Daniel Henry Reich

US Patent:

7132275, Nov 7, 2006

Filed:

May 14, 2002

Appl. No.:

10/143813

Inventors:

Daniel Reich - Baltimore MD, US
Gerald Meyer - Baltimore MD, US
Chia-Ling Chien - Lutherville MD, US
Christopher Chen - Baltimore MD, US
Peter C. Searson - Balto MD, US

Assignee:

The John Hopkins University - Baltimore MD

International Classification:

C07H 21/04
C12Q 1/68

US Classification:

4352871, 536 231, 536 243, 977704, 977728, 977769

Abstract:

The invention provides multisegmented, multifunctional magnetic nanowires for the probing and manipulation of molecules at the cellular and subcellular level. The different segments of the nanowire may have differing properties, including a variety of magnetic, non-magnetic, and luminescent behavior. Differences in surface chemistry allow different segments of a single nanowire to be functionalized with different multiple functional groups and/or ligands, giving the wire chemical multifunctionality.

US Patent:

20050079591, Apr 14, 2005

Filed:

Jul 6, 2004

Appl. No.:

10/885275

Inventors:

Daniel Reich - Baltimore MD, US
Monica Tanase - New York NY, US
Christopher Chen - Princeton MD, US

International Classification:

C12N013/00

US Classification:

435173100

Abstract:

In accordance with the invention, a surface is provided with a plurality of microscale magnets (“micromagnets”) disposed on a surface in a pattern to form a desired distribution of magnetic field strength. Cells and magnetic nanowires are attached, immersed in fluid, and flowed over the pattern. The nanowires and their bound cells are attracted to and bound to regions of the pattern as controlled by the geometry and magnetic properties of the pattern, the strength and direction of the fluid flow, and the strength and direction of an applied magnetic field.

US Patent:

20150302599, Oct 22, 2015

Filed:

Dec 5, 2012

Appl. No.:

14/362354

Inventors:

- Baltimore MD, US
- Rockville MD, US
Russell T. Shinohara - Baltimore MD, US
Arthur J. Goldsmith - Baltimore MD, US
Daniel Reich - Washington DC, US

International Classification:

G06T 7/00
G01T 1/16
G01R 33/48
A61B 8/00
A61B 5/00
A61B 5/055
A61B 6/03
G01R 33/50
G06F 19/00

Abstract:

A method of automatically detecting tissue abnormalities in images of a region of interest of a subject includes obtaining first image data for the region of interest of the subject, normalizing the first image data based on statistical parameters derived from at least a portion of the first image data to provide first normalized image data, obtaining second image data for the region of interest of the subject, normalizing the second image data based on statistical parameters derived from at least a portion of the second image data to provide second normalized image data, processing the first and second normalized image data to provide resultant image data, and generating a probability map for the region of interest based on the resultant image data and a predefined statistical model. The probability map indicates the probability of at least a portion of an abnormality being present at locations within the region of interest.