Robert Jordan - Radnor PA, US Diane D. Petrone - Radnor PA, US Mary Ryan - Radnor PA, US
International Classification:
A61K 39/395 C07K 16/18 A01K 67/027 G01N 33/53
US Classification:
4241391, 5303879, 800 8, 435 71, 435 792
Abstract:
The invention relates to antibody compositions and use of the composition to detect disease processes associated with elaboration of proteases. The reagents are directed to assessing an IgG breakdown product that is the result of such proteolytic cleavage. The invention further relates to the use of a therapeutic immunospecific for IgG breakdown products retaining antigen binding but having lost effector functions.
Immunoglobulin Cleavage Fragments And Disease Indicators And Compositions For Detecting And Binding Such
The invention relates to antibody compositions and use of the composition to detect disease processes associated with elaboration of proteases. The reagents are directed to assessing an IgG breakdown product that is the result of such proteolytic cleavage. The invention further relates to the use of a therapeutic immunospecific for IgG protease cleavage products to restore effector function to antibody compositions that are subject to protease cleavage.
Immunoglobulin Cleavage Fragments As Disease Indicators And Compositions For Detecting And Binding Such
Robert Jordan - Thorton PA, US David Knight - Berwyn PA, US Randall Brezski - Spring House PA, US Mary Ryan - Spring House PA, US Diane Petrone - Chesterbrook PA, US
Assignee:
Janssen Biotech, Inc. - Horsham PA
International Classification:
A61K 38/00 C07K 14/00
US Classification:
530300, 530327
Abstract:
The invention relates to antibody compositions and use of the composition to detect disease processes associated with elaboration of proteases. The reagents are directed to assessing an IgG breakdown product that is the result of such proteolytic cleavage. The invention further relates to the use of a therapeutic immunospecific for IgG protease cleavage products to restore effector function to antibody compositions that are subject to protease cleavage.
St. Mary's Academy-Visitation Providence RI 1973-1977
Community:
Elizabeth Beaumier, Rosalie Dibenedetto, Patty Madden, Karen Kazarian, Leslie Donfrancesco, Joan Smosna, Lori Broccoli, April Goddard, Kim Curria, Susan Audino, Susan Delvecchio