David T Chao

US Patent:

60156821, Jan 18, 2000

Filed:

Aug 31, 1995

Appl. No.:

8/521872

Inventors:

Richard A. Young - Weston MA
Anthony J. Koleske - Braintree MA
Craig M. Thompson - New Haven CT
David M. Chao - Cambridge MA

Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA

International Classification:

C12Q 148
C12N 912
C07K 100

US Classification:

435 15

Abstract:

Eukaryotic RNA polymerase II holoenzymes that contain RNA polymerase II and one or more regulatory SRB proteins are described. These holoenzymes will selectively initiate transcription in vitro when supplemented with general transcription factors such as TATA-binding protein (TBP) and factor a (TFIIE). The SRB proteins act positively and negatively to regulate transcription initiation, at least in part, via functional interactions with RNA polymerase II.

US Patent:

59288582, Jul 27, 1999

Filed:

Jul 18, 1997

Appl. No.:

8/897156

Inventors:

David M. Chao - Cambridge MA

International Classification:

C12Q 100
C12M 300

US Classification:

435 4

Abstract:

A removable marking sticker is provided for a Petri dish for correlating a cell on a Petri dish with a specific location. The sticker includes a backing substrate and a removable sticker element having an adhesive surface immediately adjacent to the backing substrate. The sticker has a plurality of dividing lines designated thereon in a predetermined configuration so as to define a plurality of locations.

US Patent:

58950230, Apr 20, 1999

Filed:

Mar 3, 1997

Appl. No.:

8/808026

Inventors:

David M. Chao - Cambridge MA

International Classification:

A47B 9704

US Classification:

248451

Abstract:

A document holder comprising two supporting members. Each supporting member includes an upper member which is aligned with an upper part of the document, a lower member which is aligned with a lower part of the document, and a resilient member which connects the upper portion to the lower portion and which exerts a bias force to make the upper portion substantially colinear with the lower portion. The newspaper is inserted between the two supporting members such that the horizontal crease of the document is aligned or overlaps with the resilient member. The resilient member allows the document to be folded up into a smaller size to facilitate reading, and exerts a bias force to open the document after a page has been read to facilitate page turning. The supporting members may include one or more mortise and tenon joints which allow the supporting members to be disengaged and folded for compact storage.

US Patent:

59196661, Jul 6, 1999

Filed:

Oct 11, 1995

Appl. No.:

8/540804

Inventors:

Richard A. Young - Weston MA
Anthony J. Koleske - Braintree MA
Craig M. Thompson - New Haven CT
David Min Chao - Cambridge MA

Assignee:

Whitehead Institute for Biomedical Research - Cambrige MA

International Classification:

C12P 1934
C12N 912
C07K 100

US Classification:

435 912

Abstract:

Eukaryotic RNA polymerase II holoenzymes that contain RNA polymerase II and one or more regulatory SRB proteins are described. These holoenzymes will selectively initiate transcription in vitro when supplemented with general transcription factors such as TATA-binding protein (TBP) and factor a (TFIIE). The SRB proteins act positively and negatively to regulate transcription initiation, at least in part, via functional interactions with RNA polymerase II.

US Patent:

57635935, Jun 9, 1998

Filed:

Jul 29, 1996

Appl. No.:

8/681812

Inventors:

Richard A. Young - Weston MA
Ellen L. Gadbois - Cambridge MA
David M. Chao - Cambridge MA

Assignee:

Whitehead Institute for Biomedical Research

International Classification:

C07H 2102
C07H 2104

US Classification:

536 2374

Abstract:

A eukaryotic, global negative regulator of class II transcription, DNA sequences encoding the negative regulator and results demonstrating the activity of the purified negative regulator protein to repress class II transcription are described.

US Patent:

62145886, Apr 10, 2001

Filed:

Jan 26, 1996

Appl. No.:

8/590399

Inventors:

Richard A. Young - Weston MA
Anthony J. Koleske - Braintree MA
Craig M. Thompson - New Haven CT
David M. Chao - Cambridge MA

Assignee:

Whitehead Institute Biomedical Research - Cambridge MA

International Classification:

C12P 1934
C12N 912
C07K 100
C07H 2102

US Classification:

435 913

Abstract:

Eukaryotic RNA polymerase II holoenzymes that contain RNA polymerase II and one or more regulatory proteins are described. These holoenzymes selectively initiate transcription in vitro when supplemented with general transcription factors. The regulatory proteins act positively and negatively to regulate transcription initiation, at least in part, via functional interactions with RNA polymerase II.