Doris A Schumacher

US Patent:

6875866, Apr 5, 2005

Filed:

Feb 19, 2003

Appl. No.:

10/368973

Inventors:

Vilas H. Dahanukar - Edison NJ, US
Jeffrey M. Eckert - Hazlet NJ, US
Dinesh Gala - East Brunswick NJ, US
Brian Lucas - Madison WI, US
Doris P. Schumacher - Bedminster NJ, US
Ilia Zavialov - East Windsor NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D223/14

US Classification:

540576

Abstract:

In one embodiment, the present invention describes the synthesis of a compound of formula and intermediates therefor.

US Patent:

7071342, Jul 4, 2006

Filed:

Apr 16, 2004

Appl. No.:

10/826456

Inventors:

Jianguo Yin - Edison NJ, US
Xiaoyong Fu - Edison NJ, US
Shuyi Zhang - Parsippany NJ, US
Timothy L. McAllister - Westfield NJ, US
Jason L. Winters - East Windsor NJ, US
Anantha Sudhakar - East Brunswick NJ, US
Doris P. Schumacher - Bedminster NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 307/54

US Classification:

549494

Abstract:

Disclosed is a process for making the compound of formula I:.

US Patent:

7462740, Dec 9, 2008

Filed:

May 9, 2006

Appl. No.:

11/430687

Inventors:

Jianguo Yin - Edison NJ, US
Xiaoyong Fu - Edison NJ, US
Shuyi Zhang - Parsipanny NJ, US
Timothy L. McAllister - Westfield NJ, US
Jason L. Winters - East Windsor NJ, US
Anantha Sudhakar - East Brunswick NJ, US
Doris P. Schumacher - Bedminster NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07C 231/02
C07C 233/65

US Classification:

564139, 564167

Abstract:

Disclosed is a process for making the compound of formula I:.

US Patent:

7910775, Mar 22, 2011

Filed:

Oct 17, 2008

Appl. No.:

12/253356

Inventors:

Jianguo Yin - Edison NJ, US
Xiaoyong Fu - Edison NJ, US
Shuyi Zhang - Parsipanny NJ, US
Timothy L. McAllister - Westfield NJ, US
Jason L. Winters - East Windsor NJ, US
Anantha Sudhakar - East Brunswick NJ, US
Doris P. Schumacher - Bedminster NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07C 231/02
C07C 233/05

US Classification:

564167, 564142, 564166

Abstract:

Disclosed is a process for making the compound of formula I:.

US Patent:

47314478, Mar 15, 1988

Filed:

Mar 12, 1986

Appl. No.:

6/839016

Inventors:

Doris P. Schumacher - Florham Park NJ
Bruce L. Murphy - Elizabeth NJ
Jon E. Clark - Highland Park NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D22116

US Classification:

546 93

Abstract:

A process for the preparation of piperidylidene-dihydro-dibenzo[a,d]cycloheptene or aza-derivatives thereof and intermediates in such process are disclosed.

US Patent:

48639311, Sep 5, 1989

Filed:

Sep 15, 1988

Appl. No.:

7/244768

Inventors:

Doris P. Schumacher - Florham Park NJ
Bruce L. Murphy - Glen Ridge NJ
Jon E. Clark - Highland Park NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31445
C07D40104

US Classification:

514290

Abstract:

Certain benzocycloheptapyridine compounds with fluorine substitution across the exocyclic double bond are prepared and they are useful as antihistaminic agents.

US Patent:

53826736, Jan 17, 1995

Filed:

Apr 22, 1993

Appl. No.:

8/039450

Inventors:

Jon E. Clark - Highland Park NJ
Doris P. Schumacher - Florham Park NJ
Guang-Zhong Wu - Somerville NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D26308

US Classification:

548239

Abstract:

A process for preparing a compound of formula (IV): ##STR1## comprising a) contacting an oxazoline compound of formula (I): ##STR2## wherein Z is as defined hereinbefore, with a reagent capable of causing an equilibrium between oxazoline compound (I) and an oxazoline compound of formula (II) described herein, and the reagent drives the equilibrium toward oxazoline compound (II) by preferential precipitation of oxazoline compound (II); b) contacting compound (II) with a fluorinating agent to give a fluorinated oxazoline compound of formula (III) described herein; and c) hydrolyzing the compound of formula (III) to formula (IV). In an alternative embodiment, the process is directed toward a process for preparing oxazoline (II) in a single step.

US Patent:

43663095, Dec 28, 1982

Filed:

Apr 13, 1981

Appl. No.:

6/253138

Inventors:

Ashit K. Ganguly - Upper Montclair NJ
Yi-Tsung Liu - Parsippany NJ
Olga Sarre - Verona NJ
Robert Jaret - Livingston NJ
Doris P. Schumacher - Florham Park NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07H 1708

US Classification:

536 71

Abstract:

Novel macrolide antibacterial derivatives of the components of the Antibiotic AR-5-complex are disclosed herein. The invention specifically relates to compounds wherein the macrolide ring and/or the two attached sugars are derivatized. Also disclosed are methods for the preparation of the derivatives and methods for the use thereof.