David Siu Ho

US Patent:

6510240, Jan 21, 2003

Filed:

May 9, 1995

Appl. No.:

08/437762

Inventors:

Sreenivasan Kalyani Koduri - Dallas TX
David Ho - Richardson TX
Yee Hsun U - Richardson TX

Assignee:

Texas Instruments Incorporated - Dallas TX

International Classification:

G06K 900

US Classification:

382146, 382151

Abstract:

An apparatus detects the presence or absence of a semiconductor device. The apparatus includes a wire bonding machine to form a connection with the semiconductor device, and a camera to form an image of a position of the semiconductor device. A processor controls the wire bonding machine and transforms the image to pixel data. Additionally, the processor converts the pixel data to discrimination data to indicate whether the semiconductor device is present. The processor controls the wire bonding machine in accordance with the presence or the absence of the semiconductor device.

US Patent:

7862744, Jan 4, 2011

Filed:

Jul 23, 2008

Appl. No.:

12/178527

Inventors:

David Losan Ho - Los Angeles CA, US
Zhenghao Wan - Wyuishan, CN

Assignee:

Mamtek International Limited - Hong Kong

International Classification:

C09K 3/00
C07H 17/02
C07H 1/00
C07H 1/06
B01D 11/00
B01D 21/01
B01D 37/00

US Classification:

25218212, 536 172, 536124, 536127, 210634, 210734, 210767, 210770

Abstract:

The present invention provides a method for preparing DMF for sucralose production, including, e. g. , isolating DMF from a composition comprising DMF, water, and methanol, using a single-tower rectification system. In various embodiments of the present invention, the composition, after the removal of water and methanol, may be further dried/dehydrated, such as, by using a dehydration agent and/or filtration. The resulting substantially pure DMF may comprise at least about 98-99% DMF. The present invention further provides a method of preparing a composition comprising anhydrous sucrose for sucralose production, which may comprise mixing regular sucrose with a water-containing DMF composition, and drying the resulting sucrose-DMF composition. Also provided is a single-tower separation system for isolating DMF from a composition comprising DMF, water, and methanol.

US Patent:

8258291, Sep 4, 2012

Filed:

Oct 25, 2006

Appl. No.:

11/552789

Inventors:

David Losan Ho - Los Angeles CA, US
Wan Zhenghao - Wyuishan, CN

Assignee:

Mamtek International Limited - Hong Kong

International Classification:

C07H 1/00
C07H 5/02

US Classification:

536124, 536122

Abstract:

In one embodiment of the invention a method to prepare sucralose-6 -acylate through chlorinating sucrose-6-acylate by BTC in the process of sucralose preparation is disclosed. In this embodiment a Vilsmeier reagent is firstly prepared below 0 C. by dissolving BTC in DMF or in component solvent, containing DMF, toluene, dichloroethane, chloroform and carbon tetrachloride. Consequently, sucrose-6-ester was chlorinated by Vilsmeier reagent. BTC can also be dissolved in one or several organic solvent such as toluene, dichloroethane, chloroform and carbon tetrachloride, and added to a DMF solution of sucrose-6-acylate for chlorination. Sucralose was prepared through de-esterifying the obtained sucralose 6-ester using sodium methoxide/methanol or sodium ethoxide/ethanol.

US Patent:

20040259641, Dec 23, 2004

Filed:

Apr 21, 2004

Appl. No.:

10/828903

Inventors:

David Ho - Huntington Beach CA, US

International Classification:

G06F017/00
G06F019/00

US Classification:

463/042000

Abstract:

An interactive Internet-based reality game where participants, via an interactive website, create a publicly viewable profile in a server database that may contain such information as a photo of the participant and an accompanying paragraph of self-written text. The object of the game of the present invention is to get as many people as possible to look at the participant's profile thereby increasing his number of points. Points represent a scoring system related to the amount of public exposure a participant has received. The more people who view a participant's profile, the more exposure that participant will have and the more points he or she will accumulate. The result of playing this game is that the participant's image and thoughts can become widely known to a great number of other people.

US Patent:

20080103295, May 1, 2008

Filed:

Oct 25, 2006

Appl. No.:

11/552813

Inventors:

David Losan Ho - Los Angeles CA, US
Wan Zhenghao - Wyuishan City, CN

International Classification:

C07H 15/00
C13K 13/00

US Classification:

536 184, 53612313

Abstract:

One embodiment of the present invention is a process of making sucrose-6-ester from sucrose by transesterification in the presence of a solid super acid catalyst such as SO—TiO/AlOor SO—TiO. The sucrose-6-acetate is then chlorinated to afford sucralose-6-acetate, using BTC or thionyl chloride. Sucralose-6-acetate is converted into TPSGA for the purpose of purification. TPSGA is de-esterified by sodium methoxide/methanol or sodium ethoxide/ethanol to give sucralose.

US Patent:

20100022765, Jan 28, 2010

Filed:

Jul 23, 2008

Appl. No.:

12/178510

Inventors:

David Losan Ho - Los Angeles CA, US
Zhenghao Wan - Wyuishan City, JP

International Classification:

C07H 3/04

US Classification:

53612313

Abstract:

The present invention provides a method for purifying sucralose-6-ester for use in making sucralose, wherein the method eliminates the need of an esterification process. In particular, ethyl acetate and ether are used to extract and purify sucralose-6-ester from a sucralose production intermediate composition comprising sucralose-6-ester.

US Patent:

20110175022, Jul 21, 2011

Filed:

Oct 21, 2010

Appl. No.:

12/909646

Inventors:

David Losan Ho - Los Angeles CA, US
Zhenghao Wan - Wyuishan City, CN

International Classification:

C09K 3/00
C07C 231/24
B01D 3/00

US Classification:

25218212, 564216, 202163

Abstract:

The present invention provides a method for preparing DMF for sucralose production, including, e.g., isolating DMF from a composition comprising DMF, water, and methanol, using a single-tower rectification system. In various embodiments of the present invention, the composition, after the removal of water and methanol, may be further dried/dehydrated, such as, by using a dehydration agent and/or filtration. The resulting substantially pure DMF may comprise at least about 98-99% DMF. The present invention further provides a method of preparing a composition comprising anhydrous sucrose for sucralose production, which may comprise mixing regular sucrose with a water-containing DMF composition, and drying the resulting sucrose-DMF composition. Also provided is a single-tower separation system for isolating DMF from a composition comprising DMF, water, and methanol.

US Patent:

20110268656, Nov 3, 2011

Filed:

Dec 2, 2010

Appl. No.:

12/959340

Inventors:

David Ho - Los Angeles CA, US
Tove Olafsen - Reseda CA, US
Arye Lipman - El Segundo CA, US

International Classification:

A61K 51/10
A61P 37/02
A61K 39/395
A61P 35/00
C07K 16/32
A61K 49/00

US Classification:

424 149, 5303873, 424 91, 4241331, 4241781

Abstract:

In one embodiment, a minibody monomer that binds PSMA is provided. The minibody monomer is encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA, an artificial hinge sequence, and a human IgG CH3 sequence. In another embodiment, a CysDB monomer that binds PSMA is provided. The CysDB monomer may be encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA and a cysteine tail. In other embodiments, methods for diagnosing or treating a cancer associated with PSMA expression in a subject are provided.