Dong Jin Lim

US Patent:

20220387304, Dec 8, 2022

Filed:

Oct 2, 2020

Appl. No.:

17/765926

Inventors:

- Birmingham AL, US
Dong Jin LIM - Birmingham AL, US
Bradford A. WOODWORTH - Mountainbrook AL, US

International Classification:

A61K 9/00
A61K 31/496
A61K 31/7052
A61K 31/47
A61L 31/10
A61L 31/16

Abstract:

Disclosed herein are bilayered substrates useful for treating infection and/or inflammation in a subject such as, for example, the upper respiratory system. In another aspect, the layers of the substrates disclosed herein include biocompatible and biodegradable polymers as well as one or more bioactive agents useful for treating infection and/or inflammation. In a further aspect, the layers of the substrate can contain nanoparticles incorporating the bioactive agents. In any one of the above aspects, the bioactive agents are released at a constant rate over a period of time. In still another aspect, the substrates disclosed herein are useful for reducing the mass of biofilms and reducing or preventing inflammation by inhibiting the production of interleukin-8.

US Patent:

20150266225, Sep 24, 2015

Filed:

Mar 19, 2015

Appl. No.:

14/663316

Inventors:

Dong Jin Lim - Atlanta GA, US
Jeremy Benton Vines - Birmingham AL, US

Assignee:

CAS IN BIO CO., LID. - Seongnam-si

International Classification:

B29C 47/06
A61L 27/38
B32B 37/24
A61L 27/18
A61L 27/16
B29C 47/00
A61L 27/58
A61L 27/56

Abstract:

This invention describes a modified electrospinning method for making uniformly patterned and porous nanofibrous scaffolds that can be utilized in a variety of applications. While traditional electrospinning method uses a foil collector that generates compact layers of nanofibrous structures, resulting on the superficial cell growth and differentiation, the present method comprises adopting additional patterned film(s) on top of the conventional collector to make a patterned porous structure of nanofibrous scaffolds that are capable of supporting cell growth. For example, the method uses a double layered collector composed of a water soluble stabilizer film mounted on a foil to make a uniformly patterned and porous nanofibrous membrane sheets, which enhance both cell growth and attachment.