David T Ho

US Patent:

7026350, Apr 11, 2006

Filed:

May 3, 2004

Appl. No.:

10/837785

Inventors:

David K. Ho - North Potomac MD, US
Raya Mandler - Bethesda MD, US
Kaye B. Dillah Upadhyay - Gaithersburg MD, US
David J. Newman - Wayne PA, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C07D 225/04
A61K 47/48
A61P 35/00

US Classification:

514425, 540461

Abstract:

The present invention relates to water-soluble drugs, compositions containing same, and, in particular, a water-soluble analogue of geldanamycin. This invention also relates to a method of producing water-soluble analogues of water-insoluble drugs through derivatization and conjugation with a polar moiety via a thiol ether bond with a heterobifunctional linking molecule.

US Patent:

7811558, Oct 12, 2010

Filed:

Aug 12, 2005

Appl. No.:

11/202376

Inventors:

David Ho - Fairfax VA, US
Cindy S. Orser - McLean VA, US
Alan S. Rudolph - Potomac MD, US

Assignee:

Cellphire, Inc. - Rockville MD

International Classification:

A01N 65/00

US Classification:

424 9372

Abstract:

The present invention provides compositions comprising freeze-dried platelets, microparticles, or both for use as a hemostat, such as for treating bleeding or injuries associated with bleeding. It also provides methods of treating injuries or wounds, and methods of causing blood to clot. Likewise, it provides methods of promoting healing of wounds or of healing wounds.

US Patent:

8097403, Jan 17, 2012

Filed:

Dec 14, 2007

Appl. No.:

11/956830

Inventors:

David Ho - McLean VA, US
Heather Jones - Germantown MD, US

Assignee:

Cellphire, Inc. - Rockville MD

International Classification:

A01N 1/02
A01N 63/00
G01N 33/86

US Classification:

435 2, 424 9372, 436 69

Abstract:

The present invention provides freeze-dried platelets and compositions comprising freeze-dried platelets for use as a diagnostic and calibration reagent for blood coagulation function. The invention also provides methods of diagnosing or monitoring blood coagulation function, including diagnosing or monitoring blood coagulation diseases and disorders. Kits for performing the methods of the invention are also included.

US Patent:

8486617, Jul 16, 2013

Filed:

Aug 12, 2005

Appl. No.:

11/659708

Inventors:

David Ho - McLean VA, US
Cindy S. Orser - McLean VA, US
Alan S. Rudolph - Potomac MD, US
Keith Moskowitz - Germantown MD, US
Joshua Dee - Germantown MD, US

Assignee:

Cellphirc, Inc - Rockville MD

International Classification:

A01N 1/02
A01N 63/00

US Classification:

435 2, 424 9372

Abstract:

The present invention provides processes for preparing freeze-dried platelets, freeze-dried platelets made by those processes, platelets reconstituted from those freeze-dried platelets, methods of using the platelets for therapeutic, diagnostic, and research purposes, and kits comprising the freeze-dried platelets.

US Patent:

8628960, Jan 14, 2014

Filed:

Jan 6, 2011

Appl. No.:

12/985399

Inventors:

David H. Ho - McLean VA, US
Stephen P. Bruttig - Murdock NE, US

Assignee:

Hememics Biotechnologies, Inc. - Rockville MD

International Classification:

C12N 5/00
C12N 5/02
A01N 1/00
A01N 1/02

US Classification:

435374, 435 11, 435 2

Abstract:

The present invention provides compositions comprising desiccated biologics comprising a cell, protein, virus, nucleic acid, carbohydrate, or lipid, or any combination thereof, along with at least one membrane penetrable sugar, and at least one membrane impenetrable sugar, wherein the moisture content is from 5% to 95%, and to methods of preparing the same, and to methods of treating animals using the same.

US Patent:

20060035383, Feb 16, 2006

Filed:

Jun 15, 2005

Appl. No.:

11/152774

Inventors:

David Ho - Fairfax VA, US
Keith Moskowitz - Germantown MD, US
Cindy Orser - McLean VA, US
Alan Rudolph - Potomac MD, US

International Classification:

G01N 31/00
G01N 33/86

US Classification:

436069000, 436016000

Abstract:

The present invention provides compositions comprising freeze-dried platelets, microparticles, or both for use as a diagnostic for blood coagulation function. The invention also provides methods of diagnosing or monitoring blood coagulation function, including diagnosing or monitoring blood coagulation diseases and disorders. Kits for performing the methods of the invention are also provided.

US Patent:

20060051731, Mar 9, 2006

Filed:

Aug 5, 2005

Appl. No.:

11/197310

Inventors:

David Ho - Fairfax VA, US
Joshua Dee - Germantown MD, US
Cindy Orser - McLean VA, US
Alan Rudolph - Potomac MD, US

International Classification:

A01N 1/02

US Classification:

435002000

Abstract:

The present invention provides processes for preparing freeze-dried platelets, freeze-dried platelets made by those processes, platelets reconstituted from those freeze-dried platelets, and kits comprising those freeze-dried platelets. The freeze-dried platelets of the invention have similar characteristics to fresh platelets, have an exceptionally long shelf-life, and can be used for all standard procedures in which fresh platelets are used, including both in vitro diagnostic and research procedures and in vivo therapies.

US Patent:

20070127423, Jun 7, 2007

Filed:

Apr 27, 2006

Appl. No.:

11/412768

Inventors:

David Ho - Cupertino CA, US

International Classification:

H04Q 7/24

US Classification:

370338000, 455433000

Abstract:

The present invention discloses a method for providing a client-requested location dependent information for a designated location through a wireless communication system. The method includes a step of detecting a presence of a wireless network client at the designate location by the wireless communication system wherein the wireless communication system includes a data record of client profile to enable a determination if there is such a client-requested location dependent information for the designated location from the user whereby the client-requested location dependent information may be provided to the client at the designated location through the wireless communication system.