David F Aitcheson

US Patent:

49942131, Feb 19, 1991

Filed:

May 17, 1988

Appl. No.:

7/194838

Inventors:

David F. Aitcheson - San Jose CA
Renee A. Tenzel - Mountain View CA

Assignee:

Liposome Technology, Inc. - Menlo Park CA

International Classification:

A61K 9133
A61K 9127
B01J 1312

US Classification:

264 46

Abstract:

A method of forming lipid structures, such as liposomes is disclosed. Lipids are dissolved in a solvent system containing a water-miscible solvent, such as ethanol, and an aqueous medium. The water:solvent ratio is raised by removing water and solvent in a reverse osmosis system, and replacing lost solvent with added aqueous medium, preferably at a rate which just balances volume loss by reverse osmosis. In one embodiment, the method is used to produce uniform-size liposomes.

US Patent:

50008870, Mar 19, 1991

Filed:

May 17, 1988

Appl. No.:

7/194856

Inventors:

Renee A. Tenzel - Mountain View CA
David F. Aitcheson - San Jose CA

Assignee:

Liposome Technology, Inc. - Menlo Park CA

International Classification:

A61K 9133
A61K 9127
B01J 1312

US Classification:

264 46

Abstract:

A method of forming liposomes with a uniform size distribution, and an average size of about 300 nm or less. Vesicles-forming lipids are dissolved in a water-miscible solvent, such as ethanol, and an aqueous medium is added to a water:solvent ratio at which lipid assembly first occurs. The water:solvent ratio is raised, under conditions which maintain the volume of the mixture substantially constant, until uniform-size liposomes are formed. The average size of the liposomes can be selectively varied by changing the ionic strength and lipid composition of the mixture. In one embodiment, the method is used to produce small unilamellar vesicles. Also disclosed are suspensions of liposomes which have a narrow, substantially symmetrical size distribution in a selected size range.

Address:

5017 Birch Holw Ln, Fort Worth, TX 76132

VIN:

WBANW1C59AC168413

Make:

BMW

Model:

5 SERIES

Year:

2010