Donovan A Chin from 14435 48Th St, Phoenix, AZ 85044, age 52

Us Patents

Method And System For Planning, Performing, And Assessing High-Throughput Screening Of Multicomponent Chemical Compositions And Solid Forms Of Compounds
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US Patent:

20050118637, Jun 2, 2005
Filed:

Mar 22, 2002
Appl. No.:

10/103983
Inventors:

Douglas Levinson - Sherborn MA, US
Donovan Chin - Lexington MA, US
International Classification:

G01N033/53
G06F019/00
G01N033/48
G01N033/50
G01N033/543
US Classification:

435007100, 436518000, 702019000
Abstract:

The present application is directed to the use of computerized data processing to plan, perform, and assess the results of high-throughput screening of multicomponent chemical compositions and solid forms of compounds. Systems utilized include databases of molecular descriptors and related compounds and their properties as determined empirically and through simulation, along with multidimensional visualization tools. Methods include methods for determining chemical compositions by performing steps including selecting a plurality of combinations of values of experimental parameters that can be varied by an automated experiment apparatus, determining a set of experimental results, and determining a second plurality of combinations of values based on the set of experimental results. Additional methods include selecting values of parameters that produce a composition, the values being relatively far from areas of rapid change or boundaries between solid forms.

Computerized Control Of High-Throughput Experimental Processing And Digital Analysis Of Comparative Samples For A Compound Of Interest
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US Patent:

20070020662, Jan 25, 2007
Filed:

Aug 24, 2006
Appl. No.:

11/467061
Inventors:

Michael Cima - Winchester MA, US
Douglas Levinson - Sherborn MA, US
Donovan Chin - Lexington MA, US
Christopher McNulty - Arlington MA, US
Christopher Moore - Cambridge MA, US
Anthony Lemmo - Sudbury MA, US
Alasdair Johnson - Newburyport MA, US
Hongming Chen - Acton MA, US
Orn Almarsson - Shrewsbury MA, US
Assignee:

Transform Pharmaceuticals, Inc. - Lexington MA
International Classification:

C12Q 1/68
G01N 33/53
G06F 19/00
US Classification:

435006000, 435007100, 702019000, 702020000
Abstract:

The present invention relates to computer-controlled automated high-throughput systems and/or computer-program products to design, prepare, process, and analyze a large number of samples having experimental formulations each containing a compound of interest formulated with differing component combinations and varying concentrations and component identities. The computer-controlled methods of the present invention allow determination of the effects of additional or inactive components, such as excipients, carriers, enhancers, adhesives, additives, and the like, on the compound of interest, such as pharmaceuticals. The invention thus encompasses the computer systems, computer methods, and computer-program products for computer-controlled automated high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for an intended use or purpose.

Arylphenylamino-,Arylphenylamide-, And Arylphenylether-Sulfide Derivatives
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US Patent:

20070259863, Nov 8, 2007
Filed:

Apr 28, 2005
Appl. No.:

11/587732
Inventors:

Donovan Chin - Lexington MA, US
Thomas Durand-Reville - Cambridge MA, US
Francine Farouz - Mercer Island WA, US
Kerry Fowler - Seattle WA, US
Kevin Guckian - Marlborough MA, US
Irina Jaconbson - Sammamish WA, US
Ramesh Kasar - Bellevue WA, US
Russell Petter - Stow MA, US
Daniel Scott - Weston MA, US
C. Gregory Sowell - Mukilteo WA, US
Eugene Thorsett - Kirkland WA, US
Edward Yin-Shiang Lin - Chestnut Hill MA, US
Assignee:

ICOS Corporation - Bothell WA
Biogen Idec MA Inc. - Cambridge MA
International Classification:

C07D 307/54
US Classification:

514228800, 514255060, 544406000, 544063000
Abstract:

The present invention relates in part to compounds of formulas I and III: and pharmaceutically-acceptable salts and prodrugs thereof. These compounds can be useful for treating diseases such as inflammatory and immune diseases. The present invention also relates to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a subject.

Modulators Of Interleukin-1 Receptor-Associated Kinase
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US Patent:

20110021513, Jan 27, 2011
Filed:

Sep 7, 2007
Appl. No.:

12/440154
Inventors:

Thomas Durand-Reville - Cambridge MA, US
Charles Jewell - Sudbury MA, US
Charles Hammond - Burlington MA, US
Donovan Chin - Lexington MA, US
Assignee:

Biogen Idec Ma Inc. - Cambridge MA
International Classification:

A61K 31/538
A61K 31/5377
A61K 31/5025
C07D 487/04
A61P 29/00
A61P 37/00
A61P 19/02
A61P 19/10
A61P 9/10
A61P 25/28
A61P 17/06
A61P 25/16
A61P 3/10
A61P 31/04
US Classification:

5142305, 5142332, 514248, 544105, 544117, 544236
Abstract:

The present invention relates to modulators of IRAK kinase and provides compositions comprising such modulators, as well as methods therewith for treating conditions or diseases mediated by or associated with IRAK kinase.

1,4-Disubstituted Pyridazine Analogs There Of And Methods For Treating Smn-Deficiency-Related Conditions
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US Patent:

20140051672, Feb 20, 2014
Filed:

Aug 7, 2013
Appl. No.:

13/960917
Inventors:

Atwood Kim CHEUNG - Arlington MA, US
Donovan Noel CHIN - Lexington MA, US
Natalie DALES - Arlington MA, US
Aleem FAZAL - Burlington MA, US
Timothy Brian HURLEY - Boston MA, US
John KERRIGAN - Wakefield MA, US
Gary O'BRIEN - Maynard MA, US
Lei SHU - Woburn MA, US
Robert SUN - Natick MA, US
Moo Je SUNG - Belmont MA, US
International Classification:

C07D 401/12
A61K 45/06
C07D 409/14
C07D 401/14
A61K 31/502
C07D 413/14
C07D 417/14
A61K 31/5377
C07D 403/12
A61K 31/551
C07D 471/08
C07D 471/10
C07D 471/04
C07D 403/14
C07D 403/10
C07D 487/10
C07D 487/04
C07D 237/20
C07D 401/04
C07D 405/14
A61K 31/506
A61K 31/501
US Classification:

5142102, 544238, 51425203, 51425204, 514249, 514248, 544237, 544114, 5142365, 51425205, 51425202, 514218, 540575, 544230, 51425206
Abstract:

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

1,4-Disubstituted Pyridazine Analogs There Of And Methods For Treating Smn-Deficiency-Related Conditions
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US Patent:

20220387428, Dec 8, 2022
Filed:

Dec 13, 2021
Appl. No.:

17/644045
Inventors:

- Basel, CH
Donovan Noel CHIN - Lexington MA, US
Natalie DALES - Arlington MA, US
Aleem FAZAL - Wilmington MA, US
Timothy Brian HURLEY - Boston MA, US
John KERRIGAN - Wakefield MA, US
Gary O'BRIEN - Maynard MA, US
Lei SHU - Lexington MA, US
Robert SUN - Natick MA, US
Moo Je SUNG - Belmont MA, US
International Classification:

A61K 31/501
A61P 21/00
A61K 31/502
A61K 31/506
A61K 31/5377
A61K 31/551
A61K 45/06
C07D 237/20
C07D 401/04
C07D 401/12
C07D 401/14
C07D 403/10
C07D 403/12
C07D 403/14
C07D 405/14
C07D 409/14
C07D 413/14
C07D 417/14
C07D 471/04
C07D 471/08
C07D 471/10
C07D 487/04
C07D 487/10
A61K 31/41
A61K 31/427
C07D 237/06
Abstract:

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

1,4-Disubstituted Pyridazine Analogs There Of And Methods For Treating Smn-Deficiency-Related Conditions
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US Patent:

20200345732, Nov 5, 2020
Filed:

Jul 21, 2020
Appl. No.:

16/934787
Inventors:

- Basel, CH
Donovan Noel CHIN - Lexington MA, US
Natalie DALES - Arlington MA, US
Aleem FAZAL - Burlington MA, US
Timothy Brian HURLEY - Boston MA, US
John KERRIGAN - Wakefield MA, US
Gary O'BRIEN - Maynard MA, US
Lei SHU - Lexington MA, US
Robert SUN - Natick MA, US
Moo Je SUNG - Belmont MA, US
International Classification:

A61K 31/501
A61K 31/502
A61K 31/506
A61K 31/5377
A61K 31/551
A61K 45/06
C07D 237/20
C07D 401/04
C07D 401/12
C07D 401/14
C07D 403/10
C07D 403/12
C07D 403/14
C07D 405/14
C07D 409/14
C07D 413/14
C07D 417/14
C07D 471/04
C07D 471/08
C07D 471/10
C07D 487/04
C07D 487/10
A61K 31/41
A61K 31/427
C07D 237/06
Abstract:

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

1,4-Disubstituted Pyridazine Analogs There Of And Methods For Treating Smn-Deficiency-Related Conditions
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US Patent:

20190358226, Nov 28, 2019
Filed:

Jan 2, 2019
Appl. No.:

16/237907
Inventors:

- Basel, CH
Donovan Noel CHIN - Lexington MA, US
Natalie DALES - Arlington MA, US
Aleem FAZAL - Burlington MA, US
Timothy Brian HURLEY - Boston MA, US
John KERRIGAN - Wakefield MA, US
Gary O'BRIEN - Maynard MA, US
Lei SHU - Woburn MA, US
Robert SUN - Natick MA, US
Moo Je SUNG - Belmont MA, US
International Classification:

A61K 31/501
A61K 31/427
C07D 487/10
A61K 31/502
A61K 31/506
A61K 31/5377
A61K 31/551
C07D 237/06
C07D 487/04
A61K 45/06
C07D 237/20
C07D 401/04
C07D 401/12
C07D 401/14
C07D 403/10
C07D 403/12
C07D 403/14
C07D 405/14
C07D 409/14
C07D 413/14
C07D 417/14
C07D 471/04
C07D 471/08
C07D 471/10
A61K 31/41
Abstract:

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.