Kunyuan Cui - Bothell WA, US Dong Liang - Bothell WA, US David S. Sweedler - Louisville CO, US
Assignee:
NASTECH PHARMACEUTICAL COMPANY INC. - Bothell WA
International Classification:
A61K 48/00 C12N 15/88
US Classification:
514 44, 435458
Abstract:
A composition of an interfering RNA comprising a double-stranded RNA (dsRNA) molecule having a double-stranded region of from about 15 to about 40 base pairs, a peptide having a hydrophobic region and a cationic region, and a non-cationic phospholipid, and uses thereof.
Compositions And Methods For Delivery Of Double-Stranded Rna
Kunyuan Cui - Bothell WA, US Roger Adami - Snohomish WA, US Dong Liang - Everett WA, US
Assignee:
NASTECH PHARMACEUTICAL COMPANY INC. - Bothell WA
International Classification:
A61K 48/00 C12N 15/88
US Classification:
514044000, 435458000
Abstract:
Pharmaceutical compositions and methods of use of a composition containing a double-stranded RNA (dsRNA), cationic lipids, non-cationic lipids, and lipophilic delivery-enhancing compounds.
Long Interfering Nucleic Acid Duplexes Targeting Multiple Rna Targets
Dong Liang - Everett WA, US David Sweedler - Louisville CO, US Kunyuan Cui - Botthell WA, US
International Classification:
A61K 31/713 C12N 15/113
US Classification:
514 44 A, 536 245
Abstract:
Long interfering nucleic acid (iNA) duplexes, which are at least 30 nucleotides in length, which have at least one nick or nucleotide gap in the antisense or the sense strands or in both the sense and antisense strands. These long iNA duplexes do not induce an interferon response when transfected into mammalian cells. The antisense strands can target two separate mRNAs or two segments of one mRNA.
Compositions Comprising Cationic Amphiphiles And Colipids For Delivering Therapeutic Molecules
This disclosure provides compositions that are useful combined with therapeutics, and in the diagnosis and treatment of diseases and conditions. The compositions are useful for delivery of agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.
"I would jump on it when it opens for purchase in Canada", Dong Liang. "It is a bargain for that price at here. Most carriers lock us in for 3 years for huge monthly fee". Google initially only offers Galaxy Nexus direct in the United States, but indicates expansion to other countries.
Date: May 03, 2012
Category: Sci/Tech
Source: Google
China's Stocks, Bonds Slump on Banking Curbs; Rate Swaps Jump
The central banks move will cut lenders profits by an average of 1.36 percent, according to Shenyin & Wanguo Securities Co. Shenzhen Bank will be hurt most with net income reduced by 7.11 percent, analysts led by Dong Liang at the brokerage, wrote in a report today.
growth forecasts for this year cut to 25.9 percent last week from 28 percent at Shenyin & Wanguo Securities Co. Banks need to make an additional 48.8 billion yuan of provisions for lending to local government financing vehicles in 2011 and 2012, analysts led by Dong Liang wrote in a June 30 report.