- Uniondale NY, US Satish Kumar Sakilam - Harrison NJ, US Satishkumar Gadhiya - Jamaica NY, US Dong Sung Lim - Fair Lawn NJ, US Yao Zong - Port Washington NY, US Shashikanth Ponnala - Secaucus NJ, US Ying Zhang - Glen Cove NY, US Dawoon Jung - Tenafly NJ, US Lambertus J.W.M. Oehlen - Westbury NY, US
The present invention provides compounds having formula (I): and pharmaceutically acceptable salts thereof, wherein Cy1, Cy2, Cy3, R, R, R, and Rare as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which inhibiting ROCK1, ROCK2, or ROCK1/2 has a therapeutically useful role.
Solid Forms Of (E)-3-[2-(2-Thienyl)Vinyl]-1H-Pyrazole
- Uniondale NY, US Dibyendu Dana - Elmont NY, US Dong Sung Lim - Fair Lawn NJ, US Satishkumar Gadhiya - Jamaica NY, US Dawoon Jung - Tenafly NJ, US Prakash Narayan - East Northport NY, US Quaisar Ali - Franklin Square NY, US Latha Paka - Elmont NY, US Itzhak D. Goldberg - Englewood NJ, US
International Classification:
C07D 403/14 C07D 401/14
Abstract:
The present invention provides compounds having formula (I): and pharmaceutically acceptable salts thereof, wherein Cy1, Cy2, Cy3, R, R, R, R, Aand Aare as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which inhibiting ROCK1, ROCK2, or ROCK1/2 has a therapeutically useful role.
- Uniondale NY, US Dong Sung Lim - Fair Lawn NJ, US Rama K. Mishra - Chicago IL, US Lambertus J.W.M. Oehlen - Westbury NY, US James G. Tarrant - Searcy AR, US Xiaokang Zhu - Oakland Gardens NY, US Dawoon Jung - Tenafly NJ, US
Assignee:
Angion Biomedica Corp - Uniondale NY
International Classification:
C07D 417/06
Abstract:
The present invention provides compounds having the general structural formula (I)and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.
Facile Methods For Fabricating A Uniformly Patterned And Porous Nanofibrous Scaffold
This invention describes a modified electrospinning method for making uniformly patterned and porous nanofibrous scaffolds that can be utilized in a variety of applications. While traditional electrospinning method uses a foil collector that generates compact layers of nanofibrous structures, resulting on the superficial cell growth and differentiation, the present method comprises adopting additional patterned film(s) on top of the conventional collector to make a patterned porous structure of nanofibrous scaffolds that are capable of supporting cell growth. For example, the method uses a double layered collector composed of a water soluble stabilizer film mounted on a foil to make a uniformly patterned and porous nanofibrous membrane sheets, which enhance both cell growth and attachment.