Lee - Suwon-shi, KR
Masakatsu Eguchi - Bellevue WA, US
Michael Kahn - Los Angeles CA, US
Kwang Won Jeong - Seoul, KR
Cu Nguyen - Pasadena CA, US

Assignee:

Choongwae Pharma Corporation - Seoul

International Classification:

C07D 487/04
A61K 31/53

US Classification:

514243, 544184

Abstract:

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility as diagnostic and therapeutic agents for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis. In one embodiment, these reverse-term mimetics have a general structure of formula (VI):.